Non-invasive estimation of arterial blood gases

• US 5,800,361 A
• Filed: 01/26/1996
• Issued: 09/01/1998
• Est. Priority Date: 02/06/1995
• Status: Expired due to Term

• Current Assignee: RIC INVESTMENTS LLC (Respironics Incorporated)
• Original Assignee: NTC Technology, Inc. (Dixtal Medical, Inc.)
• Inventors: Rayburn, Daniel B.
• Primary Examiner(s): Bahr, Jennifer
• Assistant Examiner(s): HUANG, STEPHEN D
• Application Number:
  US08/592,726
• Time in Patent Office: 949 Days
• Field of Search: 128/716, 128/719, 128/725, 128/726, 128/730, 128/204, 600/529, 600/532, 600/538, 600/539, 600/543
• US Class Current: 600/532
• CPC Class Codes: A61B 5/0836 Measuring rate of CO2 production
• CPC Class Codes: A61B 5/412 Detecting or monitoring sepsis

Abstract

A non-invasive system and procedure for deriving the blood gas content for a patient. The system measures the carbon dioxide concentration of the expiratory breath relative to volume. This data is then processed to derive arterial blood gas levels of carbon dioxide. If data sampling is in the time domain, the processing shifts the data from the time domain to the volume domain. The processing also iteratively assesses the significance of numerous variables. The resulting relationship provides a fast and accurate measure of blood gas content for both healthy and diseased lung patients.

Claims

1. A non-invasive arterial gas partial pressure determination system, comprising:

expiratory gas sampling means for taking one or more samples of expiratory gases from a patient;

means for assessing said gas partial pressure with respect to expiratory volume for said sampled gas;

means for evaluating said sampled gas in terms of said assessed gas partial pressure and expiratory volume iteratively during an exhale cycle to develop a multi-variable relationship; and

gas sampling data processing means for receiving data input representative of said multi-variable relationship and selectively processing said data input to determine at least one arterial gas partial pressure value for that patient.

2. The system of claim 1, wherein said multi-variable relationship is developed in a time domain, further comprising means for converting said multi-variable relationship from the time domain to a volume domain.

3. The system of claim 1, and further comprising memory means for storing a matrix of linear arguments recallable to form a vector for use by said data processing means in conjunction with said multi-variable relationship to determine a partial pressure for arterial CO₂.

4. A computer controlled data collection and processing method for monitoring arterial gas values for at least one gas, comprising:

sampling a patient'"'"'s exhaled breath to determine a partial pressure of said at least one gas in said exhaled breath as a function of incremental breath volume during an exhale cycle;

segregating data from said functional determination into three distinct phases representative of gas concentration of said at least one gas during said exhale cycle;

extracting functional variables from at least two of said three distinct phases in terms of slope and intercept values;

recalling from memory a matrix of weighting parameters associated with said extracted functional variables;

creating a vector based on said extracted functional variables modified by said recalled weighting parameters; and

determining an arterial gas value for said at least one gas based on said vector.

5. The method of claim 4, and further comprising calculating said matrix of weighting parameters by an artificial intelligence regimen assigning weight to individual variables based on adduced significance.

6. The method of claim 5, and further comprising sampling said exhaled breath at a frequency approximately between 10 and 1000 Hz.

7. The method of claim 6, and further comprising eliminating extreme calculated arterial gas values, statistically qualifying an average of multiple calculated preliminary arterial gas values, and determining the arterial gas value for said at least one gas.

8. The method of claim 7, and sampling said patient'"'"'s exhaled breath at intervals corresponding to requirements of the patient.

9. A system for deriving blood gas concentration for a patient for at least one gas, comprising:

a) data acquisition means for measuring exhaled breath from said patient and determining concentration of at least one gas fraction thereof at volumetric increments of said exhaled breath; and

b) data processing means for receiving data representative of said at least one determined concentration and extracting select parameters therefrom to form a relationship, and implementing said relationship to derive said blood gas concentration for said at least one gas.

10. The system of claim 9, and further comprising means for expressing the derived blood gas concentration as a partial pressure.

11. The system of claim 10 wherein said at least one gas is CO₂.

12. The system of claim 9 wherein said data processing means further includes a memory means for storing a matrix of weighting values to be applied to said relationship.

13. The system of claim 12 wherein said weighting values are calculated by iterative assessment of predictive gas concentrations compared to actual gas concentrations for said at least one gas.

14. A non-invasive method of determining blood gas content based on volume domain, comprising:

a) taking time domain measurements of a plurality of a patient'"'"'s expiratory breath during at least one respiratory cycle using a pneumotachometer, and a gas sensor for sensing the concentration of said blood gas in said breath, said measurements being at a frequency approximately between 10 and 1000 Hz;

b) converting said time domain measurements to the volume domain;

c) mapping said volume domain data to form a curve;

d) determining a threshold point having a value for said concentration of said blood gas in said breath, whereat said curve transcends from a value below said threshold point value to a value above said threshold point value;

e) calculating a first phase slope for said curve wherein said threshold point is an initial phase point, plotting subsequent points until said points deviate from a linear path, said deviation indicating the termination of said first phase;

f) calculating a second phase slope for said curve by taking a last data point of expiration during said at least one respiratory cycle and regressing toward the termination point of said first phase;

g) extracting first phase and second phase slope values to create an expiratory relationship;

h) combining said expiratory relationship with stored arguments into at least one vector;

i) using said at least one vector to produce an estimate of the concentration of said blood gas in said blood; and

j) visually displaying said gas content in said blood.

15. The method of claim 14 wherein said gas is CO₂.

16. The method of claim 15 wherein said threshold paint value is about 0.5% concentration of said blood gas.

17. The method of claim 15, and further determining a partial pressure of CO₂.

18. A non-invasive method of determining a dissolved gas content of an arterial portion of a patient'"'"'s pulmonary vasculature expressed as a partial pressure comprising:

a) taking time domain measurements of a plurality of said patient'"'"'s expiratory breaths using a pneumotachometer and gas sensor, at a frequency of about 100 Hz;

b) converting said time domain measurements to a volume domain;

c) mapping a curvature relationship of gas partial pressure versus gas volume;

d) determining a threshold point, said threshold point being the point where said curvature relationship transcends from a value below 0.5% of said gas partial pressure to a value above 0.5%;

e) calculating a first phase slope wherein said threshold point is an initial point and including plotting subsequent points until said points deviate from a linear path, said deviation indicating termination of said first phase;

f) calculating a second phase slope by taking a last data point of expiration and regressing toward the termination point of said first phase;

g) using the first and second phase slopes to quantify an expiratory gas relationship;

h) combining said relationship with stored arguments into at least one vector;

i) using said at least one vector to estimate partial pressure of said dissolved gas; and

j) visually displaying said partial pressure of said dissolved gas.

19. The method of claim 18 wherein said dissolved gas is CO₂.