System and method to reduce defibrillation requirements

• US 5,797,967 A
• Filed: 09/27/1996
• Issued: 08/25/1998
• Est. Priority Date: 09/27/1996
• Status: Expired due to Term

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: KenKnight, Bruce H.
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US08/720,360
• Time in Patent Office: 697 Days
• Field of Search: 607/5, 607/6, 607/7, 607/8, 607/4
• US Class Current: 607/4
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

A hybrid tachyarrhythmia therapy utilizes a combination of two therapies: pacing therapy (optionally followed by therapy employing waveforms having morphologies congruent to defibrillation waveforms but at reduced-strength); and defibrillation (including cardioversion) therapy. The two therapies are applied in either a temporally coincident, or an immediately sequential, fashion. At least one pacing pulse that influences only a localized portion of selected cardiac tissue is applied, prior to or coincident with at least one defibrillation-level shock. The defibrillation shock strength (voltage and/or energy) required to terminate the tachyarrhythmia is less than would be required in the absence of the critically-coupled pacing pulses. The therapy may be applied to atrial or ventricular tachyarrhythmias. A variety of electrode configurations and defibrillation pulse schemes may be employed.

Claims

1. A method of treating cardiac arrhythmia, comprising application by an implantable pacing electrode system of at least one exogenous pacing level shock to at least one region of fibrillating myocardium of selected cardiac tissue, any such region being characterized by a 1:

1 phase lock of a local electrogram of that region to a stimulus artifact in that region, such that invasion of intrinsic fibrillation wavefronts into at least one region of fibrillating myocardium is prevented.

17. The method of any of claims 1, 2, 6, 7, 8, 9, 10, or 11, in which the selected cardiac tissue is ventricular tissue.

18. The method of any of claims 1, 2, 6, 7, 8, 9, 10, or 11, in which the selected cardiac tissue is atrial tissue, and the method further comprises postponing application of any defibrillation-level shock which would occur within the T-wave of ventricular activation cycle until after ventricular depolarization.

2. A method of applying therapeutic electrical energy to a heart, comprising application by an implantable pacing electrode system of a plurality of different shock strength profiles corresponding to at least one pacing level shock strength to a plurality of regions of selected cardiac tissue, in which the regions have characteristically different arrhythmias convertible to other states by mechanisms which differ from each other, and selecting each of the plurality of shock strength profiles to correspond to each of the plurality of regions according to ability of the profile to provide increased periodicity in each region, such that predictable activation is created in at least one particular region.

3. The method of claim 2, in which the predictable activation is conversion to normal sinus rhythm.

4. The method of claim 2, in which the predictable activation is conversion to a state which may in turn be converted to normal sinus rhythm by application of at least one defibrillation-level shock.

5. The method of claim 4, in which the predictable activation is conversion to near-normal sinus rhythm.

6. A method of treating cardiac arrhythmia, comprising the steps of applying at least one pacing level shock to selected cardiac tissue having a relatively low susceptibility to defibrillation-level shock field strength by an implantable pacing level electrode system to create a predictable repolarization state, followed by activating the selected cardiac tissue in a periodic manner to reduce shock strength requirements of a defibrillation-level shock subsequently applied to the selected cardiac tissue by a separate implantable defibrillation electrode system.

7. A method of treating cardiac arrhythmia, comprising the steps of:

(a) determining a region of selected cardiac tissue having relatively low susceptibility to defibrillation-level shock field strength,

(b) applying a plurality of pacing pulses to the region of selected cardiac tissue by an implantable sub-defibrillation level electrode system, and

(c) applying at least one defibrillation-level shock to the selected cardiac tissue by a separate implantable defibrillation electrode system coincident with or after a last pacing pulse.

8. A method of treating cardiac arrhythmia in which, coincident with or after the application of a first defibrillation-level shock to a heart, at least one pacing pulse is applied by an implantable pacing electrode system to a localized portion of a region of selected cardiac tissue having relatively low susceptibility to a defibrillation-level shock field strength, to reduce the strength required for the first defibrillation-level shock to defibrillate the heart by a separate implantable defibrillation electrode system.

9. A method of treating cardiac arrhythmia, comprising the steps of applying a series of pacing pulses to selected cardiac tissue having a relatively low susceptibility to defibrillation-level shock field strength, and application of at least one sub-defibrillation-level shock to the selected cardiac tissue by an implantable sub-defibrillation level electrode system, in which a first sub-defibrillation level shock occurs coincident with or after the application of a last of the series of pacing-level shocks.

10. A method of treating cardiac arrhythmia, comprising application of at least one pacing pulse to selected cardiac tissue by an implantable pacing electrode system, and coordinating delivery of at least one defibrillation shock by a separate implantable defibrillation level electrode system to the pacing pulse applied in at least one area of the selected cardiac tissue where the electric field intensity induced by the defibrillation-level shock is weak, and controlling timing of a last pacing pulse to occur coincident with or after a first defibrillation-level shock.

14. The method of any of claims 7, 9, 10, or 11, in which the pacing pulse is applied prior to the application of the first defibrillation-level shock.

15. The method of claim 14 in which a last pacing pulse occurs within about one mean activation interval, calculated immediately prior to a first sub-defibrillation-level shock, from the first defibrillation-level shock.

16. The method of any of claims 7, 8, 9, 10, or 11, in which the pacing pulse is applied simultaneously with the application of the first defibrillation-level shock.

11. A method of treating cardiac arrhythmia, comprising applying at least one pacing pulse by an implantable pacing electrode system to exert control over fibrillating myocardium located in selected cardiac tissue having a relatively low susceptibility to defibrillation-level shock field strength, and controlling timing of a last repetition of an applied pacing pulse to occur coincident with or after a first defibrillation-level shock is delivered by an implantable defibrillation electrode system.

12. The method of claim 11, in which more than one pacing pulse is applied to produce control exerted over successive regions of fibrillating myocardium.

13. The method of claim 11, in which the application of any pacing pulse produces a region of fibrillating myocardium characterized by a 1:

1 phase lock of a local electrogram to a stimulus artifact of that region.

19. A system for applying therapeutic electrical energy to a heart, comprising a first generator of a plurality of pacing pulses, a second generator of at least one defibrillation-level shock, a first electrode system coupled to the first generator for delivering the pacing pulses to a first location including at least a region of selected cardiac tissue having a relatively low susceptibility to defibrillation-level shock field strength, a second electrode system coupled to the second generator for delivering the defibrillation-level shock to the heart from a second location, in which the system further comprises timers which control delivery of a first defibrillation-level shock to occur coincident with or after the delivery of a last pacing pulse.

20. The system of claim 19 in which the system applies the first pacing pulse prior to when the system applies the first defibrillation shock.

21. The system of claim 19 in which a last pacing pulse occurs within about one mean activation interval, calculated immediately prior to a first pacing pulse, from the first defibrillation shock.

22. The system of claim 19 in which the last pacing pulse is applied simultaneously with the application of the first defibrillation shock.

23. The system of claim 19 in which the selected cardiac tissue is ventricular tissue.

24. The system of claim 19 in which the selected cardiac tissue is atrial tissue, and the timers further postpone application of any defibrillation-level shock which would occur within the T-wave of ventricular activation cycle until after ventricular depolarization.

25. The system of claim 19, in which the second generator further includes a capacitor network, where the capacitor network has a capacitance in the range of 20 to 400 μ

F, and where the second generator generates at least one sub-defibrillation-level shock having morphology congruent with a defibrillation-level shock but strength below a defibrillation threshold of the selected cardiac tissue, by terminating the discharge waveform of the capacitor network.

26. The system of claim 25 in which the at least one sub-defibrillation-level shock is a pacing-level shock.

27. The system of claim 25, in which the capacitor network comprises at least one capacitor used for applying at least one defibrillation-level shock.

28. The system of claim 19 in which the first and second generators are combined into a single implantable device.