Methods and compositions for inhibiting tissue adhesion
First Claim
1. A method for inhibiting the formation of adhesions between adjacent tissue surfaces, said method comprising:
- exposing a target region on at least one of the tissue surfaces;
positioning a preformed, biocompatible, resorbable solid layer of matrix material having a thickness of about 0.01 mm to 2 mm over the target region;
applying about 2 W to 100 W energy to the matrix material over a region for approximately 5 seconds to 120 seconds and in an amount sufficient to immobilize the matrix material layer over the target region; and
permitting the adjacent tissue surface to reassume their natural juxtaposition, wherein the immobilized layer of matrix material inhibits adhesions therebetween.
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Accused Products
Abstract
Tissue adhesions are inhibited by applying and immobilizing a solid preformed matrix material over a target region, such as a surgical site, in a first tissue surface. The matrix material may be any continuous solid material, such as a sheet or film. After applying the material to the target region, the material is immobilized by applying energy over at least a portion of the surface of the matrix material which causes the material to fuse to the underlying tissue. The matrix material is preferably bioabsorbable so that it is resorbed by the body over time. Suitable matrix materials include proteins, polysaccharrides, and synthetic polymers.
152 Citations
22 Claims
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1. A method for inhibiting the formation of adhesions between adjacent tissue surfaces, said method comprising:
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exposing a target region on at least one of the tissue surfaces; positioning a preformed, biocompatible, resorbable solid layer of matrix material having a thickness of about 0.01 mm to 2 mm over the target region; applying about 2 W to 100 W energy to the matrix material over a region for approximately 5 seconds to 120 seconds and in an amount sufficient to immobilize the matrix material layer over the target region; and permitting the adjacent tissue surface to reassume their natural juxtaposition, wherein the immobilized layer of matrix material inhibits adhesions therebetween. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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Specification