Analyte-controlled liquid delivery device and analyte monitor
First Claim
1. A liquid delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin at a rate sufficient to maintain levels of an analyte within a physiologically acceptable range, comprising:
- a housing having a lower surface for application to the skin of the subject;
means for holding the housing in position with the lower surface against the subject'"'"'s skin;
a drug reservoir within the housing;
a hollow delivery needle associated with the drug reservoir extending through the lower surface when the lower surface is in contact with the subject'"'"'s skin, having an inner end communicating with the drug reservoir and an outer end projecting outwards a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin;
means for actively discharging the drug from the reservoir to the subject'"'"'s skin via the needle;
means for intermittently detecting the concentration of an analyte in the subject plasma and for providing an electrical signal in accordance with the detected concentration, the concentration of said analyte being directly or indirectly related to the amount of drug required by the subject; and
means for receiving said electrical signal and for controlling the rate of active discharge of drug in response thereto.
1 Assignment
0 Petitions
Accused Products
Abstract
A liquid delivery device comprising a housing having a lower surface for application to the skin of a subject and having a reservoir and a gas generation chamber therein separated by a displaceable membrane. Gas generated by an electrolytic cell under the control of a microprocessor causes the gas generation chamber to expand and the reservoir to contract, thereby discharging a liquid drug, such as insulin, from the reservoir via a hollow delivery needle extending from the lower surface. The delivery needle and a sensor needle both extend from the lower surface a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin. The sensor needle has an enzymatic coating for the detection of an analyte, such as glucose in the subject'"'"'s plasma. The delivery needle is made of platinum-iridium, and a current passes between the needles and a potentiostat circuit according to the amount of glucose detected. A reference electrode (silver/silver chloride) which rests against the subject'"'"'s skin increases the accuracy of the glucose measurement. The current through the potentiostat circuit is measured by a voltmeter and a signal from the voltmeter is amplified and communicated to the microprocessor which determines the correct rate of delivery of the drug on the basis of the level of analyte detected in the subject'"'"'s plasma.
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Citations
53 Claims
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1. A liquid delivery device for delivering a liquid drug to a subject via the subject'"'"'s skin at a rate sufficient to maintain levels of an analyte within a physiologically acceptable range, comprising:
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a housing having a lower surface for application to the skin of the subject; means for holding the housing in position with the lower surface against the subject'"'"'s skin; a drug reservoir within the housing; a hollow delivery needle associated with the drug reservoir extending through the lower surface when the lower surface is in contact with the subject'"'"'s skin, having an inner end communicating with the drug reservoir and an outer end projecting outwards a sufficient distance so as to penetrate through the epidermis and into the dermis when the housing is pressed against the skin; means for actively discharging the drug from the reservoir to the subject'"'"'s skin via the needle; means for intermittently detecting the concentration of an analyte in the subject plasma and for providing an electrical signal in accordance with the detected concentration, the concentration of said analyte being directly or indirectly related to the amount of drug required by the subject; and means for receiving said electrical signal and for controlling the rate of active discharge of drug in response thereto. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53)
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Specification