Method and apparatus for improving the function of sensory cells

• US 5,782,873 A
• Filed: 08/27/1996
• Issued: 07/21/1998
• Est. Priority Date: 10/11/1995
• Status: Expired due to Term

• Current Assignee: Trustees of Boston University
• Original Assignee: Trustees of Boston University
• Inventors: Collins, James J.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/703,674
• Time in Patent Office: 693 Days
• Field of Search: 607/46, 607/62, 607/2, 128/741, 128/744
• US Class Current: 607/2
• CPC Class Codes: A61F 7/00 Heating or cooling appliances for medical or therapeutic treatment of the human body heating or cooling means in connection with bedsteads or mattresses A47C21/00 ; massage, therapeutic baths A61H; hyperthermia using electric or magnetic fields or ultrasound A61N; electric heating elements H05B
• CPC Class Codes: A61N 1/36003 of motor muscles, e.g. for walking assistance
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/36036 of the outer, middle or inner ear
• CPC Class Codes: A61N 2/00 Magnetotherapy
• CPC Class Codes: A61N 2/006 for magnetic stimulation of nerve tissue
• CPC Class Codes: A61N 5/06 using light
• CPC Class Codes: A61N 7/00 Ultrasound therapy lithotripsy A61B17/22, A61B17/225; massage using supersonic vibration A61H23/00 ; using ultrasound for introducing media into the body A61M37/0092

Abstract

Method and system for enhancing the function of sensory cells are disclosed. The method comprises locating a sensory cell area associated with the sensory cell whose function is to be enhanced and inputting a bias signal to the sensory cell area. The apparatus comprises a signal processor for producing a bias signal and an input device for inputting the bias signal to a sensory cell area associated with a sensory cell whose function is to be enhanced. Inputting the bias signal to a sensory cell area effectively lowers the threshold of sensory cells with which the sensory cell area is associated.

Claims

1. A method for enhancing the ability of a threshold-based sensory cell to respond to a subthreshold stimulus comprising the steps of:

a) locating an area of the body associated with a sensory cell area;

b) generating a bias signal; and

,

c) inputting the bias signal to the located area wherein the bias signal causes the threshold of sensory cells in the sensory cell area to be exceeded in response to the subthreshold stimulus thereby effectively lowering the threshold of the sensory cells in the sensory cell area, wherein the step of generating a bias signal further comprises the step of transducing the subthreshold stimulus to the sensory cell area into an electrical signal and generating the bias signal in response to the electrical signal.

2. The method of claim 1 wherein the located area comprises a nerve.

3. The method of claim 1 wherein the located area comprises the sensory cell area.

4. The method of claim 1 wherein the located area comprises a muscle.

5. The method of claim 1 wherein the bias signal comprises a noise signal.

6. The method of claim 1 further comprising:

sensing said subthreshold stimulus;

wherein the bias signal comprises an electrical signal which is modulated in response to the sensed subthreshold stimulus.

7. The method of claim 1 wherein the bias signal comprises a periodic signal.

8. The method of claim 1 wherein the bias signal comprises a high frequency deterministic signal.

9. The method of claim 1 wherein the bias signal comprises a magnetic field.

10. The method of claim 9 wherein the magnetic field comprises a randomly fluctuating field intensity.

11. The method of claim 1 wherein the bias signal comprises a mechanical stimulus.

12. The method of claim 1 wherein the bias signal comprises a predetermined signal.

13. The method of claim 12 wherein the predetermined signal is calibrated according to a function which the threshold-based sensory cell performs.

14. A method for enhancing the ability of a threshold-based sensory cell to respond to a subthreshold stimulus comprising the steps of:

a) sensing the subthreshold stimulus to a sensory cell area;

b) generating an electrical signal in response to the subthreshold stimulus; and

c) inputting the electrical signal to the sensory cell area wherein the electrical signal causes the threshold of sensory cells in the sensory cell area to be exceeded thereby effectively lowering the threshold of the sensory cells in the sensory cell area.

15. The method of claim 14 further comprising the step of:

d) determining an optimal level for a parameter of the electrical signal, wherein the step of inputting an electrical signal comprises inputting an electrical signal having the parameter with the optimal level.

16. The method of claim 15 wherein the parameter comprises frequency.

17. The method of claim 15 wherein the parameter comprises amplitude.

18. The method of claim 14 wherein the step of generating comprises generating a noise signal in response to the sensed subthreshold stimulus.

19. The method of claim 14 wherein the step of generating comprises generating the electrical signal in response to the subthreshold stimulus, and modulating the electrical signal in response to the sensed subthreshold stimulus.

20. The method of claim 14 wherein the step of inputting comprises locating a sensory nerve associated with the sensory cell area, implanting a nerve cuff around the located sensory nerve and inputting the electrical signal through the implanted nerve cuff.

21. The method of claim 14 wherein the step of inputting comprises locating a sensory nerve associated with the sensory cell area, positioning a surface electrode on the exterior of the body in an area associated with the sensory cell area and inputting the electrical signal through the surface electrode.

22. The method of claim 14 wherein the step of inputting comprises locating the sensory cell area, implanting electrodes at the sensory cell area and inputting the electrical signal through the implanted electrodes.

23. The method of claim 14 wherein the step of inputting comprises positioning a muscle stimulator in an area around a muscle associated with the sensory cell area and inputting the electrical signal through the muscle stimulator, wherein the muscle stimulator stimulates a muscle thereby stimulating the sensory cell with which the muscle is associated.

24. The method of claim 23 wherein the muscle stimulator mechanically stimulates the muscle.

25. The method of claim 14 wherein the step of inputting comprises positioning a tendon stimulator in an area around a tendon associated with the sensory cell area and inputting the electrical signal through the tendon stimulator, wherein the tendon stimulator stimulates a tendon thereby stimulating the sensory cell with which the tendon is associated.

26. The method of claim 25 wherein the tendon stimulator mechanically stimulates the tendon.

27. The method of claim 14 wherein the sensory cell area comprises at least one sensory neuron.

28. The method of claim 14 wherein the sensory cell area comprises at least one sensory receptor.

29. The method of claim 14 wherein the sensory cell area is associated with the proprioceptive system.

30. The method of claim 14 wherein the sensory cell area is associated with the urinary tract.

31. The method of claim 30 wherein the sensory cell area is associated with the bladder.

32. The method of claim 14 wherein the sensory cell area is associated with the circulatory system.

33. The method of claim 32 wherein the sensory cell area is associated with the heart muscle.

34. The method of claim 14 wherein the sensory cell area is associated with the respiratory system.

35. The method of claim 14 wherein the sensory cell area is associated with the auditory system.

36. The method of claim 14 wherein the sensory cell area is associated with the visual system.

37. The method of claim 14 wherein the sensory cell area is associated with the vibration-sensation system.

38. The method of claim 14 wherein the sensory cell area is associated with the temperature-sensation system.

39. The method of claim 14 wherein the sensory cell area is associated with the touch-pressure sensation system.