Horseshoe crab amebocyte lysate factor G subunit A
First Claim
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1. An isolated polypeptide having an amino acid sequence defined by amino acid residue numbers 1-654 in SEQ ID No. 2.
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Abstract
This invention relates to a DNA shown by SEQ ID No. 1 and an amino acid sequence coded by said DNA. This invention also relates to a DNA and an amino acid sequence of subunit a of (1→3)-β-D-glucan sensitive factor derived from amebocytes of horseshoe crab and have potent affinity to (1→3)-β-D-glucan in cell walls of fungi. Therefore, the invention is useful for the diagnosis of fungal diseases and as antimicrobial or eradicating agent of fungi in combination with an antifungal agent.
34 Citations
4 Claims
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1. An isolated polypeptide having an amino acid sequence defined by amino acid residue numbers 1-654 in SEQ ID No. 2.
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2. An isolated polypeptide having an amino acid sequence defined by amino acid residue numbers 4-236 in SEQ ID No. 2.
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3. An isolated polypeptide having an amino acid sequence defined by amino acid residue numbers 247-387 in SEQ ID No. 2.
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4. An isolated polypeptide having an amino acid sequence defined by amino acid residue numbers 391-654 in SEQ ID No. 2.
Specification
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Current AssigneeSeikagaku Kogyo Kabushiki Kaisha
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Original AssigneeSeikagaku Kogyo Kabushiki Kaisha
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InventorsSeki, Noriaki, Oda, Toshio, Muta, Tatsushi, Iwanaga, Sadaaki
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Primary Examiner(s)GRIMES, ERIC BURTON
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Application NumberUS08/392,828Time in Patent Office1,267 DaysField of Search435/219, 435/226, 530/350, 530/324US Class Current530/350CPC Class CodesC07K 14/43509 from crustaceansC12N 15/8282 for fungal resistanceG01N 33/579 involving limulus lysate
