Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent

• US 5,792,056 A
• Filed: 12/27/1996
• Issued: 08/11/1998
• Est. Priority Date: 06/07/1993
• Status: Expired due to Term

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/777,347
• Time in Patent Office: 592 Days
• Field of Search: 600/410, 600/420, 600/419, 600/431, 424/9.36, 424/9.3, 324/307, 324/309
• US Class Current: 600/420
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Claims

1. An apparatus for imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance contrast agent, comprising,

detecting means for detecting an arrival of the administered magnetic resonance contrast agent in a region of interest;

image acquisition signal generator for generating an image acquisition signal; and

imaging means, coupled to the detecting means and image acquisition signal generator, for collecting image data which is representative of at least a portion of a center of k-space in response to the image acquisition signal.

2. The apparatus of claim 1 wherein the imaging means collects image data which is representative of the center of k-space substantially at a beginning of a 3D imaging sequence.

3. The apparatus of claim 1 wherein the imaging means includes means for collecting image data which is representative of a substantial portion of a center of k-space when a concentration of magnetic resonance contrast agent in the artery is substantially greater than a concentration of contrast agent in veins adjacent to the artery.

4. The apparatus of claim 1 wherein the imaging means includes means for collecting image data which is representative of at least a portion of a center of k-space while a concentration of the contrast agent in the artery is substantially a maximum relative to a concentration of the contrast agent in veins adjacent to the artery.

5. The apparatus of claim 4 further including administration means for rapidly administering the contrast agent to the patient.

6. The apparatus of claim 5 wherein the administration means administers the contrast agent at a rate greater than about 0.05 millimoles/sec and wherein the region of interest includes at least a portion of the artery and wherein the artery is the aorta.

7. The apparatus of claim 5 wherein the administration means administers the contrast agent at a rate greater than about 1 cc/sec and wherein the region of interest includes at least a portion of the artery and wherein the artery is the aorta.

8. The apparatus of claim 1 wherein the imaging means further includes means for collecting image data which is representative of a portion of the center of k-space while a concentration of contrast agent in the artery is substantially greater than a concentration of contrast in veins adjacent to the artery.

9. The apparatus of claim 1 wherein the image acquisition signal generator generates the image acquisition signal in response to an arrival of the magnetic resonance contrast agent in the region of interest.

10. The apparatus of claim 1 wherein the image acquisition signal generator further includes an operator interface for generating the image acquisition signal in response to an operator input.

11. The apparatus of claim 1 wherein the imaging means further includes means for collecting a first image data set including image data which is representative of at least a portion of a center of k-space before administering a magnetic resonance contrast agent and for collecting a second image data set including image data which is representative of at least a portion of a center of k-space after the detecting means detects the arrival of the magnetic resonance contrast agent in the region of interest.

12. The apparatus of claim 11 wherein the imaging means further includes means for constructing an image of the artery by subtracting at least two images selected from a set of images comprising images of the first image data set and images of the second image data set.

13. An apparatus for imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance imaging contrast agent, comprising,

monitoring means for monitoring a region of interest to sense an arrival of the administered magnetic resonance contrast agent in the region of interest;

and

imaging means for collecting image data which is representative of at least a portion of a center of k-space while the concentration of contrast agent in the artery is substantially a maximum relative to a concentration of contrast agent in veins adjacent the artery.

14. The apparatus of claim 13 wherein the imaging means collects the image data which is representative of the center of k-space substantially at a beginning of a 3D imaging sequence.

15. The apparatus of claim 14 wherein the imaging means collects image data which is representative of a periphery of k-space after collecting image data which is representative of the center of k-space.

16. The apparatus of claim 13 further including image acquisition signal generator means, coupled to the imaging means, for generating an image acquisition signal in response to the monitoring means sensing the arrival of the contrast agent in the region of interest and wherein the imaging means collects image data which is representative of at least a portion of the center of k-space after the image acquisition signal generator means generates the image acquisition signal.

17. The apparatus of claim 16 wherein the imaging means includes means for collecting image data which is representative of a substantial portion of a center of k-space when a concentration of magnetic resonance contrast agent in the artery is substantially greater than a concentration of contrast agent in veins adjacent to the artery.

18. The apparatus of claim 13 wherein the imaging means further includes means for collecting a first image data set including image data which is representative of at least a portion of a center of k-space before administering a magnetic resonance contrast agent and for collecting a second image data set including image data which is representative of at least a portion of a center of k-space after the monitoring means senses the arrival of the magnetic resonance contrast agent in the region of interest.

19. The apparatus of claim 18 wherein the imaging means further includes means for constructing an image of the artery by subtracting at least two images selected from a set of images comprising images of the first image data set and images of the second image data set.

20. The apparatus of claim 13 further including image acquisition signal generator means for generating an image acquisition signal after the monitoring means senses the arrival of the magnetic resonance contrast agent in the region of interest and wherein the imaging means collects image data which is representative of at least a portion of a center of k-space in response to the image acquisition signal.

21. The apparatus of claim 13 further including an operator interface for generating an image acquisition signal in response to an operator input and wherein the imaging means collects image data which is representative of at least a portion of a center of k-space in response to the image acquisition signal.

22. A method of imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance contrast agent, comprising,

monitoring a region of interest to detect an arrival of the administered magnetic resonance contrast agent in a region of interest;

and

imaging at least a portion of the artery including collecting image data which is representative of at least a portion of a center of k-space when a concentration of contrast agent in the artery is substantially greater than a concentration of contrast agent in veins adjacent to the artery.

23. The method of claim 22 wherein the step of imaging at least a portion of the artery further includes collecting image data which is representative of a portion of the center of k-space while the concentration in the artery is substantially a maximum relative to a concentration of contrast agent in veins adjacent to the artery.

24. The method of claim 22 further including the step of administering the magnetic resonance contrast agent to the patient in a bolus type injection and wherein the step of imaging at least a portion of the artery includes collecting image data of a 3D imaging sequence and the step of collecting image data which is representative of the center of k-space includes collecting the image data substantially at a beginning of the 3D imaging sequence.