Apparatus and method of bioelectrical impedance analysis of blood flow

• US 5,791,349 A
• Filed: 04/17/1996
• Issued: 08/11/1998
• Est. Priority Date: 04/17/1996
• Status: Expired due to Term

• Current Assignee: Ecom Med Inc.
• Original Assignee: Urohealth, Inc. (California) (Imagyn Medical Technologies, Inc.)
• Inventors: Shmulewitz, Ascher
• Primary Examiner(s): Millin, V.
• Assistant Examiner(s): Wieland, Robert N.
• Application Number:
  US08/634,758
• Time in Patent Office: 846 Days
• Field of Search: 128/734, 128/741, 128/774, 128/795, 128/796, 128/639, 128/644, 128/693, 128/692, 128/691, 128/642, 128/713
• US Class Current: 600/547
• CPC Class Codes: A61B 5/0295 using plethysmography, i.e. measuring the variations in the volume of a body part as modified by the circulation of blood therethrough, e.g. impedance plethysmography
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0538 invasively, e.g. using a catheter

Abstract

Apparatus and methods are provided for monitoring cardiac output using bioelectrical impedance techniques in which one or more interior electrodes are placed in the trachea in the vicinity of the ascending aorta, and one or more exterior electrodes are disposed near the suprasternal notch, so that the resulting bioelectrical impedance measurements reflect voltage changes induced primarily by blood flow dynamics, rather than respiratory or non-cardiac related physiological effects. Apparatus and methods are also provided so that the measured cardiac output may be used to control administration of intravenous fluids to a patient or to optimize heart rate for those patients having pacemakers.

Claims

1. Apparatus for determining the cardiac output of a patient, the apparatus comprising:

a first electrode adapted to be disposed within the trachea of the patient;

a second electrode adapted to be disposed on the exterior of the thorax of the patient;

a bioelectrical impedance recorder providing an output, the bioelectrical impedance recorder coupled to the first and second electrodes to pass a current therebetween; and

means for processing the output of the bioelectrical impedance recorder to compute a metric corresponding to the patient'"'"'s cardiac output.

2. Apparatus as defined in claim 1 further comprising an endotracheal tube having a proximal end and a distal end, the first electrode being disposed upon the distal end.

3. The apparatus as defined in claim 2 further comprising a third electrode coupled to the bioelectrical impedance recorder and disposed upon the distal end.

4. Apparatus as defined in claim 1 wherein the second electrode is adapted to be disposed on the skin of the patient in the vicinity of the suprasternal notch.

5. The apparatus as defined in claim 4 further comprising a fourth electrode coupled to the bioelectrical impedance recorder and adapted to be disposed on the skin of the thorax in the vicinity of the suprasternal notch.

6. The apparatus as defined in claim 2 wherein the endotracheal tube further comprises an inflatable cuff.

7. The apparatus as defined in claim 6 wherein the first electrode is disposed upon the inflatable cuff.

8. The apparatus as defined in claim 6 wherein the endotracheal tube further comprises a lumen for inflating the inflatable cuff, and the inflatable cuff permits ventilation of the patient when inflated.

9. The apparatus as defined in claim 1 further comprising a fluid administration system for injecting a bolus of fluid into the vascular system of the patient, the fluid administration system coupled to the means for processing and responsive to the metric corresponding to the cardiac output.

10. The apparatus as defined in claim 1 further comprising a pacemaker controlling the heart rate of the patient, the pacemaker coupled to the means for processing and responsive to the metric corresponding to the cardiac output.

11. The apparatus as defined in claim 1 wherein the means for processing comprises a suitably programmed IBM-compatible computer.

12. The apparatus as defined in claim 11 wherein the means for processing further comprises circuitry for digitizing the output of the bioelectrical impedance recorder.

13. A method of measuring the cardiac output of a patient comprising steps of

positioning a first electrode within the trachea of the patient in the vicinity of the ascending aorta;

positioning a second electrode on the exterior of the thorax of the patient in the vicinity of the suprasternal notch;

applying a voltage between the first and second electrodes so that a current flows through the tissues of the patient between the first and second electrodes; and

detecting a voltage developed across the first and second electrodes caused by the current flowing in the tissues of the patient, the voltage varying in accordance with changes in the electrical bioimpedance of the tissues.

14. The method as defined in claim 13 wherein the first electrode is disposed on an endotracheal tube and the step of positioning the first electrode further comprises a step of inserting the endotracheal tube in the trachea of the patient through a nasal cavity of the patient.

15. The method as defined in claim 13 wherein the first electrode is disposed on an endotracheal tube and the step of positioning the first electrode further comprises a step of inserting the endotracheal tube in the trachea of the patient through the mouth of the patient.

16. The method as defined in claim 13 wherein the first electrode is disposed on an endotracheal tube and the step of positioning the first electrode further comprises a step of inserting the endotracheal tube in the trachea of the patient through a tracheotomy port.

17. The method as defined in claim 13 wherein the first electrode is disposed on an endotracheal tube having an inflatable cuff and the step of positioning the first electrode further comprises a step of inflating the inflatable cuff.

18. The method as defined in claim 13 wherein the steps of applying the voltage and detecting a voltage developed across the first and second electrodes are performed continuously.

19. The method as defined in claim 13 further comprising steps of:

providing a fluid administration system for injecting a bolus of fluid intravenously into the patient'"'"'s vascular system;

periodically actuating the fluid administration system on responsive to the detected voltage developed across the first and second electrodes.

20. The method as defined in claim 19 wherein the step of periodically actuating the fluid administration system is performed every 15 minutes only while the cardiac output is measured to be increasing.

21. The method as defined in claim 13 further comprising steps of:

providing a pacemaker electrically coupled to the heart of the patient to control heart rate; and

adjusting the heart rate responsive to voltage developed across the first and second electrodes to optimize cardiac output.

22. The method as defined in claim 21 wherein the step of adjusting the heart rate comprises a step of lowering the heart rate to obtain either a predetermined minimum heart rate or until the cardiac output is measured to be decreasing.

23. The method as defined in claim 22 wherein the step of lowering the heart rate comprises adjusting the heart rate downward by two beats per minute every 15 minutes.