Pressure vessel access port

• US 5,799,830 A
• Filed: 11/08/1996
• Issued: 09/01/1998
• Est. Priority Date: 11/08/1996
• Status: Expired due to Term

• Current Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Hyclone Laboratories, Inc. (Danaher Corporation)
• Inventors: Carroll, David C., Brown, Dennis
• Primary Examiner(s): Derakshani, Philippe
• Application Number:
  US08/744,418
• Time in Patent Office: 662 Days
• Field of Search: 222/95, 222/105, 222/386.5, 222/389, 222/530
• US Class Current: 222/95
• CPC Class Codes: B67D 7/0255 squeezing collapsible or flexible storage containers for dispensing beverages on draught B67D1/0462
• CPC Class Codes: B67D 7/0288 Container connection means for dispensing beverages on draught B67D1/0829

Abstract

A disposable fluid transport system is provided for dispensing sterile fluids from a pressure vessel. The pressure vessel has an internal chamber with an outlet opening extending therethrough. The fluid transport system includes a collapsible media bag having an internal compartment defining a sterile environment. A first end of a delivery tube is attached in fluid communication to the compartment of the media bag. Disposed at a point along the length of a delivery tube is an interface adapter. The interface adapter includes an annular flange which encircles and radially projects out from the exterior surface of the delivery tube. The gasket is formed of a resiliently flexible material and has an outside diameter that is larger than the inside diameter of the outlet opening on the pressure vessel. Once the media bag and delivery tube are positioned within the chamber of the pressure vessel, the second end of the delivery tube can be fed out the outlet opening. As a result of the flexible nature of the gasket, the gasket can also be constricted to pass through the outlet opening and then radially expanded. A clamp can then be used to seal the gasket on the outlet opening so as to seal the outlet opening closed.

Claims

1. A fluid transport system for selectively dispensing a fluid from within a pressure vessel, the pressure vessel comprising a housing having an interior surface defining a chamber, the pressure vessel further comprising an outlet opening having an inner diameter and being formed on the housing and an inlet opening having an inner diameter and being formed on the housing, the inlet opening and the outlet opening each effecting discrete fluid communication between the chamber of the pressure vessel and the exterior of the pressure vessel, the fluid transport system comprising:

(a) a delivery tube comprising a first end, an opposing second end being sealed closed, an exterior surface, and an interior surface defining a lumen extending between the first end and the second end;

(b) containment means attached in sealed fluid communication with the first end of the delivery tube for forming a closed sterile environment capable of receiving and containing a fluid and for dispensing the contained fluid through the delivery tube when pressure is applied to the containment means; and

(c) first sealing means disposed at a point along the delivery tube for effecting a pressure tight seal of the outlet opening without breaching the closed sterile environment of the containment means to enable pressurization of the chamber of the pressure vessel when the containment means is positioned within the chamber and the second end of the delivery tube is passed from within the chamber though the outlet opening so as to be outside of the pressure vessel.

2. A fluid transport system as recited in claim 1, wherein the sealing means comprises a gasket encircling and radially extending out from the exterior surface of the delivery tube, the gasket extending to an outside perimeter that is larger than the inner diameter of the fluid outlet opening, the gasket being sufficiently flexible to pass through the outlet opening.

3. A fluid transport system as recited in claim 2, wherein the gasket is integrally formed with the delivery tube.

4. A fluid transport system as recited in claim 2, wherein the gasket is secured to the exterior surface of the delivery tube.

5. A fluid transport system as recited in claim 2, wherein the gasket has a first side with an annular ridge projecting therefrom and encircling the delivery tube.

6. A fluid transport system as recited in claim 5, wherein the gasket has a second side with an annular ridge projecting therefrom and encircling the delivery tube.

7. A fluid transport system as recited in claim 1, wherein the sealing means comprises:

(a) a tubular sleeve having an exterior surface and being fluid coupled in axial alignment with the delivery tube at a point between the first end and the second end of the delivery tube; and

(b) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket extending to an outside perimeter that is larger than the inner diameter of the outlet opening, the gasket being sufficiently flexible to pass through the outlet opening.

8. A fluid transport system as recited in claim 7, wherein the gasket has a first side with an annular ridge projecting therefrom and encircling the delivery tube.

9. A fluid transport system as recited in claim 1, wherein the containment means comprises a collapsible media bag having an interior surface defining a compartment for containing a fluid.

10. A fluid transport system as recited in claim 9, wherein the media bag comprises a plurality of liners.

11. A fluid transport system as recited in claim 9, further comprising a dip tube having:

(a) the first end disposed within a collapsible media bag; and

(b) a second end in sealed fluid communication with the first end of the delivery tube.

12. A fluid transport system as recited in claim 11, wherein the media bag has a bottom end and the fluid transport system further includes anchoring means for securing the first end of the delivery tube to the bottom end of the media bag to enable fluid to enter the first end of the dip tube thereat.

13. A fluid transport system as recited in claim 12, wherein the anchoring means comprises:

(a) a mounting plate having a top surface and a bottom surface, the bottom surface being secured to the bottom end of the media bag;

(b) a spout projecting from the top surface of the mounting plate to an attachment end, the spout also having an interior surface defining a passageway extending from the attachment end to the mounting plate; and

(c) a side port extending through the spout so as to be in fluid communication with the passageway of the spout when the attachment end is fluid coupled to the first end of the dip tube.

14. A fluid transport system as recited in claim 1, wherein the delivery tube is flexible.

15. A fluid transport system as recited in claim 1, further comprising:

(a) a supply tube comprising a first end attached in sealed fluid communication with the closed sterile environment of the containment means, an opposing second end being sealed closed, and an interior surface defining a lumen extending between the first end and the second end; and

(b) second sealing means disposed at a point along the supply tube for effecting a pressure tight seal of the inlet opening without breaching the closed sterile environment of the containment means to enable pressurization of the chamber of the pressure vessel when the containment means is positioned within the chamber and the second end of the supply tube is passed from within the chamber though the inlet opening so as to be outside of the pressure vessel.

16. A fluid transport system as recited in claim 12, wherein the second sealing means comprises:

(a) a tubular sleeve having an exterior surface and being fluid coupled in axial alignment with the supply tube at a point between the first end and the second end of the supply tube; and

(b) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket extending to an outside perimeter that is larger than the inner diameter of the inlet port, the gasket being sufficiently flexible to pass through the inlet opening.

17. A fluid transport system for selectively dispensing a fluid from within a pressure vessel, the pressure vessel comprising a housing having an interior surface defining a chamber, the pressure vessel further comprising an outlet opening having an inner diameter and being formed on the housing and an inlet opening having an inner diameter and being formed on the housing, the inlet opening and the outlet opening each effecting discrete fluid communication between the chamber of the pressure vessel and the exterior of the pressure vessel, the fluid transport system comprising:

(a) a collapsible media bag having an interior surface defining a compartment for containing a fluid;

(b) a delivery tube comprising;

(i) a first end in sealed fluid communication with the compartment of the media bag;

(ii) an opposing free second end being sealed closed; and

(iii) an interior surface defining a lumen extending between the first end and the second end, the lumen of the delivery tube and the chamber of the media bag comprising a closed sterile environment; and

(c) first sealing means disposed at a point along the delivery tube for effecting a pressure tight seal of the outlet opening without breaching the closed sterile environment to enable pressurization of the chamber of the pressure vessel when the media bag is positioned within the chamber and the second end of the delivery tube is passed from within the chamber though the outlet opening so as to be outside of the pressure vessel.

18. A fluid transport system as recited in claim 17, wherein the first sealing means comprises a gasket encircling and radially extending out from the exterior surface of the delivery tube, the gasket extending to an outside perimeter that is larger than the inner diameter of the outlet opening, the gasket being sufficiently flexible to pass through the outlet opening.

19. A fluid transport system as recited in claim 18, wherein the gasket has a first side with an annular ridge projecting therefrom and encircling the delivery tube.

20. A fluid transport system as recited in claim 17, wherein the first sealing means comprises:

(a) a tubular sleeve having an exterior surface and being fluid coupled in axial alignment with the delivery tube at a point between the first end and the second end of the delivery tube; and

(b) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket extending to an outside perimeter that is larger than the inner diameter of the outlet opening, the gasket being sufficiently flexible to pass through the outlet opening.

21. A fluid transport system as recited in claim 20, wherein the gasket has a first side with an annular ridge projecting therefrom and encircling the delivery tube.

22. A fluid transport system as recited in claim 17, further comprising:

(a) a supply tube comprising a first end attached in sealed fluid communication with the media bag, an opposing second end being sealed closed, and an interior surface defining a lumen extending between the first end and the second end, the lumen of the delivery tube, the lumen of the supply tube, and the chamber of the media bag comprising the closed sterile environment; and

(b) second sealing means disposed at a point along the supply tube for effecting a pressure tight seal of the inlet opening without breaching the closed sterile environment to enable pressurization of the chamber of the pressure vessel when the media bag is positioned within the chamber of the pressure vessel and the second end of the supply tube is passed from within the chamber though the inlet opening so as to be outside of the pressure vessel.

23. A fluid transport system as recited in claim 22, wherein the second sealing means comprises:

(a) a tubular sleeve having an exterior surface and being fluid coupled in axial alignment with the supply tube at a point between the first end and the second end of the supply tube; and

(b) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket extending to an outside perimeter that is larger than the inner diameter of the inlet port, the gasket being sufficiently flexible to pass through the inlet opening.

24. A fluid transport system for selectively dispensing a fluid from within a pressure vessel, the pressure vessel comprising a housing having an interior surface defining a chamber, a first sealing flange and a second sealing flange are formed on the housing of the pressure vessel, an outlet opening having an inner diameter extends through the first sealing flange so as to be in fluid communication with the chamber of the pressure vessel, likewise, an inlet opening having an inner diameter extends through the second sealing flange so as to be in fluid communication with the chamber of the pressure vessel, the fluid transport system comprising:

(a) a collapsible media bag having an interior surface defining a compartment for containing a fluid;

(b) a delivery tube having a lumen longitudinally extending therethrough, the delivery tube comprising;

(i) a transition tube having a first end in sealed fluid communication with the media bag and an opposing second end; and

(ii) a feeding tube having a first end and an opposing second end, the second end being sealed closed;

(c) a first interface adapter comprising;

(i) a tubular sleeve having a first end, an opposing second end, and an exterior surface extending therebetween, the tubular sleeve also having an interior surface defining a passageway extending between the first end and the second end, the first end of the tubular sleeve being fluid coupled with the second end of the transition tube, the second end of the tubular sleeve being fluid coupled with the first end of the feeding tube; and

(ii) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket extending to an outside perimeter that is larger than the inner diameter of the outlet opening extending through the first sealing flange, the gasket being sufficiently flexible that the interface adapter positioned within the chamber can be constricted to pass through the outlet opening in the first sealing flange and then expanded to enable the gasket to be mounted flush against the first sealing flange on the housing.

25. A fluid transport system as recited in claim 24, wherein the gasket has a first side with an annular ridge projecting therefrom and encircling the delivery tube.

26. A fluid transport system as recited in claim 25, wherein the gasket has a second side with an annular ridge projecting therefrom and encircling the delivery tube.

27. A fluid transport system as recited in claim 24, further comprising a first barbed adapter having a first end, a second end, and an interior surface defining a path extending therebetween, the first end of the first barbed adapter being received within the second end of the transition tube, the second end of the first barbed adapter being received within the first end of the tubular sleeve of the interface adapter.

28. A fluid transport system as recited in claim 27, wherein the first barbed adapter further comprises an exterior surface having an annular barb encircling and radially projecting from the exterior surface of the first end and the second end.

29. A fluid transport system as recited in claim 24, further comprising a second barbed adapter having a first end, a second end, and an interior surface defining a path extending therebetween, the first end of the second barbed adapter being received within the second end of the tubular sleeve of the interface adapter and the second end of the second barbed adapter being received within the first end of the feeding tube.

30. A fluid transport system as recited in claim 29, wherein the second barbed adapter further comprises an exterior surface having an annular barb encircling and radially projecting from the exterior surface of the first end and the second end.

31. A fluid transport system as recited in claim 24, further comprising:

(a) a supply tube having a lumen longitudinally extending therethrough, the supply tube comprising;

(i) a transaction tube having a first end fluid coupled with the compartment of the media bag and an opposing second end positioned outside of the media bag; and

(ii) a source tube having a first end and an opposing second end, the second end being sealed closed;

(b) a second interface adapter comprising;

(i) a tubular sleeve having a first end, an opposing second end, and an exterior surface extending therebetween, the tubular sleeve also having an interior surface defining a passageway extending between the first end and the second end, the first end of the tubular sleeve being fluid coupled with the transition tube, the second end of the tubular sleeve being fluid coupled with the first end of the source tube; and

(ii) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket extending to an outside perimeter that is larger than the inner diameter of the inlet opening extending through the second sealing flange, the gasket being sufficiently flexible that the second interface adapter positioned within the chamber can be constricted to pass through the inlet opening in the sealing flange and then expanded to enable the gasket to be mounted flush against the second sealing flange on the housing.

32. A fluid transport system as recited in claim 24, further comprising a dip tube having:

(a) the first end disposed within a collapsible media bag; and

(b) a second end in sealed fluid communication with the first end of the delivery tube.

33. A fluid transport system as recited in claim 32, wherein the media bag has a bottom end and the fluid transport system further includes anchoring means for securing the first end of the dip tube to the bottom end of the media bag to enable fluid to enter the first end of the dip tube thereat.

34. A fluid transport system as recited in claim 33, wherein the anchoring means comprises:

(a) a mounting plate having a top surface and a bottom surface, the bottom surface being secured to the bottom end of the media bag;

(b) a spout projecting from the top surface of the mounting plate to an attachment end, the spout also having an interior surface defining a passageway extending from the attachment end to the mounting plate; and

(c) a side port extending through the spout so as to be in fluid communication with the passageway of the spout when the attachment end is fluid coupled to the first end of the dip tube.

35. A fluid dispensing system comprising:

(a) a pressure vessel comprising a housing having an interior surface defining a chamber and an outlet opening formed on the housing to enable fluid communication between the chamber of the pressure vessel and the exterior of the pressure vessel;

(b) a delivery tube comprising a first end, an opposing second end being sealed closed, and an interior surface defining a lumen extending between the first end and the second end;

(c) containment means attached in sealed fluid communication with the first end of the delivery tube for forming a closed sterile environment capable of receiving and containing a fluid and for dispensing the contained fluid into the delivery tube when pressure is applied to the containment means;

(d) first sealing means disposed at a point along the delivery tube for effecting a pressure tight seal of the outlet opening without breaching the closed sterile environment of the containment means to enable pressurization of the chamber when the containment means is positioned within the chamber and the second end of the delivery tube is passed from within the chamber though the outlet opening so as to be outside of the pressure vessel; and

(e) first attachment means for removably securing the sealing means to the housing.

36. A fluid dispensing system as recited in claim 35, wherein the containment means comprises a collapsible media bag having an interior surface defining a compartment for containing a fluid.

37. A fluid dispensing system as recited in claim 35, wherein the sealing means comprises a gasket encircling and radially extending out from the exterior surface of the delivery tube, the gasket extending to an outside perimeter that is larger than the inner diameter of the outlet opening, the gasket being sufficiently flexible to pass through the outlet opening.

38. A fluid dispensing system as recited in claim 35, wherein the first sealing means comprises an interface adapter including:

(a) a tubular sleeve having an exterior surface and being fluid coupled in axial alignment with the delivery tube at a point between the first end and the second end of the delivery tube; and

(b) a gasket encircling and radially extending out from the exterior surface of the tubular sleeve, the gasket having a first side, a second side, and extending to an outside perimeter that is larger than the inner diameter of the outlet opening, the gasket being sufficiently flexible to pass through the outlet opening.

39. A fluid dispensing system as recited in claim 38, wherein the gasket has a first side with an annular ridge projecting therefrom and encircling the delivery tube.

40. A fluid dispensing system as recited in claim 38, wherein the attachment means comprises:

(a) a sealing flange formed on the exterior of the housing, the sealing flange having an exposed face with the outlet opening extending therethrough, the sealing flange being configured to engage the first side of the gasket when the interface adapter is passed through the outlet opening to the exterior of the housing; and

(b) a clamp configured to compress the first side of the gasket against the face of the sealing flange.

41. A fluid dispensing system as recited in claim 40, wherein the first attachment means further comprises a compression plate biased against the second face of the gasket.

42. A fluid dispensing system as recited in claim 41, wherein the compression plate comprises a pair of C-shaped plates biased against the second face of the gasket so as to encircle the delivery tube.

43. A fluid dispensing system as recited in claim 35, further comprising:

(a) an inlet opening formed on the housing of the pressure vessel to enable fluid communication between the chamber of the pressure vessel and the exterior of the pressure vessel;

(b) a supply tube comprising a first end attached in sealed fluid communication with the sterile environment of the containment means, an opposing second end being sealed closed, and an interior surface defining a lumen extending between the first end and the second end;

(c) second sealing means disposed at a point along the supply tube for effecting a pressure tight seal of the inlet opening without breaching the closed sterile environment of the containment means to enable pressurization of the chamber of the pressure vessel when the containment means is positioned within the chamber and the second end of the supply tube is passed from within the chamber though the inlet opening so as to be outside of the pressure vessel; and

(d) second attachment means for removably securing the second sealing means to the housing.

44. A fluid dispensing system comprising:

(a) a pressure vessel comprising a housing having an exterior surface, the housing also having an interior surface defining a chamber located within the pressure vessel, the pressure vessel further comprising;

(i) a sealing flange mounted on the exterior surface of the housing and having an exposed face;

(ii) an outlet opening with an inner diameter extending through the face of the sealing flange so as to be in fluid communication with the chamber of the pressure vessel;

(b) a collapsible media bag having an interior surface defining a compartment for containing a fluid, the media bag being configured to be received within the chamber of the pressure vessel;

(c) a flexible delivery tube having a first end in sealed fluid communication with the compartment of the media bag and an opposing second end, the delivery tube also being configured to be received within the chamber of the pressure vessel;

(d) an interface adapter comprising;

(i) a tubular member having a first end, an opposing second end, and an exterior surface extending between, the tubular member also having an interior surface defining a passageway extending between the first end and the second end, the tubular member being fluid coupled in axial alignment with the delivery tube at a point between the first end and the second end of the delivery tube; and

(ii) a gasket encircling and radially extending out from the exterior surface of the tubular member, the gasket having a first side, a second side, and extending to an outside perimeter that is larger than the inner diameter of the outlet opening extending through the sealing flange, the gasket being sufficiently flexible that when the second end of the delivery tube is passed from within the chamber through the outlet opening, the interface adapter can be constricted to also pass through the outlet opening in the sealing flange and then expanded to enable the gasket to be mounted flush against the face of the sealing flange; and

(e) clamping means for compressing the interface adapter against the face of the sealing flange to produce a pressure tight seal therebetween.

45. A fluid dispensing system as recited in claim 44, wherein the pressure vessel further comprises a selectively sealable entree port formed on the housing of the pressure vessel to communicate with the chamber, the entree port being configured to enable the media bag and delivery tube attached thereto to be received within the chamber of the pressure vessel.

46. A fluid dispensing system as recited in claim 44, wherein the pressure vessel further comprises a pressure supply line extending through the housing and communicating with the chamber for pressurizing the chamber.

47. A fluid dispensing system as recited in claim 44, further comprising:

(a) an annular ridge projecting from the first side of the gasket and encircling the tubular member; and

(b) an annular groove formed on the face of the sealing flange so as to encircle the outlet opening, the annular groove being configured to receive the annular ridge on the first side of the gasket.

48. A fluid dispensing system as recited in claim 44, further comprising a compression plate having a first side and a second side, the compression plate being configured to be biased against the second face of the gasket so as to encircle the tubular member.

49. A fluid dispensing system as recited in claim 48, further comprising:

(a) an annular ridge projecting from the second side of the gasket and encircling the tubular member;

(b) an annular groove formed on the first side of the compression plate, the annular groove on the compression plate being configured to receive the annular ridge on the second side of the gasket.

50. A fluid dispensing system as recited in claim 48, wherein the compression plate comprises a pair of C-shaped plates.

51. A fluid dispensing system as recited in claim 44, further comprising:

(a) a second sealing flange mounted on the exterior surface of the housing and having an exposed face;

(b) an inlet opening with an inner diameter extending through the face of the second sealing flange so as to be in fluid communication with the chamber of the pressure vessel;

(c) a flexible supply tube having a first end in sealed fluid communication with the compartment of the media bag, the supply tube also having an opposing second end;

(d) a second interface adapter comprising;

(i) a tubular member having a first end, an opposing second end, and an exterior surface extending between, the tubular member also having an interior surface defining a passageway extending between the first end and the second end, the tubular member being fluid coupled in axial alignment with the supply tube at a point between the first end and the second end of the supply tube; and

(ii) a gasket encircling and radially extending out from the exterior surface of the tubular member, the gasket having a first side, a second side, and extending to an outside perimeter that is larger than the inner diameter of the inlet opening extending through the second sealing flange, the gasket being sufficiently flexible that the second interface adapter positioned within the chamber can be constricted to pass through the inlet opening in the second sealing flange and then expanded to enable the gasket to be mounted flush against the face of the second sealing flange; and

(e) clamping means for compressing the second interface adapter against the face of the second sealing flange to produce a pressure tight seal therebetween.

52. A fluid dispensing system as recited in claim 44, further comprising a dip tube having a first end disposed within the compartment of the media bag and an opposing second end in fluid communication with the first end of the delivery tube.

53. A fluid dispensing system as recited in claim 52, further comprising an anchor, the anchor including:

(a) a mounting plate having a top surface and a bottom surface, the bottom surface being secured to the bottom end of the media bag;

(b) a spout projecting from the top surface of the mounting plate to an attachment end, the spout also having an interior surface defining a passageway extending from the attachment end to the mounting plate; and

(c) a side port extending through the spout so as to be in fluid communication with the passageway of the spout when the attachment end is fluid coupled to the first end of the dip tube.

54. A method for assembling a system for dispensing sterile fluid solutions, the method comprising the steps of:

(a) obtaining a pressure vessel comprising a housing having an exterior surface, the housing also having an interior surface defining a chamber located within the pressure vessel, the pressure vessel further comprising;

(i) an access door removably sealing an entree port, the entree port extending through the housing and communicating with the chamber;

(ii) an inlet opening extending through the housing and communicating with the chamber to selectively pressurize the chamber; and

(iii) an sealing flange formed on the exterior surface of the housing of the pressure vessel, the sealing flange having a outlet opening extending therethrough so as to be in fluid communication with the chamber of the pressure vessel;

(b) positioning a fluid transport system within the chamber of the pressure vessel through the entree port, the transport system comprising;

(i) a collapsible media bag having an interior surface defining a closed compartment for containing a fluid;

(ii) a flexible delivery tube having a first end in sealed fluid communication with the compartment of the media bag, the delivery tube also having an opposing second end being sealed closed; and

(iii) a flexible interface adapter comprising;

(A) a tubular member having a first end, an opposing second end, and an exterior surface extending between, the tubular member also having an interior surface defining a passageway extending between the first end and the second end, the tubular member being fluid coupled in axial alignment with the delivery tube at a point between the first end and the second end of the delivery tube; and

(B) a gasket encircling and radially extending out from the exterior surface of the tubular member, the gasket extending to an outside perimeter that is larger than the inner diameter of the outlet opening extending through the sealing flange, the gasket being sufficiently flexible to pass from within the chamber through the outlet opening in the sealing flange;

(c) passing the second end of the delivery tube including the interface adapter through the outlet opening so that the gasket is positioned flush against the sealing flange outside of the chamber; and

(d) sealing the gasket against the surface of the sealing flange so that the outlet opening is sealed closed, thereby enabling pressurization of the chamber having the media bag contained therein.