Method for quantifying alcohol catabolism

• US 5,783,449 A
• Filed: 10/25/1996
• Issued: 07/21/1998
• Est. Priority Date: 10/25/1996
• Status: Expired due to Fees

• Current Assignee: Kuznetsov, Oleg
• Original Assignee: Kuznetsov, Oleg
• Inventors: Kuznetsov, Oleg
• Primary Examiner(s): ALEXANDER, LYLE
• Application Number:
  US08/736,671
• Time in Patent Office: 634 Days
• Field of Search: 436/132, 436/900, 422/89
• US Class Current: 436/132
• CPC Class Codes: G01N 2800/307 Drug dependency, e.g. alcoholism
• CPC Class Codes: G01N 33/4972 Determining alcohol content for vehicle safety devices B60K28/06
• CPC Class Codes: G01N 33/98 involving alcohol, e.g. ethanol in breath
• CPC Class Codes: Y10S 436/90 Breath testing
• CPC Class Codes: Y10T 436/204165 Ethanol

Abstract

The method for quantifying Alcohol Breakdown Activity (ABA) in humans in vivo is developed to determine an efficiency of alcohol catabolism for any given individual. Unlike other related methods, Index-K uses a biological regularity of ABA and employs a third dimension for integrating the multiple pharmacokinetical data into a single value. As expected, it allows for the discrimination between human differences, including gender and personal levels of alcohol dependency. Its use of pharmacokinetical data from ethanol catabolism makes it absolutely specific to alcohol--a major cause of alcohol disorder. This feature allows us to help diagnose alcoholism even in cases where traditional methods used to evaluate harmful alcohol consumption have failed.

Claims

1. A method for quantifying an individual'"'"'s catabolic activity for alcohol, comprising the steps of:

a. providing a single dose of alcohol of standardized alcohol intake to an individual;

b. repeatedly measuring the subject'"'"'s Breath (Blood) Alcohol Concentration before it reaches zero;

c. based on the measurements obtained in step b, plotting the alcohol concentration levels for an individual versus time and using computerized techniques to obtain value of the Area Under the Curve (AUC) for the ascending and descending parts of the plotted data;

d. dividing the individual'"'"'s alcohol eliminition AUC as determined by the descending plotted part of the curve in step c by the plotted AUC for the ascending part of the pharmacokinetical curve to obtain a representation of alcohol catabolism presented as an Index-K value; and

e. determining said Index-K according to the formula;

##EQU1## wherein AUCelim is defined as the elimination of ethanol and is equal to the descending segment of the plotted curve, and the term AUCabs-distr is defined as the sum of the absorption-distribution of ethanol and is equal to the area under the plotted ascending part of the pharmacokinctical curve.

2. The invention as claimed in claim 1, wherein said dose of standardized alcohol in step a is calculated by one of two commonly used method:

based on the total body water volume required to achieve a 80 mg/dl blood alcohol concentration, or by 0.75 or 0.65 ml per one Kg of total body weight for male and female individuals, respectively.