Fluid delivery apparatus and method

• US 5,785,688 A
• Filed: 05/07/1996
• Issued: 07/28/1998
• Est. Priority Date: 05/07/1996
• Status: Expired due to Term

• Current Assignee: Microlin LLC
• Sponsoring Entity: Ceramatec, Inc.
• Inventors: Davis, James O., Joshi, Ashok V., di Palma, Giorgio, Wold, Truman
• Primary Examiner(s): Rimell, Sam
• Assistant Examiner(s): Racunas, Robert V.
• Time in USPTO: 812 Days
• Field of Search: 604/131, 604/132, 604/140, 604/141, 604/145-147, 604/153, 604/410, 604/416
• US Class Current: 604/141
• CPC Class Codes: A61M 2005/14204 : with gas-producing electrochemical cell
• CPC Class Codes: A61M 2005/14252 : with needle insertion means
• CPC Class Codes: A61M 35/006 : Absorbent pads, e.g. swabs, containing a liquid, e.g. in a rupturable reservoir absorbent pads, e.g. swabs, for medical use, in general A61F13/00, e.g. A61F13/38
• CPC Class Codes: A61M 5/14244 : adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: A61M 5/14248 : of the skin patch type
• CPC Class Codes: A61M 5/14593 : the diaphragm being actuated by fluid pressure

Abstract

An apparatus (120) useful for, among other things, subcutaneous drug delivery includes a housing (124), a fluid reservoir (154) disposed within the housing for storing the fluid, a pump or pressurized chamber for pressurizing a driving gas and exerting a force on the fluid reservoir to expel the fluid reservoir'"'"'s contents, and a needle (150) or absorbent pad fluidically communicating with the reservoir. The apparatus may further include a pump activation mechanism such as a button and an electrical circuit such that pushing the button activates a circuit and connects a battery (138) to a pump (126), and a pump control mechanism such as electrical circuitry to control the voltage gradient to a pump to control fluid delivery.

Claims

1. An apparatus for delivering a fluid, said apparatus comprising:

a housing;

a displaceable membrane disposed within said housing, dividing a portion of said housing into a first chamber and a second chamber, said first chamber formed in part, of said housing, said first chamber for containing fluid for delivery and having a port in fluid communication with said first chamber, and said second chamber for containing a driving gas, said displaceable membrane being impermeable to the driving gas;

a pump for pressurizing driving gas in said second chamber, thereby exerting a force on said displaceable membrane, thus expelling fluid contained within said first member from said port, said pump comprising an electrochemical gas generation cell; and

means for delivering fluid from said port to a desired location.

2. The apparatus of claim 1, further comprising a pump activation mechanism.

3. The apparatus of claim 1, further comprising a pump control mechanism.

4. The apparatus of claim 1, further comprising a flow control mechanism for controlling the delivery of the fluid from the apparatus.

5. The apparatus of claim 4, wherein said flow control mechanism comprises electrical circuitry controlling said pump.

6. The apparatus of claim 1, wherein said means for delivering fluid is a needle, and the apparatus further comprises a needle extension mechanism such that, upon activation, the needle extends out of said housing.

7. The apparatus of claim 6, wherein the apparatus further comprises a needle retraction mechanism such that upon termination the needle is retractable within said housing.

8. The apparatus of claim 1, wherein said means for delivering a fluid is a needle, and the apparatus further comprises a needle activation mechanism and a pump activation mechanism such that activation of both mechanisms occurs simultaneously.

9. The apparatus of claim 1, further comprising an adhesive layer disposed on the surface of said housing.

10. The apparatus of claim 9, wherein the adhesive layer contains a pharmaceutically active agent, said pharmaceutically active agent selected from the group of local anesthetics, antiseptics, and mixtures thereof.

11. The apparatus of claim 1, wherein said means for delivering a fluid is a needle, and the apparatus further comprises a needle depth adjustment mechanism for adjusting the length the needle extends from the housing.

12. The apparatus of claim 3, wherein said pump control mechanism comprises electrical circuitry to adjust the voltage to the pump such that the flow of the driving gas is controlled and thus the flow of the fluid is controlled.

13. The apparatus of claim 12, further comprising a timer such that the flow of said delivery fluid and the flow of the first bladder contents can be timed.

14. The apparatus of claim 1, wherein the housing comprises a substantially inexpandable outer shell.

15. The apparatus of claim 1, wherein the housing comprises a generally annular outer shell with the pump and means for delivering fluid disposed generally in the center of the housing.

16. The apparatus of claim 1, wherein said pump comprises an oxygen pump for transferring atmospheric oxygen into said housing and said driving gas comprises oxygen.

17. The apparatus of claim 1, wherein said pump comprises an electrolytic cell comprising a pair of electrodes suspended in an electrolyte and a voltage source such that when voltage is applied to the pair of electrodes, a gas is formed in the electrolyte which exerts a force that expels the liquid.

18. The apparatus of claim 1, wherein said pump comprises a Galvanic cell.

19. The apparatus of claim 1 further comprising a second bladder having an interior, an exterior, and a port extending between said interior and exterior, said second bladder disposed within said housing proximal said first bladder and formed to contain a second fluid within the bladder'"'"'s interior, wherein said pump pressurizes a driving gas in contact with the second bladder'"'"'s exterior, said driving gas thereby exerting a force on the exterior of said first bladder, deforming said exterior, and expelling fluid from the first bladder'"'"'s interior through said port delivering fluid from the first bladder'"'"'s port to the desired location.

20. The apparatus of claim 1 further comprising a pressure relief valve associated with said second chamber.

21. The apparatus of claim 20 further comprising an inlet port in fluid communication with said first chamber.