Liquid delivery compositions
First Claim
1. A delivery composition suitable for in situ formation of a solid implant for controlled release of an active agent, the composition comprising:
- (a) a biocompatible organic solvent which has a solubility range of miscible to dispersible in aqueous medium;
(b) a biocompatible, biodegradable, thermoplastic polymer dissolved in the organic solvent, the thermoplastic polymer being insoluble in aqueous medium; and
(c) an active agent incorporated into a particulate controlled release component, the particulate controlled release component being suspended in the organic solvent wherein upon contacting an aqueous medium, the organic solvent dissipates ordisperses into the aqueous medium and the thermoplastic polymer precipitates or coagulates to form the solid implant in which the particulate controlled release component is embedded.
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Accused Products
Abstract
Improved biocompatible liquid delivery compositions, which are useful for the formation of sustained release delivery systems for active agents, are provided. The compositions include liquid formulations of a biocompatible polymer or prepolymer in combination with a controlled release component. The controlled release component includes an active agent. These compositions may be introduced into the body of a subject in liquid form which then solidify or cure in situ to form a controlled release implant or a film dressing. The liquid delivery compositions may also be employed ex situ to produce a controlled release implant. Methods of forming a controlled release implant and employing the liquid formulations in the treatment of a subject are also provided.
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Citations
15 Claims
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1. A delivery composition suitable for in situ formation of a solid implant for controlled release of an active agent, the composition comprising:
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(a) a biocompatible organic solvent which has a solubility range of miscible to dispersible in aqueous medium; (b) a biocompatible, biodegradable, thermoplastic polymer dissolved in the organic solvent, the thermoplastic polymer being insoluble in aqueous medium; and (c) an active agent incorporated into a particulate controlled release component, the particulate controlled release component being suspended in the organic solvent wherein upon contacting an aqueous medium, the organic solvent dissipates or disperses into the aqueous medium and the thermoplastic polymer precipitates or coagulates to form the solid implant in which the particulate controlled release component is embedded. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification