Water soluble rapamycin esters
First Claim
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1. A compound of the structure ##STR4## wherein R1 and R2 are each, independently, hydrogen or --COCH2 --S--CH2 CH2 --O--CH2 --(CH2 OCH2)n --CH2 --O--CH2 CH2 --OCH3 ;
- and n=8-450;
with the proviso that R1 and R2 are not both hydrogen.
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Abstract
A compound of the structure ##STR1## wherein R1 and R2 are each, independently, hydrogen or
COCH2 --S--CH2 CH2 --O--CH2 --(CH2 OCH2)n --CH2 --O--CH2 CH2 --OCH3 ; and n=8-450; with the proviso that R1 and R2 are not both hydrogen, which is useful as an immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agent.
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9 Claims
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1. A compound of the structure ##STR4## wherein R1 and R2 are each, independently, hydrogen or --COCH2 --S--CH2 CH2 --O--CH2 --(CH2 OCH2)n --CH2 --O--CH2 CH2 --OCH3 ;
- and n=8-450;
with the proviso that R1 and R2 are not both hydrogen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
- and n=8-450;
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9. A pharmaceutical composition which comprises a compound of the structure ##STR5## wherein R1 and R2 are each, independently, hydrogen or --COCH2 --S--CH2 CH2 --O--CH2 --(CH2 OCH2)n --CH2 --O--CH2 CH2 --OCH3 ;
- and n=8-450;
with the proviso that R1 and R2 are not both hydrogen, and a pharmaceutical carrier.
- and n=8-450;
Specification