ROC method for early detection of disease
First Claim
1. A method of assessing the risk of an individual for a disease, comprising:
- a) testing the individual to detect a level of a marker for the disease;
b) computing risk of disease from a detected level of the marker; and
c) comparing the computed risk to thresholds to triage the individual into one of normal, borderline and elevated risk groups,wherein if the individual is triaged to a borderline risk group, the step of testing the individual to detect the level of the marker is repeated at a retest interval substantially less than a routine screening interval.
4 Assignments
0 Petitions
Accused Products
Abstract
A method of assessing risk of an individual for a disease is disclosed. A level of a marker for the disease is detected, and the risk of disease is computed from a statistical analysis of the marker level distributions for tested normal and diseased populations, using multivariate distributions. The computed risk is compared to thresholds to triage the individual into a normal, borderline, or elevated risk group, and a course of action based on the risk group is determined. Memory storing a program for execution on a data processing system, as well as a computer system comprising said memory is also disclosed, the memory comprising a receiver for signals representative of levels of a marker for the disease; a central procesing unit for computing risk of disease from one or more levels of the marker, and for comparing the computed risk to thresholds to triage the individual; and storage medium for the marker levels for subsequent computations of risk of disease.
-
Citations
31 Claims
-
1. A method of assessing the risk of an individual for a disease, comprising:
-
a) testing the individual to detect a level of a marker for the disease; b) computing risk of disease from a detected level of the marker; and c) comparing the computed risk to thresholds to triage the individual into one of normal, borderline and elevated risk groups, wherein if the individual is triaged to a borderline risk group, the step of testing the individual to detect the level of the marker is repeated at a retest interval substantially less than a routine screening interval. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
-
-
20. A method of assessing the risk of a woman for ovarian cancer, comprising:
-
a) testing the woman to detect a level of a marker for ovarian cancer; b) computing risk of ovarian cancer from a detected level of the marker; and c) comparing the computed risk to thresholds to triage the woman into one of normal, borderline and elevated risk groups, wherein if the woman is triaged to a borderline risk group, the step of testing the woman to detect the level of the marker is repeated at a retest interval substantially less than a routine screening interval. - View Dependent Claims (21, 22, 23, 24, 25)
-
-
26. A method of assessing the risk of an individual for a ovarian cancer comprising;
-
testing the individual at plural times to detect a level of a marker to the disease; computing risk of ovarian cancer from a statistical analysis of detected marker levels relative to multivariate marker level distributions for tested normal and diseased populations; and determining a course of action for the individual based on the computed risk factor. - View Dependent Claims (27, 28, 29, 30, 31)
-
Specification