Refillable body powered drug delivery techniques

• US 5,798,114 A
• Filed: 04/30/1996
• Issued: 08/25/1998
• Est. Priority Date: 04/30/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Kim, Robert E., Elsberry, Dennis D.
• Primary Examiner(s): Azpuru, Carlos
• Application Number:
  US08/640,360
• Time in Patent Office: 847 Days
• Field of Search: 424/423, 604/892.1
• US Class Current: 424/423
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L

Abstract

Techniques for implanting and refilling a device for delivering a treatment agent to a body. First and second chambers for holding treatment agent and delivery agent, respectively, are placed adjacent docking compartments adapted to receive a hypodermic needle through septums so that the expended delivery agent can be withdrawn and a new supply of treatment agent can be introduced without removing the device from its implanted position in a body.

Claims

1. An implantable and refillable dispensing device for delivering a treatment agent to a body comprising in combination:

a first chamber for holding said treatment agent;

a conduit between said first chamber and said body;

a second chamber for holding a delivery agent;

means for applying pressure to said first chamber due to changes in volume of said delivery agent in said second chamber so that said treatment agent is delivered through said conduit to said body;

septum means for facilitating the introduction of treatment agent into said first chamber and for facilitating the removal of delivery agent from said second chamber, whereby said treatment agent can be introduced into said first chamber and said delivery fluid can be withdrawn from said second chamber using a rejuvenating device, while said dispensing device remains implanted in the body.

2. A device, as claimed in claim 1, wherein said treatment agent comprises a drug.

3. A device, as claimed in claim 1, wherein said conduit comprises a one way valve.

4. A device, as claimed in claim 1, wherein said delivery agent comprises a hydrophilic medium.

5. A device, as claimed in claim 1, wherein said delivery agent comprises a sodium chloride solution.

6. A device, as claimed in claim 1, wherein said delivery agent comprises a hydrophilic hydropolymer.

7. A device, as claimed in claim 1, wherein said means for applying pressure comprises a plunger.

8. A device, as claimed in claim 1, wherein said means for applying pressure comprises an impermeable plastic sheet.

9. A device, as claimed in claim 1, wherein said septum means comprises a first septum for separating said first chamber from said second chamber and a second septum for separating said device from said body.

10. A device, as claimed in claim 9, wherein said first chamber comprises a first docking compartment, and wherein said second chamber comprises a second docking compartment, and wherein said first septum separates said first docking compartment from said second docking compartment, wherein said second septum separates said first docking compartment from said body, and wherein said first and second septums are aligned whereby said treatment agent can be introduced into said first chamber and said delivery fluid can be withdrawn from said second chamber by one or more hypodermic needles without removing said device from said body.

11. A device, as claimed in claim 10, wherein said hypodermic needle comprises a first lumen and a second lumen, wherein said first lumen is coupled to said first docking compartment, wherein said second lumen is coupled to said second docking compartment and wherein said first septum separates said first and second lumens.

12. A device, as claimed in claim 1, wherein said means for applying pressure comprise a bellows.

13. A dispensing device for delivering a treatment agent to a body comprising:

a treatment agent chamber for holding the treatment agent;

a delivery agent chamber for holding a supply of delivery agent;

a conduit for permitting egress of the treatment agent from the treatment agent chamber to the body;

means for applying pressure to the treatment agent chamber due to changes in volume of the delivery agent in the delivery agent chamber so that the treatment agent is delivered through the conduit to the body; and

a first septum for permitting a rejuvenating device to selectively communicate with the treatment agent chamber to supply treatment agent thereto.

14. The device according to claim 13, further comprising a second septum for permitting a rejuvenating device to selectively communicate with the delivery agent chamber to remove delivery agent therefrom.

15. The device according to claim 13, wherein the first septum partially separates the treatment agent chamber from the delivery agent chamber.

16. The device according to claim 13, wherein the means for applying pressure comprises a movable plunger.

17. The device according to claim 13, wherein the means for applying pressure comprises a bellows.

18. The device according to claim 13, wherein the means for applying pressure comprises a plastic sheet.

19. The device according to claim 13, further comprising a semi-permeable membrane for permitting ingress of fluid from the body to the delivery agent chamber.

20. The device according to claim 14, wherein at least one of the first septum and the second septum is comprised of a self-sealing material.

21. The device according to claim 14, wherein at least one of the first septum and the second septum is comprised of a material selected from the group consisting of polysiloxane elastomer, fluoroelastomer or composite elastomers of polyfluorosilicone.

22. An implantable dispensing device for deliverying a treatment agent to a body comprising:

a main chamber including a treatment agent chamber for containing a treatment agent and a delivery agent chamber for containing delivery agent;

a conduit for permitting egress of treatment agent from the treatment agent chamber to the body;

means for applying pressure to the treatment agent chamber due to changes in volume of the delivery agent in the delivery agent chamber so that the treatment agent is delivered through the conduit to the body; and

a docking compartment, in communication with the main chamber, for facilitating selective communication of the treatment agent chamber and the delivery agent chamber with a rejuvenating device adapted to remove a supply of exhausted delivery agent from the delivery agent chamber and to introduce a fresh supply of treatment agent to the treatment agent chamber.

23. The device according to claim 22, wherein the docking compartment comprises a first septum for permitting selective communication of the delivery agent chamber with the rejuvenating device.

24. The device according to claim 23, wherein the docking compartment includes a second septum for permitting selective communication of the treatment agent chamber with the rejuvenating device.

25. The device according to claim 23, wherein the first septum partially separates the treatment agent chamber from the delivery agent chamber.

26. The device according to claim 22, wherein the means for applying pressure comprises a plunger movably mounted within the main chamber.

27. The device according to claim 22, wherein the means for applying pressure comprises an expansible bellows disposed in the main chamber.

28. The device according to claim 22, wherein the means for applying pressure comprises a plastic sheet disposed in the main chamber.

29. The device according to claim 22, further comprising a semi-permeable membrane for permitting ingress of fluid from the body to the delivery agent chamber.

30. The device according to claim 24, wherein at least one of the first septum and the second septum is comprised of a self-sealing material.

31. The device according to claim 24, wherein at least one of the first and second septum is comprised of a material selected from the group consisting of polysiloxane elastomer, fluoroelastomer or composite elastomers of polyfluorosilicone.