Initiator priming for improved adherence of gels to substrates

• US 5,800,373 A
• Filed: 03/23/1995
• Issued: 09/01/1998
• Est. Priority Date: 03/23/1995
• Status: Expired due to Term

• Current Assignee: Genzyme Corporation (Sanofi )
• Original Assignee: Focal PLLC
• Inventors: Melanson, David A., Sawhney, Amarpreet S., Levine, Marc Alan, Bromander, Thomas S., Spiridigliozzi, John C.
• Primary Examiner(s): Buiz, Michael Powell
• Assistant Examiner(s): SMITH, CHALIN A
• Application Number:
  US08/410,037
• Time in Patent Office: 1,258 Days
• Field of Search: 427/2.24, 427/22.5, 427/2.3, 424/422, 424/426, 424/443-445, 602/41, 602/42, 602/52, 602/58, 602/900, 602/904, 602/78.02-78.07, 604/19.2
• US Class Current: 602/52
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 17/085 with adhesive layer
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 24/0042 Materials resorbable by the body
• CPC Class Codes: A61L 24/046 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043 takes precedence
• CPC Class Codes: A61L 24/06 obtained by reactions only involving carbon-to-carbon unsaturated bonds A61L24/043, A61L24/046 take precedence
• CPC Class Codes: C08F 2/48 by ultraviolet or visible light
• CPC Class Codes: C08F 220/00 Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
• CPC Class Codes: C08F 265/04 on to polymers of esters
• CPC Class Codes: C08F 271/00 Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
• CPC Class Codes: C08F 283/00 Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
• CPC Class Codes: C08F 289/00 Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
• CPC Class Codes: C08F 290/06 Polymers provided for in subclass C08G
• CPC Class Codes: C08F 290/062 Polyethers
• CPC Class Codes: C08F 290/14 Polymers provided for in subclass C08G
• CPC Class Codes: C08F 291/00 Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 33/04 : Homopolymers or copolymers of esters C08L43/04 takes precedence
• CPC Class Codes: C08L 71/02 : Polyalkylene oxides
• CPC Class Codes: C09D 4/00 : Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
• CPC Class Codes: C09J 151/00 : Adhesives based on graft polymers in which the grafted component is obtained by reactions only involving carbon-to-carbon unsaturated bonds based on ABS polymers C09J155/02; Adhesives based on derivatives of such polymers
• CPC Class Codes: Y10S 602/90 : Method of making bandage structure
• CPC Class Codes: Y10S 602/904 : Film-forming bandage material

Abstract

An improved barrier or drug delivery system which is highly adherent to the surface to which it is applied is disclosed, along with methods for making for making the barrier. In the preferred embodiment, tissue is stained with a photoinitiator, then the polymer solution or gel having added thereto a defined amount of the same or a different photoinitator is applied to the tissue. On exposure to light, the resulting system polymerizes at the surface, giving excellent adherence, and also forms a gel in the rest of the applied volume. Thus a gel barrier of arbitrary thickness can be applied to a surface while maintaining high adherence at the interface. This process is referred to herein as "priming". The polymerizable barrier materials are highly useful for sealing tissue surfaces and junctions against leaks of fluids. In another embodiment, "priming" can be used to reliably adhere preformed barriers to tissue or other surfaces, or to adhere tissue surfaces to each other. A first surface and a barrier, or another surface, are prestained with initiator, and a thin layer of gellable monomer containing initiator is placed between them. Strong adhesion is obtained between the two surfaces on gelation of the monomer. In a similar fashion, tissue surfaces can be adhered to each other in repair of wounds and formation of anastomoses.

Claims

1. A process for reducing leakage of bodily fluids, including air, the process comprising:

priming an area of a tissue surface by applying a polymerization initiator to the area, and applying to the area a solution containing a biodegradable, biocompatible, polymerizable monomer in combination with an initiator; and

polymerizing the monomer to seal the area and to reduce leakage of the bodily fluids through the area, whereby the polymerization occurs in both an interfacial and bulk manner.

2. The process of claim 1 wherein the area is first primed with one or more initiators, and then the monomer solution is applied to the area to result in mixing of the initiator with the monomer in the solution.

3. The process of claim 1 wherein the surface is the surface of dura.

4. The process of claim 1, in which the body fluid is selected from blood, serum, air, urine, bowl contents, cerebrospinal fluid, tears, and mucus.

5. The process of claim 4, in which the fluid is air.

6. The process of claim 1, wherein the tissue surface is part of the respiratory tract.

7. The process of claim 6, in which the surface is a surface of the lung.

8. The process of claim 1 further comprising applying a pharmaceutically active material to the area.

9. The process of claim 8 wherein the pharmaceutically active material is applied in combination with one or both of the initiator and the monomer solution.

10. The process of claim 1, in which the polymer is photopolymerizable and the initiator is a photoinitiator.

11. The process of claim 10, in which the photoinitiator is an eosin.

12. The process of claim 1 wherein the surface is the surface of dura.