Treatment for atherosclerosis and other cardiovascular and inflammatory diseases
First Claim
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1. A method for the suppression of VCAM- 1 expression in human cells comprising administering an effective amount of a compound of the formula R1 SC(S)NR2 R3, wherein R2 and R3 constitute a bridge of the formula --(CH2)m --, wherein m is 3-6, and R1 is H or a pharmaceutically acceptable cation.
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Abstract
Dithiocarboxylates, and in particular, dithiocarbamates, block the induced expression of the endothelial cell surface adhesion molecule VCAM-1, and are therefor useful in the treatment of cardiovascular disease, including atherosclerosis, post-angioplasty restenosis, coronary artery diseases, and angina, as well as noncardiovascular inflammatory diseases that are mediated by VCAM-1.
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4 Claims
- 1. A method for the suppression of VCAM- 1 expression in human cells comprising administering an effective amount of a compound of the formula R1 SC(S)NR2 R3, wherein R2 and R3 constitute a bridge of the formula --(CH2)m --, wherein m is 3-6, and R1 is H or a pharmaceutically acceptable cation.
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Current AssigneeEmory University
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Original AssigneeEmory University
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InventorsMedford, Russell M., Alexander, R. Wayne, Offermann, Margaret K.
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Primary Examiner(s)O SULLIVAN, PETER G
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Application NumberUS08/486,239Time in Patent Office1,161 DaysField of Search514/423, 514/210, 514/315, 514/478, 514/479, 514/484, 514/485, 514/487, 514/488, 514/489, 514/506, 514/513, 514/824, 514/825, 514/826, 514/861, 514/863, 548/531, 548/953, 546/245, 558/230, 558/235, 564/76, 568/21, 568/25US Class Current514/423CPC Class CodesA61K 31/325 Carbamic acids; Thiocarbami...A61K 31/40 having five-membered rings ...A61K 31/4453 only substituted in positio...A61K 31/55 having seven-membered rings...
