Method for automatic dosing of drugs

• US 5,782,799 A
• Filed: 02/07/1997
• Issued: 07/21/1998
• Est. Priority Date: 02/07/1997
• Status: Expired due to Term

• Current Assignee: Sterling Investments LC
• Original Assignee: Sarcos Incorporated (Rtx Corporation)
• Inventors: Jacobsen, Stephen C., Zentner, Gaylen M.
• Primary Examiner(s): YASKO JR, JOHN D
• Application Number:
  US08/797,296
• Time in Patent Office: 529 Days
• Field of Search: 604/49, 604/65-67, 604/20-23, 604/890.1, 604/891.1, 604/19, 604/131, 604/140, 604/93
• US Class Current: 604/500
• CPC Class Codes: A61D 7/00 Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals for reproduction or fertilisation A61D19/00 ; devices for implanting pellets, radon seeds or the like A61M37/0069
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

The method for automatic dosing of drugs utilizes a microdelivery device which may be implanted in or otherwise administered to an animal or human. A microdelivery device is configured to have a plurality of compartments, each containing at least one drug so that a plurality of doses of the drug(s) are held within the device. In accordance with the present invention, the microdelivery device selectively actuates the compartments to selectively release doses of the drug(s) to provide an efficacious dosing pattern. One primary function of the present invention is to release two or more pesticides in such a pattern that parasites are effectively controlled while preventing the development of tolerance to the drugs within the parasites. Preferably, the microdelivery device is programmable to effectuate the release of the drug(s) at a desired time to maintain efficacious levels of the drug while minimizing the amount of drug which must be used.

Claims

1. A method for automatic delivery of one or more drugs, the method comprising:

a) selecting a microdelivery system having a plurality of compartments disposed therein for holding a plurality of doses of at least a first drug to be administered to an animal/human;

b) administering the microdelivery system to the animal/human;

c) actuating the microdelivery system to provide an initial dose of the first drug from at least one compartment of the microdelivery system to the animal/human in sufficient quantity to exceed the efficacy threshold for the first drug in the animal/human; and

d) actuating the microdelivery system to provide a second dose of the first drug from at least one compartment of the microdelivery system to the animal/human at a predetermined time after the initial dose of the first drug and while the drug supplied by the initial dose remains above the efficacy threshold.

2. The method of claim 1, wherein step (a) comprises, more specifically, selecting a microdelivery system having a second drug disposed in at least one of the plurality of compartments, and wherein the method further comprises;

(e) actuating the microdelivery system to provide an initial dose of the second drug at a predetermined time after the initial dose of the first drug.

3. The method of claim 2, wherein the method further comprises selectively actuating the microdelivery system to provide alternating doses of the first and second drugs in a predetermined pattern.

4. The method of claim 2, wherein the method comprises, more specifically, providing at least two doses of the first drug before the initial dose of the second drug.

5. The method of claim 2, wherein step (a) comprises, more specifically, selecting a microdelivery system having a third drug disposed in at least one of the plurality of compartments, and wherein the method further comprises;

(f) actuating the microdelivery system to provide an initial dose of the third drug at a predetermined time after the initial dose of the first drug.

6. The method of claim 5, wherein the method further comprises actuating the microdelivery system in a pattern to provide alternating doses of the first, second and third drugs.

7. The method of claim 1 wherein step (b) comprises, more specifically, attaching the microdelivery system to the animal/human such that step (c) provides a topical application.

8. The method of claim 1, wherein step (b) comprises, more specifically, disposing the microdelivery system into the rumen of a ruminant animal.

9. The method of claim 1, wherein step (b) comprises, more specifically, implanting the microdelivery system into the animal/human.

10. The method of claim 1, wherein step (c) comprises, actuating a plurality of compartments to provide the initial dose of the first drug.

11. The method according to claim 1, wherein the first drug is selected from the group consisting of permethrin, chlorpyrifos, diazinon, lambdacyhalothrin, pyrimiphos methyl, ivermectin, doramectin, moxidectin and insect growth regulators.

12. The method according to claim 1, wherein the method comprises, more specifically, disposing a dose in one of the compartments which is a mixture of a first drug and a second drug.

13. A method for automatic alternate dosing of at least two drugs in an animal, the method comprising:

a) selecting a microdelivery system having a plurality of compartments disposed therein for holding at least a first drug and a second drug;

b) administering the microdelivery system to the animal;

c) actuating the microdelivery system to provide an initial dose of the first drug from a compartment of the microdelivery system to the animal; and

d) actuating the microdelivery system to provide an initial dose of the second drug from a compartment of the microdelivery system to the animal at a predetermined time after the initial dose of the first drug.

14. The method of claim 13, further comprising:

e) actuating the microdelivery system to provide a second dose of the first drug at a second predetermined time after the initial dose of the second drug.

15. The method of claim 14, further comprising:

f) actuating the microdelivery system to provide a second dose of the second drug at a third predetermined time after the second dose of the first drug.

16. The method of claim 15, wherein the method further comprises delivering additional doses of the first and second drugs in an alternating pattern, each dose being spaced a predetermined period of time.

17. The method of claim 13, wherein the method comprises, more specifically, delivering a second dose of the first drug prior to the initial dose of the second drug.

18. The method of claim 13, wherein step (a) comprises, more specifically, selecting a microdelivery system having compartments for storing first, second and third drugs.

19. The method according to claim 18, wherein the method further comprises:

e) actuating the microdelivery system to provide an initial dose of the third drug at a third predetermined time after the initial dose of the second drug.

20. The method according to claim 19, further comprising:

f) actuating the microdelivery system to provide a second dose of the second drug at a fourth predetermined time after the second dose of the first drug.

21. The method of claim 20, wherein the method further comprises delivering additional doses of the first and second drugs in an alternating pattern, each dose being delivered at a predetermined period of time subsequent to a prior dose.

22. The method of claim 13, wherein the step (a) comprises, more specifically, providing one of the compartments with a first quantity of the first drug and providing a plurality of the remaining compartments with a second quantity of the first drug which is less than the first quantity.

23. The method of claim 22, wherein the method further comprises releasing the compartments having the second quantity of the first drug at intervals sufficiently distant from one another so that the amount of the first drug available to the animal is substantially the same immediately after each dose of the first drug as the first quantity.

24. The method of claim 22, wherein step (a) further comprises, providing one of the compartments with a first quantity of the second drug and providing a plurality of the remaining compartments with a second quantity of the second drug which is less than the first quantity.

25. The method of claim 22, wherein step (a) further comprises, providing one of the compartments with a first quantity of the second drug and providing a plurality of the remaining compartments with a second quantity of the second drug which is greater than the first quantity.

26. The method of claim 13, wherein the step (a) comprises, more specifically, providing one of the compartments with a first quantity of the first drug and providing a plurality of the remaining compartments with a second quantity of the first drug which is greater than the first quantity.

27. The method of claim 26, wherein step (a) further comprises, providing one of the compartments with a first quantity of the second drug and providing a plurality of the remaining compartments with a second quantity of the second drug which is greater than the first quantity.

28. The method of claim 13, wherein step (a) comprises, more specifically, providing different quantities of the first and second drugs in the compartments, and wherein the method further comprises, selectively releasing the compartments to obtain a desired level of the first and second drugs within the animal.

29. The method of claim 13, wherein the method further comprises controlling the quantity of the first and second drugs within the animal by selectively controlling when each compartment releases the drug contained therein.

30. The method of claim 13, wherein steps (c) and (d) result in available levels of the first and second drugs to the animal, and wherein the method further comprises, delivering additional doses of the first and second drugs in such a manner to increase the levels of the drugs during seasonal parasite infestations.

31. The method of claim 13, wherein step (b) comprises, more specifically, implanting the microdelivery system within the animal.

32. The method of claim 13, wherein step (b) comprises, more specifically, topically attaching the microdelivery system to the animal.

33. The method of claim 13, wherein step (b) comprises, more specifically, disposing the microdelivery system within the stomach of the animal.

34. The method of claim 13, wherein the first drug is selected from the group consisting essentially of permethrin, chlorpyrifos, diazinon, permethrin, chlorpyrifos, diazinon, lambdacyhalothrin, pyrimiphos methyl, ivermectin, doramectin, and moxidectin.

35. The method of claim 34, wherein the second drug is selected from the group consisting essentially of permethrin, chlorpyrifos, diazinon, lambdacyhalothrin, pyrimiphos methyl, ivermectin, doramectin, and moxidectin.

36. A method for automatic alternate dosing of at least two drugs in an animal/human, each of the drugs having an efficacy threshold level for the animal/human, the method comprising:

a) selecting a microdelivery system having at least two compartments for holding at least first and second drugs;

b) administering the microdelivery system to the animal/human;

c) releasing a first dose of the first drug from the microdelivery system in sufficient quantity to exceed the efficacy threshold for the first drug for the animal/human; and

d) releasing a first dose of the second drug from the microdelivery system in sufficient quantity to exceed the efficacy threshold of the second drug for the animal/human, while the level of the first drug remains above the efficacy threshold for the first drug.

37. The method for alternate dosing of at least two drugs of claim 36, wherein the method further comprises:

e) releasing a second dose of the first drug from the microdelivery system in sufficient quantity so that the total quantity of the first drug administered to the animal/human exceeds the efficacy threshold for the first drug while the level of the second drug remains above the efficacy threshold for the second drug.

38. The method for alternate dosing of at least two drugs of claim 37, wherein the method further comprises:

f) releasing a second dose of the second drug from the microdelivery system in sufficient quantity so that the total quantity of the second drug administered to the animal/human exceeds the efficacy threshold for the second drug while the level of the first drug remains above the efficacy threshold for the first drug.

39. The method for alternate dosing of at least two drugs of claim 38, wherein the second dose of the first drug is released while the level of the first drug administered to the animal/human remains above the efficacy threshold for the first drug.

40. The method for alternate dosing of at least two drugs of claim 38, wherein the second dose of the second drug is released while the level of the second drug remains above the efficacy threshold for the second drug.

41. The method for alternate dosing of at least two drugs of claim 36, wherein step (a) comprises, more specifically, selecting a microdelivery system having at least two compartments for holding at least first and second drugs, and a circuit programmed to release the first and second drugs at predetermined intervals.

42. The method for alternate dosing of at least two drugs of claim 41, further comprising programming the microdelivery system to release an initial dose of the first drug in sufficient quantity that the first drug provided to the animal/human will remain at a level exceeding the efficacy threshold for the first drug until the second drug is released.

43. The method for alternate dosing of at least two drugs of claim 36, wherein step (a) comprises, more specifically, selecting a microdelivery system having a plurality of compartments therein, each compartment holding a single dose of one of the first and second drugs.

44. The method for alternate dosing of at least two drugs of claim 43, wherein the method further comprises selectively actuating the compartments to alternatingly release doses of the first and second drugs until all of the compartments holding the first and second drugs have been actuated.

45. The method for alternate dosing of at least two drugs of claim 36, wherein step (b) comprises attaching the microdelivery system to the animal/human so as to provide topical delivery when a dose is released.

46. The method for alternate dosing of at least two drugs of claim 36, wherein step (b) comprises disposing the microdelivery system in the rumen of an animal.

47. The method for alternate dosing of at least two drugs of claim 36, wherein step (b) comprises implanting the microdelivery system to the animal/human so as to provide internal delivery when a dose is released.

48. The method for alternate dosing of at least two drugs of claim 36, wherein step (b) comprises selecting a microdelivery system having at least compartment containing a hormone, and wherein the method comprises actuating said at least one compartment subsequent to the initial dose of the first drug.

49. The method for alternate dosing of at least two drugs of claim 36, wherein the method further comprises remotely activating the microdelivery system.

50. The method of claim 36, wherein the first drug is selected from the group consisting essentially of permethrin, chlorpyrifos, diazinon, lambdacyhalothrin, pyrimiphos methyl, ivermectin, doramectin, and moxidectin.

51. The method of claim 50, wherein the second drug is selected from the group consisting essentially of permethrin, chlorpyrifos, diazinon, lambdacyhalothrin, pyrimiphos methyl, ivermectin, doramectin, and moxidectin.

52. The method of claim 36, wherein the first drug is selected from the group consisting essentially of insect growth regulators.

53. The method of claim 52, wherein the second drug is selected from the group consisting essentially of insect growth regulators.