3-substituted 2-oxindole-1 carboxamide pharmaceutical compositions

• US 5,795,902 A
• Filed: 09/19/1996
• Issued: 08/18/1998
• Est. Priority Date: 09/02/1993
• Status: Expired due to Fees

• Current Assignee: Pfizer Inc.
• Original Assignee: Pfizer Inc.
• Inventors: Ahmed, Imram
• Primary Examiner(s): MacMillan, Keith D.
• Application Number:
  US08/715,748
• Time in Patent Office: 698 Days
• Field of Search: 514/354, 514/434, 514/418, 514/912, 514/814, 514/415, 514/419, 514/414
• US Class Current: 514/354
• CPC Class Codes: A61K 31/404 Indoles, e.g. pindolol

Abstract

The present invention relates to a pharmaceutical preparation comprising: (A) at least one triglyceride or propylene glycol diester of fractionated coconut oil fatty acids; and (B) at least one carboxamide compound of the formula I. The composition renders the carboxamides of formula I more storage-stable and less susceptible to hydrolysis. Methods of using the composition to inhibit activation of collagenase, treating inflammatory disease, and eliciting an analgesic response are also disclosed.

Claims

1. A pharmaceutical preparation comprising:

(A) at least one triglyceride or propylene glycol diester of fractionated coconut oil fatty acids, wherein said coconut oil fatty acids include C₈ to C₁₀ fatty acids; and

(B) at least one compound of the formula ##STR2## where R₁, R₂, and R₃ are each independently hydrogen, fluoro, bromo, or chloro, or a pharmaceutically acceptable salt thereof,

wherein the ratio of % by weight of (A) to % by weight of (B) ranges from 5.6 to 999.

2. The pharmaceutical preparation of claim 1, wherein the compound of formula I is 5-chloro-2,3-dihydro-2-oxo-3-(2-thienyl-carbonyl)-indole-carboxamide.

3. The pharmaceutical preparation of claim 1, wherein said coconut oil fatty acids comprises caprylic acid, caproic acid, lauric acid, and linoleic acid.