Reduction of adhesions using controlled delivery of active oxygen inhibitors
First Claim
1. A fluent composition for the inhibition of a condition selected from the group consisting of adhesion formation, keloid or hypertrophic scarring, hypertrophy which obstructs ducts, inflammation of joints and endometriosis or for repair of structures selected from the group consisting of arteries, nerve sheaths, the spinal column and spinal disks at a tissue site comprising an effective amount of one or more inhibitors of active oxygen species and a material capable of polymerizing to form a barrier at the tissue site,wherein the composition is fluent when applied to the tissue site, the material is present in a range of 0.5% to 80% by weight of the composition and the inhibitor is selected from the group consisting of superoxide dismutase, catalase, allopurinol, verapamil, and combinations thereof.
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Accused Products
Abstract
SOD and other active oxygen inhibitors are directly applied in combination with a barrier material at local sites of tissue injury to prevent or decrease formation of adhesions and undesirable proliferation of cells. Preferred barrier materials are polymeric hydrogels providing controlled release of AOI which are directly applied to the afflicted tissue. Examples demonstrate the effects of SOD on pelvic adhesions in the rat when administered by intraperitoneal (I.P.) bolus and by localized sustained release from a topically applied hydrogel system.
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Citations
42 Claims
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1. A fluent composition for the inhibition of a condition selected from the group consisting of adhesion formation, keloid or hypertrophic scarring, hypertrophy which obstructs ducts, inflammation of joints and endometriosis or for repair of structures selected from the group consisting of arteries, nerve sheaths, the spinal column and spinal disks at a tissue site comprising an effective amount of one or more inhibitors of active oxygen species and a material capable of polymerizing to form a barrier at the tissue site,
wherein the composition is fluent when applied to the tissue site, the material is present in a range of 0.5% to 80% by weight of the composition and the inhibitor is selected from the group consisting of superoxide dismutase, catalase, allopurinol, verapamil, and combinations thereof.
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7. A composition for inhibition of a condition selected from the group consisting of adhesion formation, keloid or hypertrophic scarring, hypertrophy which obstructs ducts, inflammation of joints and endometriosis or for repair of structures selected from the group consisting of arteries, nerve sheaths, the spinal column and spinal disks at a tissue site comprising an effective amount of one or more inhibitors of active oxygen species and a material which is fluent when applied to the tissue site and is polymerized at the tissue site to form a barrier at the tissue site,
wherein the material is present in a range of 0.5% to 80% by weight of the composition and the inhibitor is selected from the group consisting of superoxide dismutase, catalase, allopurinol, verapamil, and combinations thereof.
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14. A method for the inhibition of a condition selected from the group consisting of adhesion formation, keloid or hypertrophic scarring, hypertrophy which obstructs ducts, inflammation of joints and endometriosis or for repair of structures selected from the group consisting of arteries, nerve sheaths, the spinal column and spinal disks comprising administering a fluent composition comprising an effective amount of at least one inhibitor of active oxygen species in combination with a material capable of polymerizing to form a barrier at the tissue site,
wherein the material is present in a range of 0.5% to 80% by weight of the composition and the inhibitor is selected from the group consisting of superoxide dismutase, catalase, allopurinol, verapamil, and combinations thereof.
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30. A method of inhibiting secondary adhesion formation after adhesiolysis of an adhesion on a tissue site, comprising administering to the site a fluent composition comprising an effective amount of at least one inhibitor of active oxygen species in combination with a material capable of polymerizing to form a barrier at the tissue site,
wherein the material is present in a range of 0.5% to 80% by weight of the composition and the inhibitor is selected from the group consisting of superoxide dismutase, catalase, allopurinol, verapamil, and combinations thereof.
Specification