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Mutant diphtheria toxin conjugates

  • US 5,792,458 A
  • Filed: 10/17/1994
  • Issued: 08/11/1998
  • Est. Priority Date: 10/05/1987
  • Status: Expired due to Term
First Claim
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1. A toxin conjugate comprising (i) a mutant diphtheria toxin, wherein said mutant diphtheria toxin has a cell surface receptor binding site that binds to said cell surface receptor with an affinity lower than that of wild-type diphtheria toxin and a translocation function, and has an amino acid point mutation of serine residue 508 or of serine residue 525, covalently attached to (ii) a binding moiety which binds to a specific receptor;

  • wherein said translocation function is measured by a cytotoxicity assay using said conjugate and a cell expressing said specific receptor.

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