Atrial rate determination and atrial tachycardia detection in a dual-chamber implantable pacemaker

• US 5,788,717 A
• Filed: 07/11/1995
• Issued: 08/04/1998
• Est. Priority Date: 07/11/1995
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories Incorporated)
• Inventors: Florio, Joseph J., Sloman, Laurence S., Mann, Brian M.
• Primary Examiner(s): Kamm, William G.
• Assistant Examiner(s): Jastrzab, Jeffrey R.
• Application Number:
  US08/500,730
• Time in Patent Office: 1,120 Days
• Field of Search: 607/9, 607/14, 607/17, 128/705, 128/706, 128/702
• US Class Current: 607/14
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585

Abstract

An implantable pacemaker accurately senses the regular atrial rhythm even though some portions of the atrial rhythm, e.g., every other P-wave, may potentially be masked or hidden within the ventricular absolute refractory period. Such sensing includes unmasking or uncovering any hidden P-waves, thereby allowing an accurate atrial rate to be determined. The hidden P-waves are uncovered by: changing the PV delay, not tracking a sensed P-wave, or comparing the incoming morphology of the atrial channel signal to a prior stored baseline morphology signal. The accurate atrial rate, once determined, allows the presence of an atrial tachycardia to be reliably confirmed, thereby enabling appropriate atrial anti-tachycardia pacing (ATP) procedures to be invoked, or mode switching from an atrial synchronous mode of operation, e.g., DDD, to a non-atrial synchronous mode, e.g., VVIR.

Claims

1. A method of determining the atrial rate of a patient in a dual-chamber implantable pacemaker, the pacemaker including:

sensing means for sensing P-waves;

pulse generation means for generating V-pulses;

timing means for defining a PV delay that defines a time interval allowed by the pacemaker between a sensed P-wave and a generated V-pulse, a basic pacing interval that defines a pacing rate, and an absolute refractory period following generation of a V-pulse during which P-waves are not sensed;

the method comprising;

(a) sensing a series of consecutive P-waves to determine an atrial rate;

(b) determining if the atrial rate is within an atrial rate zone where P-waves may be hidden within the absolute refractory period;

(c) if hidden P-waves may exist, examining that portion of the basic pacing interval corresponding to the absolute refractory period to determine if a hidden P-wave lies therewithin; and

(d) if a hidden P-wave is uncovered within the absolute refractory period, including such hidden P-wave within the series of consecutive P-waves sensed in step (a) to redetermine the atrial rate;

whereby the atrial rate is determined based on the inclusion of such hidden P-wave.

2. The method of claim 1, wherein step (c) comprises time-shifting the refractory period within the basic pacing interval.

3. The method of claim 2, wherein time-shifting the refractory period comprises shortening the PV delay.

4. The method of claim 3, further comprising incrementally shortening the PV delay in increments that prevent a V-to-V interval of the pacemaker from becoming less than a prescribed limit.

5. The method of claim 4, wherein the prescribed limit to which the V-to-V interval is limited is a maximum track rate (MTR) interval less k milliseconds.

6. The method of claim 5, wherein k comprises 10 to 50 milliseconds.

7. The method of claim 4, wherein the PV delay is incrementally shortened until a minimum PV delay is reached.

8. The method of claim 4, wherein the PV delay is incrementally shortened until a P-to-P interval is measured corresponding to a P-to-P rate that is faster than a predicted rate of hidden P-waves.

9. The method of claim 3, wherein time-shifting the refractory period comprises lengthening the PV delay.

10. The method of claim 1, wherein step (c) comprises ceasing to track a sensed P-wave, which sensed P-wave becomes a non-tracked P-wave, and not generating a V-pulse following the non-tracked P-wave, whereby no absolute refractory period is generated, the absolute refractory period thereby being removed from the basic pacing interval, thereby uncovering any P-waves that occur during the time period of the basic pacing interval as the absolute refractory period would have occurred had a V-pulse been generated.

11. The method of claim 10, further including generating an A-pulse y milliseconds after the non-tracked P-wave if no hidden P-wave is uncovered following the non-tracked P-wave, where y is a predetermined value.

12. The method of claim 11, where the value of y is at least 300 milliseconds and less than 500 milliseconds.

13. The method of claim 10, further including:

measuring the interval between the non-tracked P-wave and an uncovered P-wave, if present, as a fast P-to-P interval;

measuring the interval between two of the series of consecutive P-waves sensed in step (a) as a sensed P-to-P interval;

comparing the sensed P-to-P interval to the fast P-to-P interval to see if the sensed P-to-P interval is about twice as long as the fast P-to-P interval; and

if so,

determining the atrial rate based on the fast P-to-P interval.

14. The method of claim 13, further including switching an operating mode of the pacemaker from an atrial synchronous mode to a non-atrial synchronous mode if the atrial rate is faster than a preset atrial tachycardia detection rate (ATDR).

15. The method of claim 14, further including confirming the atrial rate, and if confirmed, performing atrial tachycardia pacing (ATP) in accordance with a predefined pacing pattern.

16. The method of claim 10 wherein, if a first P-wave is uncovered, the following additional steps are included:

measuring the interval between the non-tracked P-wave and the uncovered first P-wave as a first fast P-to-P interval,

tracking the uncovered first P-wave by generating a V-pulse one PV delay thereafter;

not tracking the next sensed P-wave so as to uncover a second P-wave, p1 measuring the interval between the most recent non-tracked P-wave and the uncovered second P-wave as a second fast P-to-P interval, and

determining the atrial rate based on at least the first and second fast P-to-P intervals.

17. The method of claim 16, further comprising:

tracking an nth uncovered P-wave by generating a V-pulse one PV delay thereafter, where n is an integer greater than one;

not tracking the next sensed P-wave so as to uncover an (n+1)th P-wave;

measuring the interval between the nth non-tracked P-wave and the uncovered (n+1)th P-wave as an (n+1)th fast P-to-P interval; and

further determining the atrial rate based on the (n+1)th fast P-to-P interval.

18. The method of claim 1, wherein the implantable pacemaker includes means for operating in either an atrial synchronous mode or a non-atrial synchronous mode, and wherein the method further includes:

(e) determining if the atrial rate exceeds a preset atrial tachycardia detection rate (ATDR), and if so, automatically switching the mode of operation of the pacemaker from an atrial synchronous mode to a non-atrial synchronous mode.

19. The method of claim 1, wherein the implantable pacemaker includes means for applying an antitachycardia pacing (ATP) procedure to break an atrial tachycardia, and wherein the method further includes:

(e) determining if the atrial rate exceeds a preset atrial tachycardia detection rate (ATDR), and if so, automatically invoking the ATP procedure.

20. The method of claim 1, wherein the implantable pacemaker also includes means for performing atrial defibrillation shock therapy, and wherein the method further comprises:

(e) determining if the atrial rate exceeds a preset atrial tachycardia detection rate (ATDR), and if so, applying the atrial defibrillation shock therapy.

21. The method of claim 1, wherein step (b) is carried out on a sampled basis.

22. The method of claim 21, wherein step (b) is initially carried out every n cardiac cycles.

23. The method of claim 21, further including sampling for hidden P-waves every m cardiac cycles in the event a hidden P-wave is not uncovered, where m is much greater than n.

24. The method of claim 23, wherein n is at least 8, and m is at least 100.

25. The method of claim 1, wherein the pacemaker further includes means for applying an antitachycardia pacing (ATP) therapy, and wherein the method further includes analyzing the atrial rate determined in step (d) to ascertain whether the atrial rate indicates the need to apply ATP therapy, and if so, applying such ATP therapy.

26. The method of claim 1, further including giving preference to any uncovered P-waves as the atrial rate is determined in step (d).

27. The method of claim 1, wherein step (c) comprises storing a baseline morphology of an intracardiac electrogram (IEGM) signal for that portion of the basic pacing interval corresponding to the absolute refractory period, and thereafter measuring a morphology of the IEGM signal to obtain a measured morphology, and comparing the measured morphology to the baseline morphology to determine if a hidden P-wave is present within the measured morphology.

28. The method of claim 27, wherein the step of comparing the measured morphology to the baseline morphology comprises subtracting the baseline morphology from the measured morphology.

29. The method of claim 1, wherein step (c) further includes sensing if atrial activity is present and uncovering a hidden P-wave only when sensed atrial activity is present in order to confirm that the uncovered hidden P-wave is a true P-wave and not a far-field R-wave.

30. A method of uncovering hidden P-waves that occur during the absolute refractory period following a ventricular stimulus of a dual-chamber implantable pacemaker, the pacemaker including:

sensing means for sensing P-waves;

pulse generation means for generating V-pulses;

timing means for defining a PV delay that defines a time interval allowed by the pacemaker between a sensed P-wave and a generated V-pulse, a basic pacing interval that defines a pacing rate, and an absolute refractory period following generation of a V-pulse during which P-wave sensing is not reliable;

the method comprising;

moving the absolute refractory period away from that portion of the basic pacing interval wherein hidden P-waves may lie; and

sensing whether any P-waves occur within that portion of the cardiac cycle from which the absolute refractory period has been moved, and if so, identifying such sensed P-waves as hidden P-waves.

31. The method of claim 30, wherein the step of moving the absolute refractory period comprises time shifting the absolute refractory period within the cardiac cycle by changing the duration of the PV delay.

32. The method of claim 31, wherein the step of changing the duration of the PV delay comprises shortening the PV delay.

33. The method of claim 32, wherein the step of shortening the duration of the PV delay comprises incrementally shortening the PV delay over several cardiac cycles so as to maintain a minimum V-to-V interval.

34. The method of claim 31, wherein the step of changing the duration of the PV delay comprises lengthening the PV delay.

35. The method of claim 30, wherein the step of moving the absolute refractory period comprises:

counting and tracking P-waves for n-1 cardiac cycles, where n is a prescribed number;

not tracking a P-wave during the nth cardiac cycle, whereby no PV delay is generated in the nth cardiac cycle, and no V-pulse is generated in the nth cardiac cycle, thereby moving the absolute refractory period from the nth cardiac cycle.

36. A method of determining the atrial rate of a patient having a dual-chamber pacemaker, the pacemaker including:

sensing means for sensing P-waves;

pulse generation means for generating V-pulses;

timing means for defining a basic pacing interval that defines a pacing rate and a maximum tracking rate (MTR) interval (MTRI) that limits the rate at which V-pulses are generated;

the method comprising;

determining if V-pulses are generated at a rate that is limited by the MTR, and if so

sensing P-waves that occur during the MTRI and classifying such P-waves as non-tracked P-waves,

sensing P-waves that occur outside the MTRI and classifying such P-waves as tracked P-waves, and

determining the atrial rate as a function of a P-to-P interval separating the consecutive sensed P-waves, whether such consecutive P-waves are non-tracked or tracked;

whereby the consecutive sensed P-waves define the determined atrial rate.

37. The method, as set forth in claim 36, wherein the pacemaker further includes non-tracked time intervals during which P-waves are not tracked, and wherein the method further comprises using P-waves sensed during such non-tracked time intervals to help determine the atrial rate.

38. A method for determining the presence of an atrial tachycardia in a patient having a dual-chamber pacemaker, the pacemaker comprising:

means for defining an atrial tachycardia detection rate (ATDR);

sensing means for sensing P-waves;

pulse generation means for generating a ventricular stimulation pulse (V-pulse) a prescribed time delay following a sensed P-wave; and

timing means for defining and generating a fixed, recurring, free-running atrial lock interval (ALI*) that is independent from any sensed cardiac events, the ALI* thus comprising a sequence of recurring fixed periods of length ALI*, the method comprising;

determining in more than one V-pulse would be generated in any given ALI* period, and if so,

inhibiting all but the first V-pulse in any given ALI* period,

measuring a P-to-P interval (PPI) for each inhibited V-pulse as the time interval between a first sensed P-wave following which the inhibited V-pulse would have been generated and a second sensed P-wave immediately following the first sensed P-wave,

determining if the PPI for i consecutive inhibited V-pulses corresponds to an atrial rate greater than the ATDR, where i is an integer greater than one, and if so

declaring an atrial tachycardia condition to be present.

39. The method, as set forth in claim 38, wherein the integer i comprises at least three.

40. A dual-chamber implantable pacemaker that detects atrial rate based on sensed P-waves, including sensed P-waves that are potentially hidden within an absolute refractory period, comprising:

sensing means for sensing a series of consecutive P-waves;

pulse generation means for generating V-pulses;

timing means for defining a PV delay that defines a time interval allowed by the pacemaker between a sensed P-wave and a generated V-pulse, a basic pacing interval that defines a pacing rate, and an absolute refractory period following generation of a V-pulse during which P-waves are not sensed;

control means for examining that portion of the basic pacing interval corresponding to the absolute refractory period to uncover any hidden P-waves that lie therewithin; and

rate-determining means for determining a true atrial rate based on all sensed P-waves, including any uncovered hidden P-waves.

41. The implantable pacemaker, as set forth in claim 40, wherein the control means comprises means for controlling the timing means so that the duration of the PV delay is systematically varied to time shift the occurrence of the absolute refractory period within a given pacing cycle.

42. The implantable pacemaker, as set forth in claim 40, wherein the control means comprises means for controlling the timing means so that the PV delay is not generated for certain P-waves, whereby such certain P-waves are not tracked, and no V-pulse is generated a PV delay thereafter.

43. A mode-switching pacemaker that automatically switches modes based on an atrial rate sensed by the pacemaker comprising:

sensing means for sensing a series of consecutive P-waves;

pulse generation means for generating V-pulses;

timing means for defining a PV delay that defines a time interval allowed by the pacemaker between a sensed P-wave and a generated V-pulse, a basic pacing interval that defines a pacing rate, and an absolute refractory period following generation of a V-pulse during which P-waves are not sensed;

control means for operating the pacemaker in an atrial synchronous mode and for examining that portion of the basic pacing interval corresponding to the absolute refractory period to uncover any hidden P-waves that lie therewithin;

rate-determining means for determining a true atrial rate based on all sensed P-waves, including any uncovered hidden P-waves; and

mode switching means for switching the mode of the pacemaker to a non-atrial synchronous mode in the event the atrial rate determined by the rate-determining means exceeds a preset atrial tachycardia detection rate (ATDR).

44. The mode switching pacemaker, as set forth in claim 43, wherein the rate-determining means comprises means for determining a true atrial rate based primarily on non-tracked sensed P-waves, a non-tracked sensed P-wave comprising a P-wave that is not followed by the PV delay.