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Inhibitors of NAALADase enzyme activity

  • US 5,795,877 A
  • Filed: 12/31/1996
  • Issued: 08/18/1998
  • Est. Priority Date: 12/31/1996
  • Status: Expired due to Term
First Claim
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1. A compound having the following formula:

  • ##STR13## where R is hydrogen, C1 -C9 straight or branched chain alkyl or alkenyl group, C3 -C8 cycloalkyl, C3 or C5 cycloalkyl, C5 -C7 cycloalkenyl, or Ar1, wherein said alkyl, alkenyl, cycloalkyl, cycloalkenyl or aryl groups are optionally substituted with C3 -C8 cycloalkyl, C3 or C5 cycloalkyl, C5 -C7 cycloalkenyl, C1 -C4 alkyl, C1 -C4 alkenyl, hydroxy, halo, hydroxyl, nitro, trifluoromethyl, C1 -C6 straight or branched chain alkyl or alkenyl, C1 -C4 alkoxy, C1 -C4 alkenyloxy, phenoxy, benzyloxy, amino, or Ar1, and where Ar1 is selected from the group consisting of 1-naphthyl, 2-naphthyl, and phenyl, having one to three substituents which are independently selected from the group consisting of hydrogen, halo, hydroxyl, nitro, trifluoromethyl, C1 -C6 straight or branched alkyl or alkenyl, C1 -C4 alkoxy or C1 -C4 alkenyloxy, phenoxy, benzyloxy, and amino;

    or pharmaceutically acceptable salts or hydrates thereof.

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