Method and apparatus for treating neurodegenerative disorders by electrical brain stimulation

• US 5,792,186 A
• Filed: 04/30/1997
• Issued: 08/11/1998
• Est. Priority Date: 04/25/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Rise, Mark T.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): EVANISKO, GEORGE ROBERT
• Application Number:
  US08/847,654
• Time in Patent Office: 468 Days
• Field of Search: 607/2, 607/45, 607/46
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36067 Movement disorders, e.g. tremor or Parkinson disease stimulating motor muscle A61N1/36003
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36171 Frequency

Abstract

Techniques for stimulating the brain to reduce the effects of neurodegenerative disorders by an implantable signal generator and electrode. A sensor is used to detect the symptoms resulting from the disorder. A microprocessor algorithm analyzes the output from the sensor in order to regulate the stimulation delivered to the brain.

Claims

1. A system for treating a neurodegenerative disorder characterized by hyperexcitation of a portion of a brain comprising in combination:

an implantable signal generator for providing stimulation pulses;

an implantable electrode having a proximal end coupled to said signal generator and a stimulation portion adapted to stimulate a predetermined site in a brain;

a sensor for transmitting a signal related to the excitation of the portion of the brain exhibiting hyperexcitation; and

a microprocessor responsive to said sensor signal for regulating at least one parameter of said stimulation by said implantable electrode, said at least one parameter being selected from the group consisting of pulse width, pulse frequency, and pulse amplitude.

2. A system, as claimed in claim 1, wherein said sensor comprises a sensor of electrical activity.

3. A system, as claimed in claim 1, wherein said sensor comprises an electrochemical sensor.

4. A system, as claimed in claim 3, wherein said electrochemical sensor is responsive to the amount of glutamate present in the substantia nigra.

5. A method of treating a neurodegenerative disorder characterized by hyperexcitation comprising in combination:

implanting a signal generator in a body of a patient;

implanting at least one electrode to be in communication with at least one predetermined site in the brain of said body;

coupling said at least one electrode to said signal generator;

pulse stimulating said at least one predetermined site in said brain of said body using said at least one electrode;

implanting a sensor in said body for generating a sensor signal related to the extent of hyperexcitation exhibited by a portion of said brain; and

regulating at least one parameter of said step of stimulating in response to said sensor signal, said at least one parameter being selected from the group consisting of pulse width, pulse frequency, and pulse amplitude.

6. A method, as claimed in claim 5, wherein said neurodegenerative disorder is Parkinson'"'"'s disease and wherein said step of stimulating is performed to increase thalamic output.

7. A method, as claimed in claim 6, wherein said step of stimulating increases excitement of the thalamus or decreases inhibition of the thalamus.

8. A method, as claimed in claim 7, wherein said step of stimulating increases inhibition or decreases excitation of an internal segment of globus pallidus (GPi) or substantia nigra pars reticulata (SNr).

9. A method, as claimed in claim 7, wherein said step of stimulating increases excitation or decreases inhibition of an external segment of globus pallidus (Gpe).

10. A method, as claimed in claim 5, wherein said signal generator operates in a high frequency range of 50 to 2500 Hz and said at least one predetermined site in said brain of said body is selected from the group consisting of the internal segment of globus pallidus (Gpi), substantia nigra pars reticulata (SNr) and the neostriatum.

11. A method, as claimed in claim 5, wherein said signal generator operates in a low frequency range of 2 to 100 Hz and said at least one predetermined site in said brain of said body is selected from the group consisting of the ventrolateral thalamus (Thal), striatopallidal fiber pathway, neostriatum, external segment of globus pallidus (Gpe), and external segment of globus pallidus to subthalamic nucleus fiber pathway.

12. A method of treating a neurodegenerative disorder characterized by hyperexcitation comprising in combination:

implanting at least one electrode to be in communication with at least one predetermined site in the brain of said body;

coupling said at least one electrode to a signal generator;

pulse stimulating said at least one predetermined site in said brain of said body using said at least one electrode;

generating a sensor signal related to the extent of hyperexcitation exhibited by a portion of said brain; and

regulating at least one parameter of said step of stimulating in response to said sensor signal, said at least one parameter being selected from the group consisting of pulse width, pulse frequency, and pulse amplitude.

13. A method, as claimed in claim 12, wherein said neurodegenerative disorder is Parkinson'"'"'s disease and wherein said step of stimulating is performed to increase thalamic output.

14. A method, as claimed in claim 13, wherein said step of stimulating increases excitement of the thalamus or decreases inhibition of the thalamus.

15. A method, as claimed in claim 14, wherein said step of stimulating increases inhibition or decreases excitation of said internal segment of globus pallidus (GPi) or substantia nigra pars reticulata (SNr).

16. A method, as claimed in claim 14, wherein said step of stimulating increases excitation or decreases inhibition of said external segment of globus pallidus (Gpe).

17. A method, as claimed in claim 12, wherein said signal generator operates in a high frequency range of 50 to 2500 Hz and said at least one predetermined site in said brain of said body is selected from the group consisting of the internal segment of globus pallidus (Gpi), substantia nigra pars reticulata (SNr) and the neostriatum.

18. A method, as claimed in claim 12, wherein said signal generator operates in a low frequency range of 2 to 100 Hz and said at least one predetermined site in said brain of said body is selected from the group consisting of the ventrolateral thalamus (Thal), striatopallidal fiber pathway, neostriatum, external segment of globus pallidus (Gpe), and external segment of globus pallidus to subthalamic nucleus fiber pathway.