Line scan diffusion imaging

• US 5,786,692 A
• Filed: 08/16/1996
• Issued: 07/28/1998
• Est. Priority Date: 08/18/1995
• Status: Expired due to Term

• Current Assignee: Brigham and Women's Hospital Incorporated
• Original Assignee: Brigham and Women's Hospital Incorporated
• Inventors: Gudbjartsson, Hakon, Maier, Stephan E.
• Primary Examiner(s): Arana, Louis M.
• Application Number:
  US08/689,949
• Time in Patent Office: 711 Days
• Field of Search: 324/300, 324/306, 324/307, 324/309, 324/318, 128/653.3
• US Class Current: 324/307
• CPC Class Codes: G01R 33/4833 using spatially selective excitation of the volume of interest, e.g. selecting non-orthogonal or inclined slices
• CPC Class Codes: G01R 33/56341 Diffusion imaging

Abstract

Magnetic resonance imaging appparaus and methods, including providing selective radio frequency pulses including pairs of pulses, which define planes with an intersection that defines an imaging volume. The imaging volumes are part of a first image surface passing through the sample and having a spatial orientation that differs from the spatial orientation of the planes. The method further includes providing magnetic diffusion gradients in the sample which are associated with at least a subset of the volumes, and acquiring a series of nuclear magnetic resonance echo signals resulting from the intersection, with at least a subset of the echo signals being responsive to the gradients. The signals are processed to obtain an image that includes lines corresponding to the imaging volumes.

Claims

1. A magnetic resonance imaging method comprising:

providing a series of selective radio frequency pulses that includes a series of pairs of radio frequency pulses, which pairs each define a pair of planes that intersect at an intersection that defines an imaging volume, wherein the imaging volumes defined by the pairs are distinctly positioned and are part of a first image surface passing through the sample and having a spatial orientation that differs from the spatial orientation of the planes defined by the pairs,

providing magnetic diffusion gradients in the sample and associated with at least a subset of the imaging volumes,

acquiring a series of nuclear magnetic resonance echo signals resulting from the intersection of the planes in the step of providing a series of selective pulses, wherein at least a subset of the nuclear magnetic resonance echo signals are responsive to the influence of the diffusion gradients, and

processing the nuclear magnetic resonance echo signals acquired in the step of acquiring to obtain an image that includes lines corresponding to the imaging volumes defined by the pairs.

2. The imaging method of claim 1 wherein at least some of the individual imaging volumes in the first set of volumes overlap.

3. The imaging method of claim 2, wherein the volumes are defined in an interleaved sequence that separates in time the definition of spatially adjacent ones of the imaging volumes by defining others of the volumes during the period between the definitions of the adjacent ones of the volumes.

4. The imaging method of claim 3, further including, before the step of providing a series of selective radio frequency pulses, the step of providing a series of pairs of dummy radio frequency pulses, which pairs each define a pair of dummy planes that intersect at an intersection that defines a dummy volume, wherein the dummy volumes defined by the dummy pairs are located in the imaging surface, and wherein the step of providing a series of selective radio frequency pulses provides pairs of pulses that define ones of the imaging volumes that are coextensive with the dummy volumes.

5. The imaging method of claim 4, wherein the volumes are acquired in a series of successively offset sweeps across the image surface, and wherein a first of the offset sweeps is a dummy sweep.

6. The magnetic resonance imaging method of claim 3, wherein the total number of lines per image acquired is odd.

7. The imaging method of claim 1, wherein the step of providing a series of selective pulses alternately swaps the orientation of first and second successively defined pairs of the selective radio frequency pulses, such that the plane defined by the first pulse in time in the first of the successive pairs does not coincide within the sample with the plane defined by the last pulse in time in the second of the successive pairs.

8. The magnetic resonance imaging method of claim 7 wherein the step of acquiring is performed without any crusher gradients.

9. The imaging method of claim 1, wherein the step of providing a series of selective radio frequency pulses includes providing at least a third selective radio frequency pulse for each of the pairs of radio frequency pulses, wherein a plane defined by each of the third selective radio frequency pulses intersects one of the planes defined by one of the pairs at an intersection that defines a further imaging volume, wherein the further imaging volumes defined by the third selective radio frequency pulses and the pairs are part of a second image surface passing through the sample and having a spatial orientation that differs from the spatial orientation of the planes defined by the pairs and the planes defined by the third pulses.

10. The imaging method of claim 9, wherein the step of acquiring includes steps of providing magnetic dephasing and rephasing gradients to separate the nuclear magnetic resonance echo signals resulting from the intersections from the nuclear magnetic resonance echo signals resulting from the further intersections.

11. The imaging method of claim 10, wherein the steps of providing a dephasing and rephasing gradients and the step of providing magnetic diffusion gradients in the sample respectively provide magnetic dephasing and rephasing gradients and a magnetic diffusion gradient that are parallel for the volume defined for each pair and the volume defined for the third selective radio frequency pulse and that pair.

12. The imaging method of claim 9 wherein the step of acquiring employs an echo-volumar or echo-planar sequence.

13. The imaging method of claim 9 wherein the pulses in each of the pairs are multiple-frequency pulses.

14. The imaging method of claim 1 wherein the step of providing magnetic diffusion gradients in the sample provides differing diffusion gradients for successively defined imaging volumes.

15. The imaging method of claim 1, wherein the step of providing a series of selective radio frequency pulses includes providing a further series of selective radio frequency pulses that includes a series of further pairs of radio frequency pulses, which further pairs each define a pair of further planes that intersect at an intersection that are part of a further imaging volume, wherein the further imaging volumes defined by the further pairs define a second image surface passing through the sample adjacent the first image surface and having a spatial orientation that differs from the spatial orientation of the planes defined by the further pairs.

16. The imaging method of claim 15, wherein the imaging volumes that are part of the first surface are all defined before the imaging volumes that are part of the second surface are defined.

17. The imaging method of claim 15, wherein individual ones of the imaging volumes overlap individual ones of the second set of volumes.

18. The imaging method of claim 1, further including the step of employing the first image to evaluate tissue ischemia.

19. The imaging method of claim 1, further including cardiac gating to obtain diffusion images of the heart.

20. The imaging method of claim 1, further including the step of acquiring the volumes during breathhold.

21. The imaging method of claim 1, further including the step of employing the image to monitor temperature.

22. The imaging method of claim 1, wherein the acute angle between the planes defined by the pulses in each pair is less than about fifteen degrees, and wherein the step of acquiring employs an echo-planar sequence to obtain image data for a plurality of image surfaces including the first image surface.

23. The imaging method of claim 22, further including the step of providing a series of saturation pulses to saturate signals from unwanted volumes within the sample.

24. The imaging method of claim 1, wherein diffusion values measured within the imaging volumes are enhanced such that the image generated in the step of processing employs a higher b-factor than a b-factor resulting from the step of providing magnetic diffusion gradients.

25. The imaging method of claim 1, wherein the step of providing a series of selective radio frequency pulses includes providing at least a third selective radio frequency pulse for each of the pairs of radio frequency pulses, wherein a plane defined by each of the third selective radio frequency pulses intersects with the volume defined by one of the pairs of pulses, such that the echoes aquired in the step of aquiring are stimulated echoes.

26. The imaging method of claim 1 wherein the step of providing a series of selective radio frequency selective pulses defines the imaging volumes in a radial pattern.

27. The method of claim 1, wherein the acute angles between the image surface and each of the planes defined by the pairs are equal.

28. The method of claim 1, wherein the acute angles between the image surface and each of the planes defined by the pairs are in the range of 65 degrees to 75 degrees.

29. The imaging method of claim 1 wherein the image surface is a closed or overlapping surface.

30. A magnetic resonance imaging method comprising:

providing a series of selective radio frequency pulses that includes a series of pairs of radio frequency pulses, which pairs each define a pair of planes that intersect at an intersection that defines an imaging volume, wherein the imaging volumes defined by the pairs are distinctly positioned and are part of a first image surface passing through the sample and having a spatial orientation that differs from the spatial orientation of the planes defined by the pairs, and wherein the step of providing a series of selective pulses alternately swaps the orientation of first and second successively defined pairs of the selective radio frequency pulses, such that the plane defined by the first pulse in time in the first of the successive pairs does not coincide within the sample with the plane defined by the last pulse in time in the second of the successive pairs,

acquiring a series of nuclear magnetic resonance echo signals resulting from the intersection of the planes in the step of providing a series of selective pulses, and

processing the nuclear magnetic resonance echo signals acquired in the step of acquiring to obtain an image that includes lines corresponding to the imaging volumes defined by the pairs.

31. The magnetic resonance imaging method of claim 30 wherein the step of acquiring is performed without any crusher gradients.

32. A magnetic resonance imaging method comprising:

providing a series of selective radio frequency pulses that includes a series of pairs of radio frequency pulses, each of the pairs defining a pair of planes that intersect at an intersection that defines an imaging volume, wherein the imaging volumes defined by the pairs are distinctly positioned and are part of a first image surface passing through the sample, and wherein the step of providing a series of selective radio frequency pulses is performed in an interleaved manner to successively define the imaging volumes with different sensitivities to a parameter,

acquiring a series of nuclear magnetic resonance echo signals resulting from the intersection of the planes in the step of providing a series of selective pulses, and

processing the nuclear magnetic resonance echo signals acquired in the step of acquiring to obtain at least one image that includes lines corresponding to the imaging volumes defined by the pairs.

33. The magnetic resonance imaging method of claim 32 further including the step of providing magnetic diffusion gradients in the sample and associated with at least a subset of the imaging volumes, wherein the parameter relates to the magnetic diffusion gradients, and wherein the step of providing magnetic diffusion gradients in the sample provides differing diffusion gradients for successive ones of the imaging volumes.

34. The magnetic resonance imaging method of claim 33 wherein the differing magnetic diffusion gradients differ in their magnitude.

35. The magnetic resonance imaging method of claim 33 wherein the differing magnetic diffusion gradients differ in their directions.

36. The magnetic resonance imaging method of claim 33 wherein the differing diffusion gradients have the same directions, but opposite polarities.

37. The magnetic resonance imaging method of claim 33 wherein the step of providing magnetic diffusion gradients repeatedly provides four differing diffusion gradients including a low magnitude diffusion gradient and including three orthogonally oriented high magnitude diffusion gradients.

38. The magnetic resonance imaging method of claim 33 wherein the step of providing magnetic diffusion gradients repeatedly provides six differing diffusion gradients including three orthogonally oriented low magnitude diffusion gradients and three orthogonally oriented high magnitude diffusion gradients.

39. A magnetic resonance imaging method comprising:

providing a series of selective radio frequency pulses that includes a series of pairs including a selective two-dimensional radio frequency and another selective radio frequency pulse, wherein the two dimensional radio frequency pulse in each pair defines a pulse-defined volume and the other radio frequency pulse in that pair defines a plane that intersects the pulse-defined volume at an intersection that defines an imaging volume, wherein the imaging volumes defined by the pairs are distinctly positioned and form part of a plurality of image surfaces passing through the sample,

providing magnetic diffusion gradients in the sample and associated with at least a subset of the imaging volumes,

acquiring a series of nuclear magnetic resonance echo signals resulting from the intersection of the pulse-defined volumes and the planes in the step of providing a series of selective pulses, wherein at least a subset of the nuclear magnetic resonance echo signals are responsive to the influence of the diffusion gradients, and

processing the nuclear magnetic resonance echo signals acquired in the step of acquiring to obtain a plurality of images that each include lines corresponding to the imaging volumes in one of the imaging surfaces.

40. The magnetic resonance imaging method of claim 39 wherein the step of providing a series of selective pulses provides the selective two-dimensional radio frequency pulses as two-dimensional spiral pulses.

41. The magnetic resonance imaging method of claim 39 wherein the step of providing a series of selective pulses alternates between defining imaging volumes in different individual ones of the plurality of image surfaces.

42. The magnetic resonance imaging method of claim 39 wherein the selective two-dimensional radio frequency pulses are Fourier-spliced pencil pulses and the pulse-defined volumes are strips that extend across more than one of the plurality of image surfaces, and wherein the step of acquiring employs an echo-planar sequence to obtain the image data for the plurality of image surfaces.

43. The magnetic resonance imaging method of claim 39 wherein the step of providing selective radio frequency pulses includes providing a series of further pairs each including a selective two-dimensional radio frequency and another radio frequency pulses, wherein the two dimensional radio frequency pulse in each further pair defines a further pulse-defined volume and the other radio frequency pulse in that further pair defines a plane that intersects the further pulse-defined volume at an intersection that defines a further imaging volume, wherein the further imaging volumes defined by the pairs are distinctly positioned and define a plurality of image surfaces passing through the sample, and wherein the step of processing the nuclear magnetic resonance echo signals acquired in the step of acquiring further includes obtaining further images that each include lines corresponding to the further imaging volumes in one of the further imaging surfaces.

44. A magnetic resonance imaging apparatus, comprising:

means for providing a series of selective radio frequency pulses that includes a series of pairs of radio frequency pulses, which pairs each define a pair of planes that intersect at an intersection that defines an imaging volume, wherein the imaging volumes defined by the pairs are distinctly positioned and are part of a first image surface passing through the sample and having a spatial orientation that differs from the spatial orientation of the planes defined by the pairs,

means for providing magnetic diffusion gradients in the sample and associated with at least a subset of the imaging volumes,

means for acquiring a series of nuclear magnetic resonance echo signals resulting from the intersection of the planes in the step of providing a series of selective pulses, wherein at least a subset of the nuclear magnetic resonance echo signals are responsive to the influence of the diffusion gradients, and

means for processing the nuclear magnetic resonance echo signals acquired in the step of acquiring to obtain an image that includes lines corresponding to the imaging volumes defined by the pairs.

45. A magnetic resonance imaging method, comprising:

simultaneously exciting orthogonal gradient coils to a first plurality of extents during a magnetic resonance imaging sequence to sensitize the sequence to diffusion in a first direction,

simultaneously exciting the orthogonal gradient coils to a second plurality of extents during a second magnetic resonance imaging sequence to sensitize the sequence to diffusion in a second direction, the first direction being orthogonal to the second direction, and

simultaneously exciting the orthogonal gradient coils to a third plurality of extents during a third magnetic resonance imaging sequence to sensitize the sequence to diffusion in a third direction, the first, second, and third directions being orthogonal to each other, wherein there are first, second, and third ones of the gradient coils, and wherein each of the steps of simultaneously exciting includes exciting each of the first, second and third of the three orthogonal gradient coils.

46. The magnetic resonance imaging method of claim 45, wherein the first direction is defined by a plurality of extents including respective relative amplitudes of (-1, 1, -1/2) for the first, second, and third coils, wherein the second direction is defined by a plurality of extents including respective relative amplitudes of (1, 1/2, -1) for the first, second, and third coils, and wherein the third direction is defined by a plurality of extents including respective relative amplitudes of (1/21, 1) for the first, second, and third coils.