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2' Modified Oligonucleotides

  • US 5,792,847 A
  • Filed: 06/06/1995
  • Issued: 08/11/1998
  • Est. Priority Date: 10/24/1989
  • Status: Expired due to Term
First Claim
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1. An oligonucleotide having the formula ##STR6## or a salt thereof, wherein each B is independently a protected or unprotected purine or pyrimidine base in the β

  • -anomeric configuration;

    W3 and W4 are each independently H, PO3-2, a protecting group, or an intermediate moiety in the formation of an internucleotide link which when reacted with the appropriate --OH results in Z;

    each Z independently is P(O)O, P(O)S or P(O)N(R)2 ;

    each R is independently H or alkyl (1-6 C);

    n is an integer of 1-200;

    each A is independently selected from the group consisting of --X--Y, H, OH or --OPr wherein Pr is a protecting group whereinX is O;

    Y is substituted alkyl (2-20 C) or substituted or unsubstituted alkenyl (2-20 C), wherein the substituents are a halogen, OH, NH2, SH, --O--, --CH2 CONH2, --CH2 COOCH2 CH3 or --CH2 CONHCH2 CH2 NH2 ; and

    wherein at least one A is X--Y.

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