Method for treating ischemic brain stroke
First Claim
1. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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Abstract
A method for treating a patient sustaining an acute ischemic stroke in the brain. The brain has a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili. The method comprises at least partially occluding the first and second transverse venous sinuses in first and second locations, respectively, adjacent to the torcular Herophili to partially obstruct venous blood drainage while permitting some antegrade venous blood flow from at least one of the transverse venous sinuses. A flow of the patient'"'"'s arterial blood is introduced into at least one of the transverse venous sinuses to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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Citations
30 Claims
- 1. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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15. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit antegrade venous blood flow from at least one of said transverse venous sinuses so that it is within 10% to 50% of normal flow and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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16. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations causing the patient'"'"'s arterial blood initially to flow into the transverse venous sinus at a rate of 10 cc/minute and increasing the flow to 50-250 cc/minute over a period of time ranging from 3 to 10 minutes to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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17. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses from twenty-five per cent to seventy per cent of complete occlusion in first and second locations respectively adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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18. A method for treating a patient undergoing brain aneurysm clipping and brain tumor resection requiring arterial inflow occlusion, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively, adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the arterial inflow occlusion is relieved.
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19. A method for treating a patient sustaining a non-hemorrhagic angiographic injury in the brain, the brain having a blood circulatory system including a torcular Herophili and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising at least partially occluding the first and second transverse venous sinuses in first and second locations respectively, adjacent to the torcular Herophili to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit some antegrade venous blood flow from at least one of said transverse venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said transverse venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of brain injury symptoms.
- 20. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system comprising a torcular Herophili, first and second transverse venous sinuses adjoining the torcular Herophili, the patient having first and second venous vessels remote from the brain, by the use of first and second balloon catheters having proximal and distal extremities and having inflatable balloons on the distal extremities, the method comprising introducing the distal extremity of the first balloon catheter into the first vessel and thence into the first transverse venous sinus into close proximity to the torcular Herophili, introducing the distal extremity of the second balloon catheter into the second vessel and thence into the second transverse venous sinus into close proximity to the torcular Herophili, at least partially inflating the balloons of the first and second balloon catheters to at least partially occlude the first and second transverse sinuses while controlling the degree of said at least partially occluding the first and second transverse venous sinuses to permit antegrade flow from at least one of the transverse venous sinuses to prevent excessive pressure buildup in the transverse venous sinus, introducing a flow of the patient'"'"'s arterial blood into at least one of the transverse venous sinuses distal to the balloon positioned in that transverse venous sinus to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow, for a period of time up to when the patient exhibits resolution of at least some of the ischemic brain symptoms.
- 23. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a plurality of venous sinuses, the method comprising at least partially occluding first and second venous sinuses in first and second locations to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding first and second venous sinuses to permit some antegrade venous blood flow from at least one of said first and second venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said first and second venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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25. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a plurality of venous sinuses, the method comprising at least partially occluding first and second venous sinuses in first and second locations from five per cent to ninety-nine per cent of complete occlusion to obstruct venous blood drainage from said first and second venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said first and second venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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26. A method for treating a patient undergoing brain aneurysm clipping and brain tumor resection requiring arterial inflow occlusion, the brain having a blood circulatory system including a plurality of venous sinuses, the method comprising at least partially occluding first and second venous sinuses in first and second locations respectively, to partially obstruct venous blood drainage while controlling the degree of said at least partially occluding first and second venous sinuses to permit some antegrade venous blood flow from at least one of said first and second venous sinuses and introducing a flow of the patient'"'"'s arterial blood into at least one of said first and second venous sinuses distal to said locations to provide a substantially continuous retrograde blood flow into the venous side of the brain of the patient to overcome the lack of arterial blood flow for a period of time until the arterial inflow occlusion is relieved.
- 27. A method for treating a patient sustaining an acute ischemic stroke in the brain, the brain having a blood circulatory system including a torcular Herophill and first and second transverse venous sinuses adjoining the torcular Herophili, the method comprising introducing a substantially continuous retrograde flow of patient'"'"'s arterial blood into at least one of said transverse venous sinuses and into the venous side of the brain of the patient to overcome the lack of arterial blood flow at least partially occluding at lest one of the first and second transverse venous sinuses to permit some antegrade venous blood flow to prevent excessive pressure buildup in said transverse venous sinuses for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
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30. A method for treating a patient sustaining an acute ischomic stroke in the brain, the brain having a blood circulatory system including a plurality of venous sinuses, the method comprising introducing a substantially continuous retrograde flow of patient'"'"'s arterial blood into at least one of said venous sinuses and Into the venous side of the brain of the patient to overcome the lack of arterial blood flow at least partially occluding at least one of the first and second transverse venous sinuses to permit some antegrade venous blood flow to prevent excessive pressure buildup in said transverse venous sinuses for a period of time until the patient exhibits at least some resolution of ischemic brain symptoms.
Specification