Oxygen generating wound dressing
First Claim
1. An oxygen-generating wound dressing suitable for periodically increasing the oxygen supply to a wound, comprising:
- a) an oxygen permeable membrane; and
b) an oxygen supply reservoir proximate said oxygen permeable membrane and adapted to receive an aqueous solution containing a solute, said solute capable of renewably and non-sustainingly chemically generating oxygen, andc) a catalyst or enzyme contained within said wound dressing, said catalyst or enzyme capable of decomposing said solute to generate oxygen, said periodic increase in oxygen supply renewable indefinitely by addition of further aqueous solution.
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Abstract
The healing of surface wounds, including burns, is facilitated by increasing the wound oxygen tension through the application of an oxygen-generating wound dressing which renewably and non-sustainingly chemically generates oxygen. The wound dressing contains an oxygen permeable membrane and an oxygen supply solution reservoir adapted to receive an aqueous liquid capable of supplying oxygen through chemical reaction. Preferably, the aqueous liquid contains hydrogen peroxide and the reservoir contains an immobilized solid hydrogen peroxide decomposition catalyst such as manganese dioxide. The solid catalyst may be contained within a hydrogel, an open-celled polymeric foam, or a biosynthetic foam such as a collagen foam. The oxygen-generating wound dressing may be applied over an intermediate hydrogel occlusive wound covering such as an alginate.
221 Citations
20 Claims
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1. An oxygen-generating wound dressing suitable for periodically increasing the oxygen supply to a wound, comprising:
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a) an oxygen permeable membrane; and b) an oxygen supply reservoir proximate said oxygen permeable membrane and adapted to receive an aqueous solution containing a solute, said solute capable of renewably and non-sustainingly chemically generating oxygen, and c) a catalyst or enzyme contained within said wound dressing, said catalyst or enzyme capable of decomposing said solute to generate oxygen, said periodic increase in oxygen supply renewable indefinitely by addition of further aqueous solution. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method for renewably and non-sustainingly increasing the oxygen tension in surface wounds, comprising:
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a) applying over the surface of said wound an oxygen generating wound dressing comprising; i) an oxygen permeable membrane having a size adapted to substantially cover said wound; ii) a chemical oxygen supply reservoir abutting said oxygen permeable membrane on the side of said membrane most distant from said wound; b) supplying to said oxygen supply reservoir an oxygen supply solution containing a solute, said solute capable of chemically generating oxygen within said reservoir by catalytic decomposition, and c) a catalyst or enzyme contained within said wound dressing, said catalyst or enzyme capable of decomposing said solute to generate oxygen. - View Dependent Claims (17, 18, 19, 20)
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Specification