Dispensing devices powered by hydrogel

• US 5,792,471 A
• Filed: 04/19/1996
• Issued: 08/11/1998
• Est. Priority Date: 01/12/1989
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Curatolo, William J.
• Primary Examiner(s): VENKAT, JYOTHSNA A
• Application Number:
  US08/635,312
• Time in Patent Office: 844 Days
• Field of Search: 424/464, 424/467, 424/473, 424/480, 424/489, 424/494
• US Class Current: 424/480
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
• CPC Class Codes: A61M 31/002 Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time artificial gland structures or devices A61F2/022; intra-uterine contraceptive devices A61F6/14; tampons for introducing into the vagina A61F13/20, A61L15/00; suppositories or bougies for intra-vaginal or intra-uterine application A61K9/02; physical forms of medicinal preparations for sustained or differential drug release A61K9/20, A61K9/50

Abstract

This invention relates to devices useful for the controlled delivery of one or more beneficial agents to an environment of use. More specifically, this invention concerns such devices which are powered by hydrogel. This invention also relates to the controlled delivery of one or more beneficial agents to an aqueous environment of use through the use of such hydrogel powered dispensing devices. Also disclosed are methods for the controlled delivery of one or more beneficial agents to an aqueous environment of use which comprises administering to or otherwise placing the devices of this invention in the environment of use.

Claims

1. A tablet for releasing a drug to an external environment which comprises:

(a) an innermost hydrogel layer, said innermost hydrogel layer not including drug;

(b) a second layer, said second layer surrounding said innermost layer and said second layer comprising a mixture comprising one or more drugs and from about 50 to about 95 weight percent hydrogel, said hydrogel in said second layer being different from said hydrogel in said first layer; and

(c) a coating which surrounds the mixture and which comprises a polymer and one or more porosigens wherein the rate of drug release is relatively independent of the solubility of the drug.

2. The tablet according to claim 1 wherein the hydrogel is polyethylene oxide.

3. The tablet according to claim 2 wherein the coating polymer is cellulose acetate.

4. The tablet according to claim 3 wherein the porosigen is one or more water soluble polymers.

5. The tablet according to claim 4 wherein the water soluble polymer is selected from the group consisting of hydroxypropyl cellulose, polyethylene glycol and polyethylene oxide.

6. The tablet according to claim 3 wherein the porosigens are one or more water soluble polymers and one or more inorganic salts.

7. The tablet according to claim 3 wherein the porosigens are one or more water soluble polymers and one or more water soluble particulate organic compounds and the salts thereof.

8. The tablet according to claim 7 wherein the water soluble polymer is polyethylene glycol-600 and the water soluble particulate organic compound is sucrose.

9. The tablet according to claim 3 wherein the porosigen is one or more inorganic salts or one or more water soluble particulate organic compounds and salts thereof.

10. The tablet according to claim 1 wherein the mixture additionally comprises an osmotically effective solute.

11. The tablet according to claim 1 wherein the coating additionally contains at least one hole.

16. A method for the controlled delivery of one or more beneficial agents to an environment of use which comprises placing the tablet of claim 1 into the environment of use.

17. A method for the controlled delivery of a drug to an animal which comprises administering to the animal the tablet according to claim 1 wherein the beneficial agent is a drug.

12. A tablet for releasing a drug to an external environment which comprises:

(a) a first layer comprising a mixture of one or more beneficial agents and from about 50 to about 95 weight percent hydrogel;

(b) a second layer comprising hydrogel which second layer is adjacent to the first layer and comprises an area in contact with the first layer said second layer not including drug, said hydrogel in said second layer being different from said hydrogel in said first layer; and

(c) a coating which comprises a polymer and one or more porosigens and which coating surrounds the first and second layers except for said area in contact wherein the rate of drug release is relatively independent of the solubility of the drug.

13. The tablet according to claim 12 wherein the first layer additionally comprises an osmotically effective solute.

14. The tablet according to claim 12 wherein the second layer additionally comprises an osmotically effective solute.

15. The tablet according to claim 12 wherein the first and second layers each additionally comprise an osmotically effective solute.