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Methods of synthesizing diverse collections of oligomers

  • US 5,789,162 A
  • Filed: 06/07/1995
  • Issued: 08/04/1998
  • Est. Priority Date: 09/18/1991
  • Status: Expired due to Fees
First Claim
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1. A method of recording each step in a synthesis of a compound, said compound being produced by step-by-step assembly of building blocks, said method comprising the steps of:

  • (a) coupling to a solid support a first building block and a first identifier tag under conditions compatible with immobilization of the first building block and the first identifier tag, wherein said first identifier tag identifies the first building block and wherein said first identifier tag is a nucleotide or oligonucleotide;

    (b) repeating step (a) until the desired compound is prepared on said solid support; and

    (c) sequencing the identifier tags that are present on said solid support to identify the corresponding building blocks coupled to said solid support.

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