Whole blood and platelet leukocyte filtration method

• US 5,783,094 A
• Filed: 05/07/1997
• Issued: 07/21/1998
• Est. Priority Date: 04/13/1995
• Status: Expired due to Fees

• Current Assignee: Teva Medical Ltd (Teva Pharmaceutical Industries Limited)
• Original Assignee: Teva Medical Ltd (Teva Pharmaceutical Industries Limited)
• Inventors: Sazan, Roni, Kraus, Menahem A., Yonath, Jacob, Gamlieli, Yephet
• Primary Examiner(s): Kim, John
• Application Number:
  US08/813,213
• Time in Patent Office: 440 Days
• Field of Search: 210/645, 210/650, 210/767, 210/504, 210/506
• US Class Current: 210/767
• CPC Class Codes: A61M 2202/0042 filtrate, i.e. the fluid passing through the filter
• CPC Class Codes: A61M 2202/0057 retained by adsorption
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: A61M 2202/0439 White blood cells; Leucocytes
• CPC Class Codes: B01D 2323/30 Cross-linking
• CPC Class Codes: B01D 39/1623 of synthetic origin
• CPC Class Codes: B01D 67/0088 Physical treatment with compounds, e.g. swelling, coating or impregnation
• CPC Class Codes: D06M 15/03 Polysaccharides or derivatives thereof
• CPC Class Codes: D06M 15/05 Cellulose or derivatives thereof
• CPC Class Codes: D06M 15/09 Cellulose ethers
• CPC Class Codes: D06M 15/11 Starch or derivatives thereof

Abstract

A method for selectively removing leukocytes from a suspension which also contains platelets, such as a platelet concentrate or whole blood. The method includes passing the suspension through a filter which includes a polysaccharide-type coating. The coating may include one or more of hydroxypropylmethyl cellulose, hydroxybutylmethyl cellulose, dextran and hydroxyethyl starch. Also provided is a filter for selectively removing leukocytes from a suspension which also contains platelets. The filter includes a substrate which is coated with a polysaccharide-type composition.

Claims

1. A method for selectively removing leukocytes from a suspension which also contains platelets, comprising the step of:

passing the suspension through a filter featuring a substantially neutral coating including at least one species selected from the group consisting of hydroxypropyl cellulose, hydroxyethyl cellulose, hydroxypropylmethyl cellulose, hydroxybutylmethyl cellulose, dextran and hydroxyethyl starch, said coating being substantially retained by said filter during the step of passing the suspension through said filter such that said filter selectively retains the leukocytes and passes the platelets.

2. The method of claim 1, wherein said coating includes hydroxypropyl cellulose.