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Systems and methods for delivering therapeutic agents to selected sites in a subject

  • US 5,792,110 A
  • Filed: 06/26/1996
  • Issued: 08/11/1998
  • Est. Priority Date: 06/26/1996
  • Status: Expired due to Term
First Claim
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1. A system for delivering a therapeutic agent to a selected site in a subject, comprising:

  • a rigid guide cannula for penetrating the subject to a site adjacent to the selected site, the guide cannula having an axial bore extending therethrough within which a delivery cannula can be disposed, an open proximal end, an opening at a distal portion thereof, a distal end which is a blunt end, and a wall which is sufficiently rigid such that it is capable of deflecting, at a predetermined deflection angle relative to the midline of the guide cannula, a delivery cannula disposed therein as the delivery cannula is extended through the opening at the distal portion of the guide cannula; and

    a delivery cannula disposable within the guide cannula for delivering the therapeutic agent to the selected site in the subject, the delivery cannula having an axial bore extending therethrough, a flexible distal end portion, and an outer diameter which is less than the inner diameter of the guide cannula, wherein the delivery cannula, when extended through the opening at the distal portion of the guide cannula, is adapted to be deflected by a wall of the guide cannula at a predetermined deflection angle relative to the midline of the guide cannula and along a new trajectory imposed by the deflection angle and thereafter maintaining the new trajectory in the subject without being diverted by forces imposed by structures within the subject.

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