Glass cartridge for injection syringe prefilled with pharmaceutical liquid

• US 5,782,815 A
• Filed: 01/24/1996
• Issued: 07/21/1998
• Est. Priority Date: 01/26/1995
• Status: Expired due to Term

• Current Assignee: Schering Ag (Merck & Co., Inc.), Taisei Kako Co. Ltd.
• Original Assignee: Nihon Schering KK (Bayer AG), Yuji Yanai
• Inventors: Kakimi, Mitsuru, Yanai, Yuji
• Primary Examiner(s): STRIGHT, RONALD K
• Application Number:
  US08/590,479
• Time in Patent Office: 909 Days
• Field of Search: 604/181, 604/187, 604/195, 604/199, 604/218, 604/220, 604/221, 604/222, 604/225, 604/232, 604/240, 604/241, 604/242, 604/243, 604/905, 604/283, 604/227, 215/317, 215/320, 215/324, 215/326, 215/329, 215/335, 215/337, 215/340, 215/341, 215/343, 215/344, 215/350, 215/352, 215/349, 215/DIG. 3, 222/386
• US Class Current: 604/218
• CPC Class Codes: A61J 1/062 Carpules
• CPC Class Codes: A61M 2005/3139 Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
• CPC Class Codes: A61M 2005/31506 formed as a single piece, e.g. moulded
• CPC Class Codes: A61M 5/28 Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
• CPC Class Codes: A61M 5/3129 Syringe barrels A61M5/3205 and A61M5/50 take precedence
• CPC Class Codes: A61M 5/3134 characterised by constructional features of the distal end, i.e. end closest to the tip of the needle cannula

Abstract

A glass cartridge (C) for an injection syringe prefilled with pharmaceutical liquid, wherein a glass barrel (1a) having an entrance end (1i) portion and the exit end (1e) portion are formed. Further, a stopper serving also as a piston is fitted into the glass barrel (1a), and a gasket (3) is provided on the exit end (1e). A lure lock lid (4) and a lid holder (5) are provided on the exit and (1e). An inner member (41) of the lure lock lid (4) is preferably made of polypropylene, PP while its outer member (42) is preferably made of polybutylene terephthalate, PBT. The lid holder (5) and a flanged cap (6) are preferably made of polycarbonate, PC, and the stopper (2) and the gasket (3) are made of isobutylene-isoprene copolymer rubber, IIR. Even when the glass cartridge for an injection syringe is prefilled with pharmaceutical liquid and subjected to pressurized steam sterilization (121° C.×20 min), alkaline metallic ions will be eluted.

Claims

1. A glass cartridge for an injection syringe prefilled with pharmaceutical liquid, said cartridge comprising:

a barrel formed of a heat resistant glass, said barrel being provided with a first undercut on an outer surface of an exit end portion of said barrel, and a second undercut on an outer surface of an entrance end portion of said barrel;

a lid holder disposed on said exit end portion of said barrel in engagement with said first undercut, said lid holder being formed of a flexible material;

a gasket disposed between said lid holder and an exit end surface of said barrel, said gasket being formed of a soft material;

a lure lock lid provided between said gasket and said lid holder, said lure lock lid being formed of multiple pieces of flexible material;

a stopper disposed in said barrel, said stopper also serving as a piston; and

a flanged cap disposed on said entrance end portion of said barrel in engagement with said second undercut, said flanged cap being formed of a flexible material and including a flange portion, having a central axis, and a hollow cylindrical portion extending axially from a side face of said flange portion,

wherein said entrance end portion of said barrel includes a stepped portion forming a reduced diameter portion, and said flanged cap is received on said reduced diameter portion such that an outer peripheral surface of said cylindrical portion does not project radially beyond said outer peripheral surface of said barrel at any location of said barrel other than said flange portion.

2. The glass cartridge as claimed in claim 1, wherein said barrel is a linear transparent glass tube formed of a boro-silicate glass.

3. The glass cartridge as claimed in claim 2, wherein said cylindrical portion of said flanged cap includes a plurality of discrete pull-out prevention projections aligned in a plane substantially perpendicular to the central axis of said flange portion, and said projections are spaced circumferentially so as to permit said second undercut to pass upon application of said flanged cap on said entrance end of said barrel.

4. The glass cartridge as claimed in claim 3, wherein an outer diameter of said cylindrical portion is less than or equal to the outer diameter of said barrel.

5. The glass cartridge as claimed in claim 4, wherein said lid holder and said flanged cap are formed of polycarbonate resins.

6. The glass cartridge as claimed in claim 1, wherein said lid holder and said flanged cap are formed of polycarbonate resins.

7. The glass cartridge as claimed in claim 1, wherein the diameter of said barrel is constant along said barrel except at said reduced diameter portion so as to avoid inducing thermal stresses therein.

20. The glass cartridge as claimed in claim 5, wherein said lid holder and said flanged cap are formed of polycarbonate resins.

8. A glass cartridge for an injection syringe prefilled with pharmaceutical liquid, said cartridge comprising:

a barrel formed of a heat resistant glass, said barrel being provided with a first undercut on an outer surface of an exit end portion of said barrel, and a second undercut on an outer surface of an entrance end portion of said barrel;

a lid holder disposed on said exit end portion of said barrel in engagement with said first undercut, said lid holder being formed of a flexible material;

a gasket disposed between said lid holder and an exit end surface of said barrel, said gasket being formed of a soft material;

a lure lock lid provided between said gasket and said lid holder, said lure lock lid being formed of a flexible material;

a stopper disposed in said barrel, said stopper also serving as a piston; and

a flanged cap disposed on said entrance end portion of said barrel in engagement with said second undercut, said flanged cap being formed of a flexible material,

wherein said lure lock lid comprises an inner lure lock lid and an outer lure lock lid laminated to said inner lure lock lid, said inner lure lock lid contacts said gasket and is formed of polyolefin resin, said outer lure lock lid contacts said lid holder and is formed of a resin selected from a thermoplastic polyester resin, a polyamide resin and a polysulfon resin, mixed resins of two or more said resins, and mixed resins thereof with an ethylene-vinyl alcohol copolymer.

9. The glass cartridge as claimed in claim 8, wherein said barrel is a linear transparent glass tube formed of a boro-silicate glass.

10. The glass cartridge as claimed in claim 9, wherein said flanged cap includes a flange portion, having a central axis, and a hollow cylindrical portion extending axially from a face of said flange portion,

said cylindrical portion includes a plurality of discrete pull-out prevention projections aligned in a plane substantially perpendicular to the central axis of said flange portion, and

said projections are spaced circumferentially so as to permit said second undercut to pass upon application of said flanged cap on said entrance end of said barrel.

11. The glass cartridge as claimed in claim 10, wherein an outer diameter of said cylindrical portion is less than or equal to the outer diameter of said barrel.

12. The glass cartridge as claimed in claim 11, wherein said lid holder and said flanged cap are formed of polycarbonate resins.

13. The glass cartridge as claimed in claim 8, wherein said lid holder and said flanged cap are formed of polycarbonate resins.

14. The glass cartridge as claimed in claim 8, wherein said barrel is of a constant diameter at said exit end portion so as to avoid inducing thermal stresses therein.

15. A glass cartridge for an injection syringe prefilled with pharmaceutical liquid, said cartridge comprising:

a barrel formed of a heat resistant glass, said barrel being provided with a first undercut on an outer surface of an exit end portion of said barrel, and a second undercut on an outer surface of an entrance end portion of said barrel;

a lid holder disposed on said exit end portion of said barrel in engagement with said first undercut, said lid holder being formed of a flexible material;

a gasket disposed between said lid holder and an exit end surface of said barrel, said gasket being formed of a soft material;

a lure lock lid provided between said gasket and said lid holder, said lure lock lid being formed of a flexible material and comprising an inner lure lock lid and an outer lure lock lid,

said inner lure lock lid including an outer cylindrical part disposed in said exit end portion of said barrel and having a collar at one end thereof, a conical bottom portion extending from the other end of said outer cylindrical part, an inner cylinder extending along a central axis of said bottom portion from a converging end of said conical bottom portion so as to define a long and narrow tubular form, and an annular engaging projection surrounding a base portion of said inner cylinder,

said outer lure lock lid having a form similar to that of said inner lure lock lid and being provided with an inner cylinder having an inner diameter of a size such that said inner cylinder of said inner lure lock lid can be inserted into said inner cylinder of said outer lure lock lid, and an annular projection projecting from an inner surface of said inner cylinder of said outer lure lock lid and engaged with said annular engaging projection of said inner lure lock lid;

a stopper disposed in said barrel, said stopper also serving as a piston; and

a flanged cap disposed on said entrance end portion of said barrel in engagement with said second undercut, said flanged cap being formed of a flexible material.

16. The glass cartridge as claimed in claim 15, wherein said barrel is a linear transparent glass tube formed of a boro-silicate glass.

17. The glass cartridge as claimed in claim 16, wherein said flanged cap includes a flange portion, having a central axis, and a hollow cylindrical portion extending axially from a face of said flange portion,

said cylindrical portion includes a plurality of discrete pull-out prevention projections aligned in a plane substantially perpendicular to the central axis of said flange portion, and

said projections are spaced circumferentially so as to permit said second undercut to pass upon application of said flanged cap on said entrance end of said barrel.

18. The glass cartridge as claimed in claim 17, wherein an outer diameter of said cylindrical portion is less than or equal to the outer diameter of said barrel.

19. The glass cartridge as claimed in claim 18, wherein said lid holder and said flanged cap are formed of polycarbonate resins.

21. The glass cartridge as claimed in claim 15, wherein said barrel is of a constant diameter at said exit end portion so as to avoid inducing thermal stresses therein.