Electromagnetic bone-assessment apparatus and method

• US 5,782,763 A
• Filed: 07/01/1997
• Issued: 07/21/1998
• Est. Priority Date: 06/01/1995
• Status: Expired due to Fees

• Current Assignee: CyberLogic, Inc.
• Original Assignee: CyberLogic, Inc.
• Inventors: Kaufman, Jonathan J., Bianco, Bruno, Chiabrera, Alessandro
• Primary Examiner(s): Lateef, Marvin M
• Assistant Examiner(s): SHAW, SHAWNA JEANNINE
• Application Number:
  US08/886,323
• Time in Patent Office: 385 Days
• Field of Search: 600/407, 600/408, 600/547, 600/13, 324/228
• US Class Current: 600/407
• CPC Class Codes: A61B 5/053 Measuring electrical impedance or conductance of a portion of the body
• CPC Class Codes: A61B 5/417 the bone marrow
• CPC Class Codes: A61B 5/4504 Bones A61B5/4547 takes precedence
• CPC Class Codes: A61B 5/4509 Bone density determination
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: A61B 5/7264 Classification of physiological signals or data, e.g. using neural networks, statistical classifiers, expert systems or fuzzy systems neural networks per se G06N3/00; expert systems per se G06N5/00

Abstract

Non-invasive quantitative in-vivo electromagnetic evaluation of bone is performed by subjecting bone to an electrical excitation wave-form supplied to a pair of electrodes on opposite sides of a bony member, and involving a repetitive finite duration signal consisting of plural frequencies that are in the range 0 Hz-200 MHz. Signal-processing of a bone-current response signal and a bone-voltage response signal is operative to sequentially average the most recently received given number of successive bone-current and bone-voltage response signals to obtain an averaged per-pulse bone-current signal and an averaged per-pulse bone-voltage signal, and to produce their associated Fourier transforms. These Fourier transforms are further processed to obtain the frequency-dependent bone-admittance function. In a separate operation, the same electrodes respond to the same excitation signal via a medium of known electromagnetic properties and path length to establish a reference-voltage signal and reference-current signal, which are processed to produce their associated Fourier transforms. These two Fourier transforms are further processed to produce a frequency-dependent reference-admittance function, which together with the bone-admittance function are processed to derive the frequency-dependent bone-conductivity real function, σ'"'"'_b (f), and frequency-dependent dielectric bone-permittivity real function, .di-elect cons.'"'"'_b (f). The function σ'"'"'_b (f) is related to the energy loss in the bony member, and the function .di-elect cons.'"'"'_b (f) is related to the energy storage in the bony member. A neural network, configured to generate an estimate of one or more of the desired bone-related quantities, is connected for response to the functions σ'"'"'_b (f) and .di-elect cons.'"'"'_b (f), whereby to generate the indicated estimates of bone status, namely, bone-density, bone-architecture, bone-strength and bone-fracture risk.

Claims

1. Apparatus for non-invasive quantitative evaluation of the status of bone tissue in vivo, as measured in a selected bony member of a living body and manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk at a given time, said apparatus comprising;

circuit means including a pair of spaced magnetic field coils wherein the spacing is adapted to receive the bony member to be analyzed and wherein said circuit means is a two-port electrical circuit,

network analyzer means included in said circuit means for obtaining a set of three (3) inductively-determined two-port frequency-dependent bone-admittance functions when said circuit means includes said bony member;

means for selectively using said pair of magnetic field coils and said network analyzer with a medium of known electrical and magnetic properties and path length to thereby establish a set of three (3) inductively-determined two-port frequency-dependent reference-admittance functions, and including means to store each of said reference-admittance functions, and

means for comparatively evaluating said bone-admittance functions and reference-admittance functions, whereby to estimate one or more of the said quantities.

11. Apparatus according to any one of claims 1, 2, 5 and 6, wherein said means for comparative evaluation is adapted for further comparative evaluation of inputs selected from the group comprising:

age, sex, weight, height, bone-tissue thickness, soft-tissue thickness, overall tissue thickness, mental status, ultrasonic velocity measurements, ultrasonic attenuation measurements, and bone-densitometric measurements.

2. Apparatus for non-invasive quantitative evaluation of the status of bone tissue in vivo, as measured in a selected bony member of a living body and manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk at a given time, said apparatus comprising;

circuit means including a pair of spaced magnetic field coils wherein the spacing is adapted to receive the bony member to be analyzed and wherein said circuit means is a two-port electrical circuit,

network analyzer means included in said circuit means for obtaining a set of three (3) inductively-determined two-port frequency-dependent bone-admittance functions when said circuit means includes said bony member, and

means for comparatively evaluating said bone-admittance functions, whereby to estimate one or more of the said quantities.

3. Apparatus for non-invasive quantitative evaluation of the status of bone tissue in vivo, as measured in a selected bony member of a living body and manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk at a given time, said apparatus comprising;

circuit means including a pair of spaced magnetic field coils wherein the spacing is adapted to receive the bony member to be analyzed and wherein said circuit means is a two-port electrical circuit,

network analyzer means included in said circuit means for obtaining a set of three (3) inductively-determined two-port frequency-dependent bone-admittance functions when said circuit means includes said bony member;

means for selectively using said pair of magnetic field coils and said network analyzer with a medium of known electrical and magnetic properties and path length to thereby establish a set of three (3) inductively-determined two-port frequency-dependent reference-admittance functions, and including means to store each of said reference-admittance functions, and

means including a neural network connected for response to said bone-admittance functions and reference-admittance functions, said neural network being configured to generate an estimate of one or more of the said quantities.

7. Apparatus according to claim 3, wherein each of said frequency-dependent functions, namely the inductively-determined two-port frequency-dependent bone-admittance functions and the inductively-determined two-port frequency-dependent reference-admittance functions, are processed in polynomial form involving a finite set of coefficients for each polynomial, and means for supplying polynomials'"'"' coefficients as inputs to said neural network.

9. Apparatus according to any one of claims 3 and 4, wherein said neural network is adapted to receive further inputs selected from the group comprising:

age, sex, weight, height, bone-tissue thickness, soft-tissue thickness, overall tissue thickness, mental status, ultrasonic velocity measurements, ultrasonic attenuation measurements, and bone-densitometric measurements.

10. Apparatus according to any one of claims 3, and 4, wherein said neural network is replaced by a multivariate least-squares regression function.

4. Apparatus for non-invasive quantitative evaluation of the status of bone tissue in vivo, as measured in a selected bony member of a living body and manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk at a given time, said apparatus comprising;

circuit means including a pair of spaced magnetic field coils wherein the spacing is adapted to receive the bony member to be analyzed and wherein said circuit means is a two-port electrical circuit,

network analyzer means included in said circuit means for obtaining a set of four (4) inductively-determined two-port frequency-dependent bone-admittance functions when said circuit means includes said bony member, and

means including a neural network connected for response to said bone-admittance functions, said neural network being configured to generate an estimate of one or more of the said quantities.

8. Apparatus according to claim 4, wherein said frequency-dependent functions, namely the inductively-determined two-port frequency-dependent bone-admittance functions, are processed in polynomial form involving a finite set of coefficients for each of said polynomials, and means for supplying polynomials'"'"' coefficients as inputs to said neural network.

5. Apparatus for non-invasive quantitative evaluation of the status of bone tissue in vivo, as measured in a selected bony member of a living body and manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk at a given time, said apparatus comprising;

circuit means including a pair of spaced magnetic field coils wherein the spacing is adapted to receive the bony member to be analyzed and wherein said circuit means is a two-port electrical circuit,

network analyzer means included in said circuit means for obtaining a set of three (3) inductively-determined two-port frequency-dependent bone-admittance functions when said circuit means includes said bony member;

means for selectively using said pair of magnetic field coils and said network analyzer with a medium of known electrical and magnetic properties and path length to thereby establish a set of three (3) inductively-determined two-port frequency-dependent reference-admittance functions, and including means to store each of said reference-admittance functions;

additional circuit means including a pair of spaced electrodes wherein the spacing is adapted to receive the bony member to be analyzed and wherein said additional circuit means is a two-terminal electrical circuit,

impedance analyzer means included in said additional circuit means for obtaining a capacitively-determined frequency-dependent bone-admittance function when said additional circuit means includes said bony member;

means for selectively using said pair of electrodes and said impedance analyzer with an additional medium of known electrical and magnetic properties and path length to thereby establish a capacitively-determined frequency-dependent reference-admittance function, and including means to store said reference-admittance function, and

means for comparatively evaluating said capacitively-determined bone-admittance function and stored reference-admittance function, and said inductively-determined bone-admittance function and stored reference-admittance function whereby to estimate one or more of the said quantities.

6. Apparatus for non-invasive quantitative evaluation of the status of bone tissue in vivo, as measured in a selected bony member of a living body and manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk at a given time, said apparatus comprising;

circuit means including a pair of spaced magnetic field coils wherein the spacing is adapted to receive the bony member to be analyzed and wherein said circuit means is a two-port electrical circuit,

network analyzer means included in said circuit means for obtaining a set of three (3) inductively-determined two-port frequency-dependent bone-admittance functions when said circuit means includes said bony member;

additional circuit means including a pair of spaced electrodes wherein the spacing is adapted to receive the bony member to be analyzed and wherein said additional circuit means is a two-terminal electrical circuit,

impedance analyzer means included in said additional circuit means for obtaining a capacitively-determined frequency-dependent bone-admittance function when said additional circuit means includes said bony member, and

means for comparatively evaluating said capacitivly-determined bone-admittance function and said inductively-determined bone-admittance function whereby to estimate one or more of the said quantities.

12. The method of non-invasively and quantitatively evaluating the status of bone tissue in vivo, as manifested through one or more of the quantities:

bone-mineral density, architecture, strength and fracture risk, using two magnetic field coils that are spaced to receive a bony part of a living body, which method comprises the steps of;

(a) electrically coupling said magnetic field coils to nearby skin on opposite sides of said bony part, and whereby said magnetic field coils and bony part comprise a two-port electrical network;

(b) connecting a network analyzer to the said two-port electrical network, whereby to obtain a set of three (3) inductively-determined two-port frequency-dependent bone-admittance functions associated with said two-port electrical network; and

(c) comparatively evaluating the set of three (3) two-port bone-admittance functions.