Blood flow velocity measurement device

• US 5,799,350 A
• Filed: 02/27/1997
• Issued: 09/01/1998
• Est. Priority Date: 03/30/1994
• Status: Expired due to Fees

• Current Assignee: Pacesetter AB
• Original Assignee: Pacesetter AB
• Inventors: Ferek-Petric, Bozidar, Breyer, Branko
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US08/718,406
• Time in Patent Office: 551 Days
• Field of Search: 600/465, 600/466, 600/467, 607/6, 607/9, 607/17, 607/19
• US Class Current: 607/17
• CPC Class Codes: A61B 5/026 Measuring blood flow A61B3/1233, A61B3/1241 take precedence
• CPC Class Codes: A61N 1/36514 controlled by a physiological quantity other than heart potential, e.g. blood pressure controlled by two or more physical parameters A61N1/36585
• CPC Class Codes: A61N 1/36571 controlled by blood flow rate, e.g. blood velocity or cardiac output

Abstract

An intracardiac blood flow velocity measurement device has a catheter adapted to be inserted through a blood vessel into the heart, at least two electrodes made of two different biocompatible materials mounted on the catheter at a detecting position which is located in a selected detecting area when the catheter is inserted into the heart for detecting blood flow velocity, with at least one of the electrodes being formed as a polarizable electrode and being disposed in the detecting position, and another of the electrodes being located on the catheter at an axially spaced distance from the polarizable electrode. Variation in an over-voltage or in a galvanic voltage is detected, and is used as a blood flow velocity signal.

Claims

1. An intracardiac blood flow velocity measurement system comprising:

a catheter adapted for insertion into a heart through a blood vessel;

at least one blood flow velocity detecting means, mounted on said catheter, for detecting blood flow velocity at a detecting position in a selected detecting area when said catheter is inserted into said heart;

a plurality of electrical conductors contained in said catheter, each conductor having a distal end electrically connected to said blood flow velocity detecting means and each conductor having a proximal end;

electronic circuitry means, connected to the respective proximal ends of said electrical conductors, for receiving and processing blood flow velocity data generated by said blood flow velocity detecting means; and

said blood flow velocity detecting means comprising at least two electrodes respectively consisting of two different biocompatible materials, and at least a first of said at least two electrodes comprising a polarizable electrode and being disposed in said detecting position and a second of said at least two electrodes being disposed on said catheter axially spaced from said first electrode.

2. A system as claimed in claim 1 wherein said second electrode comprises a non-polarizable electrode.

3. A system as claimed in claim 2 wherein said non-polarizable electrode is mounted on said catheter at a position at which the blood flow velocity is less than blood flow velocity in said selected detecting area when said catheter is inserted into said heart.

4. A system as claimed in claim 1 wherein said second electrode comprises a polarizable electrode, and wherein said second electrode is mounted on said catheter at a position within said selected detecting area when said catheter is inserted into said heart.

5. A system as claimed in claim 1 further comprising a third electrode mounted on said catheter and connected to the distal end of one of said electrical conductors, said third electrode and said second electrode, in combination, comprising means for measuring an intracardiac electrocardiogram.

6. A system as claimed in claim 1 comprising a pacing electrode disposed at a distal end of said catheter and connected to one of said electrical conductors, and wherein said electronic circuitry means comprises means for generating a pacing control signal, dependent on said blood flow velocity data, and for supplying a pacing signal to said pacing electrode for pacing said heart dependent on said control signal.

7. A system as claimed in claim 6 wherein said pacing electrode comprises said second electrode.

8. A system as claimed in claim 6 wherein said at least two electrodes, in combination, generate an electrical signal containing said blood flow velocity data, and wherein said electronic circuitry means include filter means for extracting said blood flow velocity data from said electrical signal for use by said means for generating a control signal.

9. A system as claimed in claim 1 wherein said detecting area comprises an area of said heart in which the tricuspid valve is disposed.

10. A system as claimed in claim 1 wherein said detecting area comprises a cavity of the superior vena cava.

11. A system as claimed in claim 1 comprising a pacing electrode disposed at a distal end of said catheter and connected to one of said electrical conductors, and wherein said electronic circuitry means comprises means for generating a pacing control signal, dependent on said blood flow velocity data, and for supplying a pacing signal to said pacing electrode for pacing said heart dependent on said control signal, and wherein said second electrode comprises a polarizable electrode disposed within said selected detecting area when said catheter is inserted into the heart, and said first and second electrodes, in combination, forming a galvanic cell within the blood whose blood flow velocity is to be measured, and wherein said electrical conductors contained in said catheter comprise first and second electrical conductors respectively connected to said first and second electrodes, and a third electrical conductor connected to said pacing electrode.

12. A system as claimed in claim 11 wherein said galvanic cell formed by said first and second electrodes generates a galvanic voltage which varies throughout a cardiac cycle of said heart, and wherein said electronic circuitry means comprises means for evaluating said galvanic voltage as said blood flow velocity data.

13. A system as claimed in claim 12 wherein said first electrode is mounted on said catheter closer to said distal end of said catheter than said second electrode, said first electrode comprising an anode of said galvanic cell and said second electrode comprising a cathode of said galvanic cell, and wherein said galvanic voltage is positive at said anode relative to said cathode, said galvanic voltage thereby indicating a flow direction of said blood flow velocity from the cathode to the anode of said galvanic cell when said catheter is inserted into said heart.

14. A system as claimed in claim 13 wherein said detecting area comprises an area of said heart in which the tricuspid valve is disposed, and wherein said galvanic voltage includes a first peak indicative of diastolic filling caused by a ventricular relaxation in said heart and a second peak indicating an atrial filling caused by an atrial contraction in said heart, and wherein said electronic circuitry means comprises means for detecting said first and second peaks.

15. A system as claimed in claim 13 wherein said detecting area comprises a cavity of the superior vena cava, and wherein said galvanic voltage includes a first peak indicative of diastolic filling caused by a ventricular relaxation in said heart and a second peak indicating an atrial filling caused by an atrial contraction in said heart, and wherein said electronic circuitry means comprises means for detecting said first and second peaks.

16. A system as claimed in claim 11 further comprising a third electrode, said third electrode and one of said first and second electrodes comprising, in combination, bipolar sensing means for detecting a bipolar intracardiac electrocardiogram produced by cardiac muscle electrical activity, and wherein said electronic circuitry means comprises means for processing said intracardiac electrocardiogram, in combination with said galvanic voltage, for producing a signal indicative of said blood flow velocity.

17. A system as claimed in claim 16 wherein said first, second and third electrodes comprise a first pair of adjacent electrodes and a second pair of adjacent electrodes, the electrodes in said first pair of electrodes consisting of different material and the electrodes of said second pair of adjacent electrodes consisting of the same material.

18. A system as claimed in claim 17 wherein said second pair of adjacent electrodes comprise said galvanic cell, and wherein said second pair of adjacent electrodes detect said intracardiac electrocardiogram.

19. A system as claimed in claim 16 wherein said means for processing said galvanic voltage and said intracardiac electrocardiogram in combination comprise means for subtraction said intracardiac electrocardiogram from said galvanic voltage for producing said signal indicative of blood flow which is free of said cardiac muscle electrical activity.

20. A system as claimed in claim 16 wherein said electronic circuitry means include means for measuring an over-voltage at said first electrode and wherein said control means comprise means for controlling pacing of said heart dependent on said over-voltage.

21. A system as claimed in claim 20 wherein said electronic circuitry means comprise means for generating a blanking period for said means for measuring an over-voltage, dependent on said intracardiac electrocardiogram.

22. A system as claimed in claim 1 wherein said first electrode consists of a noble metal.