Tissue heating and ablation systems and methods using porous electrode structures with electrically conductive surfaces

• US 5,797,903 A
• Filed: 04/12/1996
• Issued: 08/25/1998
• Est. Priority Date: 04/12/1996
• Status: Expired due to Term

• Current Assignee: EP Technologies Incorporated (Boston Scientific Corporation)
• Original Assignee: EP Technologies Incorporated (Boston Scientific Corporation)
• Inventors: Panescu, Dorin, Swanson, David K., Whayne, James G., Thompson, Russell B., Owens, Patrick M.
• Primary Examiner(s): Cohen, Lee S.
• Application Number:
  US08/631,252
• Time in Patent Office: 865 Days
• Field of Search: 606/41, 606/34, 606/33, 928/642, 607/99, 607/105, 607/113, 607/122, 604/21, 600/374
• US Class Current: 606/34
• CPC Class Codes: A61B 2018/00267 having a basket shaped structure
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: C08L 1/02 Cellulose; Modified cellulose

Abstract

Tissue heating and ablation systems and methods use a porous electrode assembly with an electrically conductive surface. The electrode assembly includes an exterior peripherally surrounding an interior area. At least a portion of the wall comprises an electrically conductive material. A lumen conveys a medium containing ions into the interior area. According to the invention, at least a portion of the wall also comprising a porous material sized to pass ions contained in the medium. In a preferred embodiment, the electrode assembly further includes an element coupling the electrically conductive material to a source of electrical energy to transmit electrical energy. In this preferred embodiment, the electrically conductive material is also porous to pass ions contained in the medium. The assembly also preferably includes a conductive element coupling the medium within the interior area to a source of electrical energy to enable ionic transport of electrical energy by the medium through the porous material.

Claims

1. An electrode assembly comprising

a wall having an exterior peripherally surrounding an interior area,

at least a portion of the wall comprising an electrically conductive material, and

a lumen for conveying a medium containing ions into the interior area,

wherein at least a portion of the wall also comprises a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material.

2. An assembly according to claim 1

wherein the porous material is adjacent to the electrically conductive material.

3. An assembly according to claim 1 or 2

and further including an element for coupling the electrically conductive material to a source of electrical energy to transmit electrical energy.

4. An assembly according to claim 3

wherein the electrically conductive material is also porous to pass ions contained in the medium.

5. An assembly according to claim 3

and further including a conductive element for coupling the medium within the interior area to a source of electrical energy to enable ionic transport of electrical energy by the medium through the porous material.

6. An assembly according to claim 5

wherein the conductive element comprises an electrically conductive electrode in the interior area of the wall.

7. An assembly according to claim 6

wherein the electrically conductive electrode comprises a nobel metal.

8. An assembly according to claim 7

wherein the electrically conductive electrode includes a material selected from the group consisting essentially of gold, platinum, platinum/iridium, and combinations thereof.

9. An assembly according to claim 5

wherein the electrically conductive material is also porous to pass ions contained in the medium.

10. An assembly according to claim 1 or 2

and further including an element coupled to the electrically conductive material to convey electrical signals sensed by the electrically conductive material.

11. An assembly according to claim 10

and further including an element for coupling the electrically conductive material to a source of electrical energy to transmit electrical energy.

12. An assembly according to claim 11

wherein the electrically conductive material is also porous to pass ions contained in the medium.

13. An assembly according to claim 11

and further including a conductive element for coupling the medium within the interior area to a source of electrical energy to enable ionic transport of electrical energy by the medium through the porous material.

14. An assembly according to claim 13

wherein the conductive element comprises an electrically conductive electrode in the interior area of the wall.

15. An assembly according to claim 14

wherein the electrically conductive electrode comprises a noble metal.

16. An assembly according to claim 15

wherein the electrically conductive electrode includes a material selected from the group consisting essentially of gold, platinum, platinum/iridium, and combinations thereof.

17. An assembly according to claim 13

wherein the electrically conductive material is also porous to pass ions contained in the medium.

31. An assembly according to claim 1 or 18

wherein the electrically conductive material comprises a coating deposited on the wall.

32. An assembly according to claim 1 or 18

wherein the electrically conductive material comprises foil affixed to the wall.

33. An assembly according to claim 1 or 18

wherein the electrically conductive material is a coextruded part of the wall.

34. An assembly according to claim 1 or 18

wherein the electrically conductive material comprises noninsulated signal wire exposed on the exterior of the wall.

35. An assembly according to claim 1 or 18

wherein the medium comprises a hypertonic solution.

36. An assembly according to claim 35

wherein the hypertonic solution includes sodium chloride.

37. An assembly according to claim 36

wherein the sodium chloride is present in a concentration at or near saturation.

38. An assembly according to claim 36

wherein the sodium chloride is present in a concentration of up to about 9% weight by volume.

39. An assembly according to claim 35

wherein the hypertonic solution includes potassium chloride.

40. An assembly according to claim 1 or 18

wherein the medium has a resistivity lower than about 150 ohm·

cm.

41. An assembly according to claim 1 or 18

wherein the medium has a resistivity lower than about 10 ohm·

cm.

42. An assembly according to claim 1 or 18

wherein the medium has a resistivity of about 5 ohm·

cm.

43. An assembly according to claim 1 or 18

wherein the medium includes a material whose presence increases viscosity of the medium.

44. An assembly according to claim 1 or 18

wherein the medium includes at least one ionic material whose presence increases viscosity of the medium.

45. An assembly according to claim 44

wherein the at least one ionic material comprises a radiopaque substance.

46. An assembly according to claim 1 or 18

wherein the medium includes a nonionic material whose presence increases viscosity of the medium.

47. An assembly according to claim 46

wherein the nonionic material includes glycerol.

48. An assembly according to claim 46

wherein the nonionic material includes mannitol.

49. An assembly according to claim 1 or 18

wherein the porous material has an electrical resistivity greater than about 500 ohm·

cm.

50. An assembly according to claim 1 or 18

wherein the porous material has an electrical resistivity less than about 500 ohm·

cm.

51. An assembly according to claim 1 or 18

and further including members assembled within the interior area to form a support structure underlying the wall.

52. An assembly according to claim 51

wherein the support members are made from metal material.

53. An assembly according to claim 52

wherein the metal material includes nickel titanium.

54. An assembly according to claim 52

wherein the metal material includes stainless steel.

55. An assembly according to claim 52

wherein the support members are made from plastic material.

56. An assembly according to claim 52

wherein the support members comprise elongated spline elements assembled in a circumferentially spaced relationship.

57. An assembly according to claim 52 wherein the support members comprise a porous foam structure.

58. An assembly according to claim 1 or 18

wherein the porous material is hydrophilic.

59. An assembly according to claim 1 or 18

wherein the lumens conveys a medium containing ions into the interior area subject to an interior pressure, and

wherein the porous material has a bubble point value greater than the interior pressure.

60. An assembly according to claim 59

wherein the porous material is hydrophilic.

18. An electrode assembly comprising

a wall having an exterior peripherally surrounding an interior area,

at least a portion of the wall comprising an electrically conductive material,

a lumen for conveying a medium containing ions into the interior area, and

a conductive element for coupling the medium within the interior area to a source of electrical energy to enable ionic transport of electrical energy by the medium,

wherein at least a portion of the wall also comprises a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material to enable ionic transport of electrical energy by the medium through the porous material to the exterior of the wall.

19. An assembly according to claim 18

wherein the porous material is adjacent to the electrically conductive material.

20. An assembly according to claim 18 or 19

and further including an element for coupling the electrically conductive material to a source of electrical energy to transmit electrical energy.

21. An assembly according to claim 20

wherein the electrically conductive material is also porous to pass ions contained in the medium.

22. An assembly according to claim 18 or 19

and further including an element coupled to the electrically conductive material to convey electrical signals sensed by the electrically conductive material.

23. An assembly according to claim 22

and further including an element for coupling the electrically conductive material to a source of electrical energy to transmit electrical energy.

24. An assembly according to claim 23

wherein the electrically conductive material is also porous to pass ions contained in the medium.

25. An assembly according to claim 18 or 19

wherein the conductive element comprises an electrically conductive electrode in the interior area of the wall.

26. An assembly according to claim 25

wherein the electrically conductive electrode comprises a noble metal.

27. An assembly according to claim 25

wherein the electrically conductive electrode includes a material selected from the group consisting essentially of gold, platinum, platinum/iridium, and combinations thereof.

28. An assembly according to claim 18 or 19

wherein the porous material is sized to block passage of macromolecules.

29. An assembly according to claim 18 or

wherein the porous material comprises an ultrafiltration membrane.

30. An assembly according to claim 18 or 19

wherein the porous material comprises a microporous membrane.

61. A system for heating body tissue comprising

a source of a medium containing ions,

a generator of electrical energy,

an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen for conveying medium containing ions from the source into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material, and

a controller coupled to the souce and to the generator to achieve a desired tissue heating effect by commanding conveyance of electrical energy by the generator for transmission by the electrically conductive material while commanding conveyance of medium containing ions by the source, thereby enabling ionic transport through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission that is greater than the surface area of the electrically conductive material.

62. A system according to claim 61

and further including a conductive element coupling the medium within the interior area of the wall to the generator, and

wherein the controller is coupled to the conductive element to command conveyance of electrical energy by the generator to the element to enable ionic transport of electrical energy by the medium through the porous material while the electrically conductive material transmits electrical energy.

64. A system according to claim 61 or 62 or 63

wherein the controller is operative for achieving the desired tissue heating effect by ablating body tissue.

65. A system according to claim 61 or 62 or 63

wherein the controller is operative for achieving the desired tissue heating effect by ablating heart tissue.

72. A system according to claim 62 or 63 or 67 or 68

wherein the conductive element comprises an electrically conductive electrode in the interior area of the wall.

73. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the electrically conductive material comprises a coating deposited on the wall.

74. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the electrically conductive material comprises foil affixed to the wall.

75. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the electrically conductive material is a coextruded part of the wall.

76. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the electrically conductive material comprises noninsulated signal wire exposed on the exterior of the wall.

77. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the medium comprises a hypertonic solution.

78. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the medium has a resistivity lower than about 150 ohm·

cm.

79. A system according to claim 78

wherein the medium has a resistivity lower than about 10 ohm·

cm.

80. A system according to claim 78

wherein the medium has a resistivity of about 5 ohm·

cm.

81. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the porous material has an electrical resistivity greater than about 500 ohm·

cm.

82. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the porous material has an electrical resistivity less than about 500 ohm·

cm.

83. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the porous material is hydrophilic.

84. A system according to claim 61 or 62 or 63 or 66 or 67 or 68

wherein the lumens conveys a medium containing ions into the interior area subject to an interior pressure, and

wherein the porous material has a bubble point value greater than the interior pressure.

85. A system according to claim 84

wherein the porous material is hydrophilic.

63. A system for heating body tissue comprising

a source of a medium containing ions,

a generator of electrical energy,

an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen to convey medium containing ions from the source into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium,

a conductive element coupling the medium within the interior area of the wall to the generator, and

a controller coupled to the source, the generator, and the element to achieve a desired tissue heating effect by commanding conveyance of electrical energy by the generator to the element and the electrically conductive material while commanding conveyance of medium containing ions by the source into the interior area to enable ionic transport of electrical energy through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission that is greater than the surface area of the electrically conductive material.

69. A system according to claim 63 or 67 or 68

wherein the porous material is sized to block passage of macromolecules.

70. A system according to claim 63 or 68

wherein the porous material comprises an ultrafiltration membrane.

71. A system according to claim 63 or 68

wherein the porous material comprises a microporous membrane.

66. A system for ablating heart tissue comprising

a source of a medium containing ions,

a generator of electrical energy,

a processor for processing electrical events sensed in heart tissue,

an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for sensing electrical events in heart tissue and transmitting electrical energy, a lumen for conveying medium containing ions from the source into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material, and

a controller coupled to the source, to the generator, and to the processor, the controller operative in a first mode commanding the electrically conductive material to sense electrical events in heart tissue for conveyance to the processor, the controller being operative in a second mode commanding conveyance of electrical energy by the generator for transmission by the electrically conductive material while commanding conveyance of medium containing ions, thereby enabling ionic transport through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission for ablating heart tissue that is greater than the surface area of the electrically conductive material.

67. A system according to claim 66

and further including a conductive element coupling the medium within the interior area of the wall to the generator, and

wherein the controller is coupled to the element to command, during the second mode, conveyance of electrical energy by the generator to the element to enable ionic transport of electrical energy by the medium through the porous material while the electrically conductive material transmits electrical energy.

68. A system for ablating heart tissue comprising

a source of a medium containing ions,

a generator of electrical energy,

a processor for processing electrical events sensed in heart tissue,

an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for sensing electrical events in heart tissue and transmitting electrical energy, a lumen to convey medium containing ions from the source into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium,

a conductive element coupling the medium within the interior area of the wall to the generator, and

a controller coupled to the source, to the generator, and to the processor, the controller operative in a first mode commanding the electrically conductive material to sense electrical events in heart tissue for conveyance to the processor, the controller being operative in a second mode commanding conveyance of electrical energy by the generator for transmission by the electrically conductive material while commanding conveyance of medium containing ions by the source into the interior area to enable ionic transport of electrical energy through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission for ablating heart tissue that is greater than the surface area of the electrically conductive material.

86. A method for heating body tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen for conveying a medium containing ions into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material,

electrically coupling a source of radio frequency energy to the electrically conductive material to a return electrode in contact with body tissue,

guiding the catheter tube into a body, and

ohmically heating body tissue by transmitting radio frequency through the electrically conductive material while conveying medium containing ions into the interior area of the wall to enable ions transport through the porous material while the electrically conductive material transmits electrical energy, thereby creating an effective surface area of electrical energy transmission to the return electrode that is greater than the surface area of the electrically conductive material.

87. A method for ablating body tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen for conveying a medium containing ions into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material,

electrically coupling a source of radio frequency energy to the electrically conductive material to a return electrode in contact with body tissue,

guiding the catheter tube into a body, and

ohmically ablating body tissue by transmitting radio frequency through the electrically conductive material while conveying medium containing ions into the interior area of the wall to enable ionic transport through the porous material while the electrically conductive material transmits electrical energy, thereby creating an effective surface area of electrical energy transmission to the return electrode that is greater than the surface area of the electrically conductive material.

88. A method for ablating heart tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen for conveying a medium containing ions into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material,

electrically coupling a source of radio frequency energy to the electrically conductive material to a return electrode in contact with heart tissue,

guiding the catheter tube into a heart chamber, and

ohmically ablating heart tissue by transmitting radio frequency through the electrically conductive material while conveying medium containing ions into the interior area of the wall to enable ionic transport through the porous material while the electrically conductive material transmits electrical energy, thereby creating an effective surface area of electrical energy transmission to the return electrode that is greater than the surface area of the electrically conductive material.

89. A method according to claim 88

and further including the step of conditioning the electrically conductive material to sense electrical events in heart tissue.

90. A method for heating body tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen to convey medium containing ions into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium, and an electrically conductive element contacting the medium within the interior area of the wall, and

electrically coupling the electrically conductive element and the electrically conductive material to a source of radio frequency energy and to a return electrode in contact with body tissue,

guiding the catheter tube into a body, and

ohmically heating body tissue by transmitting radio frequency through the electrically conductive material and the element while conveying medium containing ions into the interior area of the wall to enable ionic transport of electrical energy through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission to the return electrode that is greater than the surface area of the electrically conductive material.

91. A method for ablating body tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen to convey medium containing ions into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium, and an electrically conductive element contacting the medium within the interior area of the wall, and

electrically coupling the electrically conductive element and the electrically conductive material to a source of radio frequency energy and to a return electrode in contact with body tissue,

guiding the catheter tube into a body, and

ohmically ablating body tissue by transmitting radio frequency through the electrically conductive material and the element while conveying medium containing ions into the interior area of the wall to enable ionic transport of electrical energy through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission to the return electrode that is greater than the surface area of the electrically conductive material.

92. A method for ablating heart tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material having a surface area for transmitting electrical energy, a lumen to convey medium containing ions into the interior area of the wall, at least a portion of the wall adjacent to the electrically conductive material comprising a porous material sized to pass ions contained in the medium, and an electrically conductive element contacting the medium within the interior area of the wall, and

electrically coupling the electrically conductive element and the electrically conductive material to a source of radio frequency energy and to a return electrode in contact with body tissue,

guiding the catheter tube into a heart chamber, and

ohmically ablating heart tissue by transmitting radio frequency through the electrically conductive material and the element while conveying medium containing ions into the interior area of the wall to enable ionic transport of electrical energy through the porous material while the electrically conductive material transmits electrical energy to create an effective surface area of electrical energy transmission to the return electrode that is greater than the surface area of the electrically conductive material.

93. A method according to claim 92

and further including the step of conditioning the electrically conductive material to sense electrical events in heart tissue.

94. A system for heating body tissue comprising

a source of a medium containing ions,

a generator of electrical energy,

an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material adapted to be coupled to a source of electrical energy to transmit electrical energy, a lumen for conveying a medium containing ions into the interior area, and at least a portion of the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material, and

a controller adapted to be coupled to the source and to the generator to achieve a desired tissue heating effect by commanding conveyance of electrical energy by the generator for transmission by the electrically conductive material while commanding conveyance of medium containing ions by the source, thereby enabling ionic transport through the porous material while the electrically conductive material transmits electrical energy.

95. A system according to claim 94

and further including a conductive element coupling the medium within the interior area of the wall to the generator, and

wherein the controller is coupled to the conductive element to command conveyance of electrical energy by the generator to the element to enable ionic transport of electrical energy by the medium through the porous material while the electrically conductive material transmits electrical energy.

96. A system according to claim 94 further including a processor for processing electrical events sensed in the tissue, the controller also coupled to the processor, the controller operative in a first mode commanding the electrically conductive material to sense electrical events in the tissue for conveyance to he processor, the controller being operative in a second mode commanding conveyance of electrical energy by the generator for transmission by the electrically conductive material while commanding conveyance of medium containing ions, thereby enabling ionic transport through the porous material while the electrically conductive material transmits electrical energy.

97. A method for heating body tissue comprising the steps of

providing a catheter tube having a distal end that carries an electrode comprising a wall having an exterior peripherally surrounding an interior area, at least a portion of the wall comprising an electrically conductive material adapted to be coupled to a source of electrical energy to transmit electrical energy, a lumen for conveying a medium containing ions into the interior area, at least a portion of the electrically conductive material comprising a porous material sized to pass ions contained in the medium without allowing substantial medium perfusion through the porous material,

electrically coupling a source of radio frequency energy to the electrically conductive material to a return electrode in contact with body tissue,

guiding the catheter tube into a body, and

ohmically heating body tissue by transmitting radio frequency through the electrically conductive material while conveying medium containing ions into the interior area of the wall to enable ionic transport through the porous material while the electrically conductive material transmits electrical energy.

98. A method according to claim 97

and further including the step of conditioning the electrically conductive material to sense electrical events in the tissue.

99. A method according to claim 97

and further including an electrically conductive element in the medium that is in contact within the interior area of the wall, the step of electrically coupling the electrically conductive element and the electrically conductive material to a source of a radio frequency energy and to a return electrode in contact with body tissue, and the step of ohmically heating body tissue by transmitting radio frequency through the porous material while the electrically conductive material transmits electrical energy.