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Biodegradable coating with inhibitory properties for application to biocompatible materials

  • US 5,788,979 A
  • Filed: 02/10/1997
  • Issued: 08/04/1998
  • Est. Priority Date: 07/22/1994
  • Status: Expired due to Term
First Claim
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1. A method for coating a biomaterial to be placed in contact with a patient'"'"'s blood to inhibit blood coagulation on the biomaterial that would otherwise result from such contact, comprising the steps of:

  • preparing a biodegradable material in a liquid state which is compatible with the blood and tissue of the human body;

    incorporating at least an anti-coagulant drug into the liquid state of the biodegradable material to form a liquid coating material; and

    adhesively applying the liquid coating material to a surface of the biomaterial in a substantially continuous overlying layer having a formulation, pattern and thickness selected according to the period of time over which the coating material is to perform its anti-coagulant action, and thereafter drying the coating material to a layer thickness less than about 100 microns for continuous disintegration thereof as a function of time when said layer is in contact with flowing blood.

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