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Liquid delivery compositions

  • US 5,780,044 A
  • Filed: 12/05/1996
  • Issued: 07/14/1998
  • Est. Priority Date: 04/08/1994
  • Status: Expired due to Term
First Claim
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1. A delivery composition suitable for in situ formation of a solid implant for controlled release of an active agent, the composition comprising:

  • (a) a biocompatible organic solvent which has a solubility range of miscible to dispersible in aqueous medium;

    (b) a biocompatible, biodegradable, thermoplastic polymer dissolved in the organic solvent, the thermoplastic polymer being insoluble in aqueous medium; and

    (c) an active agent incorporated into a particulate controlled release component, the particulate controlled release component being suspended in the organic solvent wherein upon contacting an aqueous medium, the organic solvent dissipates ordisperses into the aqueous medium and the thermoplastic polymer precipitates or coagulates to form the solid implant in which the particulate controlled release component is embedded.

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