Human prostatic specific reductase
First Claim
1. An isolated polynucleotide comprising a polynucleotide sequence which is a member selected from the group consisting of:
- (a) a polynucleotide sequence encoding a polypeptide comprising amino acid 2 to 316 of SEQ ID NO;
2; and
(b) the complement of (a).
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Accused Products
Abstract
A human prostatic specific reductase polypeptide and polynucleotides encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides as a diagnostic marker for prostate cancer and as an agent to determine if the prostate cancer has metastasized. Also disclosed are antibodies specific to the prostatic specific reductase polypeptide which may be used to target prostate cancer cells and be used as part of a prostate cancer vaccine. Methods of screening for agonists and antagonists for the polypeptide and therapeutic uses of the antagonists are also disclosed.
31 Citations
21 Claims
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1. An isolated polynucleotide comprising a polynucleotide sequence which is a member selected from the group consisting of:
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(a) a polynucleotide sequence encoding a polypeptide comprising amino acid 2 to 316 of SEQ ID NO;
2; and(b) the complement of (a). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An isolated polynucleotide comprising a polynucleotide sequence which is a member selected from the group consisting of:
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(a) a polynucleotide sequence encoding the same mature polypeptide encoded by the human cDNA in ATCC Deposit No. 75913; and (b) the complement of (a). - View Dependent Claims (12, 13)
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14. An isolated polynucleotide comprising a polynucleotide sequence that will hybridize under stringent hybridization conditions with the full sequence of a member selected from the group consisting of:
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(a) a polynucleotide sequence encoding amino acids 2 to 316 of SEQ ID NO;
2; and(b) the complement of (a). - View Dependent Claims (15, 16, 17)
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18. An isolated polynucleotide comprising a polynucleotide sequence that will hybridize under stringent hybridization conditions with the full sequence of a member selected from the group consisting of:
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(a) a polynucleotide sequence encoding the polypeptide encoded by the human cDNA in ATCC Deposit No. 75913; and (b) the complement of (a). - View Dependent Claims (19, 20, 21)
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Specification