Hyperspectral imaging methods and apparatus for non-invasive diagnosis of tissue for cancer
First Claim
Patent Images
1. An apparatus for diagnosis of tissue, the apparatus being optically coupled to the tissue being diagnosed, comprising:
- a) a light source;
b) an imaging optic;
c) a dispersion optic;
d) a detector;
e) a comparator; and
f) an indicator,said light source operable for converting electric energy to photon energy, the photon energy being coupled to tissue being diagnosed;
said imaging optic being disposed between the tissue and said detector in a manner which satisfies the imaging condition thereby forming an image on said detector;
said dispersion optic disposed between the tissue and said detector for dispersing light into a hyperspectral image;
said comparator being in electronic communication with said detector operable for receiving a signal from said detector and comparing it to a reference signal; and
said indicator being in communication with and responsive to said comparator operable for indicating coincidence and lack of coincidence between the reference and signal from said detector.
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Abstract
Techniques and devices for diagnosing tissue via hyperspectral imaging are presented. A three dimensional "image" where one dimension contains spectral information is formed from a region of interest. The spectral content of the image can be analyzed on a pixel-by-pixel basis to determine the presence of certain matter and the spatial extend thereof The techniques are non-invasive and do not require introduction of agents typically required to facilitate interaction with illumination sources.
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Citations
5 Claims
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1. An apparatus for diagnosis of tissue, the apparatus being optically coupled to the tissue being diagnosed, comprising:
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a) a light source; b) an imaging optic; c) a dispersion optic; d) a detector; e) a comparator; and f) an indicator, said light source operable for converting electric energy to photon energy, the photon energy being coupled to tissue being diagnosed; said imaging optic being disposed between the tissue and said detector in a manner which satisfies the imaging condition thereby forming an image on said detector; said dispersion optic disposed between the tissue and said detector for dispersing light into a hyperspectral image; said comparator being in electronic communication with said detector operable for receiving a signal from said detector and comparing it to a reference signal; and said indicator being in communication with and responsive to said comparator operable for indicating coincidence and lack of coincidence between the reference and signal from said detector. - View Dependent Claims (2)
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3. A method for diagnosis of tissue comprising the steps:
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a) illuminating a tissue sample; b) forming a hyperspectrally resolved image of the tissue sample; c) comparing the hyperspectrally resolved image with a reference; and d) indicating regions of coincidence and regions of non-coincidence with respect to the hyperspectrally resolved image and the reference, said hyperspectrally resolved image being comprised of a plurality of spectral bands, each spectral band being adjacent to another forming a continuous set, each spectral band having a bandwidth less than about 10 nanometers. - View Dependent Claims (4, 5)
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Specification