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Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor

  • US 5,789,184 A
  • Filed: 06/05/1995
  • Issued: 08/04/1998
  • Est. Priority Date: 03/31/1993
  • Status: Expired due to Term
First Claim
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1. A yeast cell having a pheromone system, which cell comprises(a) a first heterologous gene encoding a heterologous surrogate of a yeast pheromone system protein, said surrogate being a kinase and performing in the pheromone system of the yeast cell a function naturally performed by the corresponding yeast pheromone system protein, and(b) a second heterologous gene encoding a heterologous peptide, wherein said heterologous peptide modulates the interaction of said surrogate with said pheromone system in the yeast cell, and said modulation is a selectable or screenable event.

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