Drug delivery device and method for employing the same
First Claim
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1. A drug delivery device comprising a single phase matrix solution of a negatively-charged water-soluble polymer and a positively-charged water-soluble polymer, wherein said matrix solution has dispersed therein a pharmaceutically active ingredient which is different from said negatively-charged water-soluble polymer and said positively-charged water-soluble polymer.
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Abstract
The present invention relates a drug delivery device which comprises a single phase matrix of two oppositely charged polymers (one positive and one negative), which releases a drug by combined mechanisms employing hindered diffusion, swelling and erosion. The present invention also relates to a method for employing these devices.
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29 Claims
- 1. A drug delivery device comprising a single phase matrix solution of a negatively-charged water-soluble polymer and a positively-charged water-soluble polymer, wherein said matrix solution has dispersed therein a pharmaceutically active ingredient which is different from said negatively-charged water-soluble polymer and said positively-charged water-soluble polymer.
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14. A method for sustaining release of a pharmaceutically active ingredient in a subject, comprising:
administering to a subject a drug delivery device comprising a single phase matrix solution of a negatively-charged water-soluble polymer and a positively-charged water-soluble polymer, wherein said matrix solution has dispersed therein a pharmaceutically active ingredient which is different from said negatively-charged water-soluble polymer and said positively-charged water-soluble polymer. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 29)
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