Cardio-synchronous impedance measurement system for an implantable stimulation device

• US 5,800,467 A
• Filed: 12/13/1996
• Issued: 09/01/1998
• Est. Priority Date: 12/15/1995
• Status: Expired due to Term

• Current Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Original Assignee: Pacesetter Incorporated (Abbott Laboratories)
• Inventors: Florio, Joseph J., Bradley, Kerry, Bornzin, Gene A., Park, Euljoon
• Primary Examiner(s): Getzow, Scott M.
• Application Number:
  US08/766,641
• Time in Patent Office: 627 Days
• Field of Search: 607/17, 607/24, 607/23
• US Class Current: 607/17
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

In a pacing system, the pacing controller induces the leads to deliver an impedance measurement pulse to the right ventricle of the heart at at least a 15 ms interval during a window of time following detection of the R-wave or the delivery of a pacing pulse. The window of time corresponds to a period of ventricular ejection. The two or three measured impedance values are then used to determine an impedance slope that has a strong biological correlation to the contractility of the heart. The impedance slope is then used by the controller of the pacing system to adjust the delivery of pacing pulses for purposes such as maximizing contractility for a given AV delay, PV delay and pacing rate of pacing pulses.

Claims

1. An implantable electrical system for delivering therapeutic shocks to a heart of a patient, the system comprising:

a lead, which extends into a ventricle of the heart, adapted for delivering electrical pulses;

control means for selectively inducing the lead to deliver an impedance measurement excitation pulse and pacing pulses to the ventricle to regulate the function of the heart;

measuring means, in response to the delivered excitation pulse, for measuring at least two instantaneous impedance measurements in the heart, wherein the impedance measurement excitation pulses are delivered to the heart at at least two different times during a measurement window to determine a single slope, the window being selected to coincide with contraction of the ventricle;

means for determining an impedance slope based on the instantaneous impedance measurements, the impedance slope being indicative of contractility of the heart; and

means for regulating the heart function based on the impedance slope.

2. The system of claim 1, wherein the means for determining the impedance slope comprises:

means for determining the difference between the instantaneous impedance measurements at the at least two different times.

3. The system of claim 2, wherein the control means comprises:

means for inducing the lead to deliver the impedance measurement excitation pulse at approximately a 64 Hz sampling rate during the measurement window.

4. The system of claim 1, further comprising:

sensing means for sensing a ventricular contraction;

timing means for triggering the measurement window to occur approximately 50-150 milliseconds after a ventricular contraction, and for triggering a sampling interval for the at least two instantaneous impedance measurements to be at least 15 ms apart.

5. The system of claim 1, wherein the control means comprises:

means for adjusting the pacing pulses to optimize the pumping function of the heart based on the impedance slope.

6. The system of claim 5, wherein the adjusting means comprises:

means for adjusting at least one of AV delay or PV delay until the measured impedance slope is maximized.

7. The system of claim 5, wherein the adjusting means comprises:

means for adjusting at least pacing rate until the measured impedance slope is maximized.

8. The system of claim 7, further comprising:

sensing means for sensing cardiac signals and for providing the control means with a signal that is indicative of contractions of the heart;

wherein the control means includes means for defining the measurement window as a window of time synchronous with the contraction of the heart corresponding to a period of late rapid ventricular ejection and early reduced ventricular ejection.

9. The system of claim 8, wherein the control means comprises:

means for inducing the lead to deliver the at least two impedance measurement excitation pulses during the measurement window at an interval of approximately 15 milliseconds.

10. The system of claim 1, wherein:

the lead includes a ventricular tip and a ring electrode coupled to the control means so that the impedance measurement excitation pulse emanates from the ventricular ring electrode; and

the impedance measurement means includes means for measuring the impedance between the ventricular electrode tip and a case electrode.

11. A pacing system for delivering pacing pulses to a heart comprising:

one or more leads positioned within one or more chambers of the heart including the right ventricle; and

control means for selectively inducing the one or more leads to provide electrical pulses to the respective chamber of the heart, and for measuring an instantaneous impedance within the heart, wherein the control means induces the leads to provide a first type of electrical pulse for pacing purposes, and wherein the control means induces the leads to provide a second type of electrical pulse defined by a window which occurs during a contraction of the ventricle of the heart so that the instantaneous impedance within the heart can be measured by the control means at at least two instances within the window, wherein the control means uses the two measured instantaneous impedance values to determine an impedance slope that corresponds to the contractility of the ventricle of the heart, and wherein the control means includes means for altering the delivery of the first electrical pulse to the heart based on the impedance slope.

12. The system of claim 11, wherein:

the at least one lead includes a lead that is positioned within the right ventricle of the heart; and

the second electrical pulses are provided to the right ventricle of the heart so that the control means can obtain an impedance slope during contraction of the right ventricle that has a high correlation to the contractility of the right ventricle during ventricular ejection.

13. The system of claim 12, wherein:

the one or more leads also includes a lead that is positioned within the right ventricle of the heart; and

the control means uses the impedance slope to adjust at least one of an AV delay, a PV delay, or pacing rate during pacing to increase the volume of blood pumped by the heart during ventricular ejection.

14. The system of claim 12, wherein the control means comprises:

means for inducing the at least one lead to deliver the second type of electrical pulse to the heart during the window so that at least two separate impedance measurements are made during the window at least 15 milliseconds apart.

15. The system of claim 11, wherein the difference between the instantaneous impedance measurements at the at least two different times corresponds to the impedance slope.

16. The system of claim 15, wherein the control means comprises:

means for adjusting the pacing pulses based on the impedance slope to optimize the pumping function of the heart.

17. The system of claim 16, further comprising:

sensing means for sensing cardiac signals of the heart and for providing the control means with a signal that is indicative of contractions of the heart.

18. The system of claim 17, wherein the control means comprises:

means for defining the measurement window as a window of time occurring approximately 50-150 milliseconds after the sensing means provides a signal indicative of a contraction.

19. The system of claim 18, wherein:

the at least one lead includes a ventricular tip and ring electrode;

the impedance measurement excitation pulse emanates from the ventricular ring electrode; and

the impedance measurement means measures the instantaneous impedance between the ventricular electrode tip and a case electrode.

20. The system of claim 11, wherein the control means is comprised of:

sensing means for receiving signals from the one or more leads that are indicative of the function of the heart;

pulse generator means for generating the first and second electrical pulses to the heart;

impedance measurement means for measuring the instantaneous impedance in the ventricle of the heart in response to the pulse generator means generating the second type of electrical pulse; and

processing means, in response to signals from the sensing means and the impedance measurement means, for providing signals to the pulse generator means to provide the first and second type of electrical pulses to the heart.

21. An implantable system for providing therapeutic electrical pulses to the heart of a patient comprising:

delivery means for delivering electrical pulses to a ventricle of the heart;

control means for controlling the delivery of the electrical pulses to the ventricle of the heart, wherein the control means induces the delivery means to provide a first type of electrical pulse for therapeutic purposes and a second type of electrical pulse for impedance measurement purposes; and

means for adjusting the first electrical pulses to optimize hemodynamics by measuring at least two instantaneous impedance measurements during a window defined by contraction of the ventricle of the heart to determine a single impedance slope representative of the instantaneous impedance slope that corresponds to the contractility of the ventricle of the heart.

22. The system of claim 21, wherein the delivery means comprises:

at least one lead having a tip electrode that is positioned adjacent the inner wall of the right ventricle of the heart; and

a return electrode for electrical pulses provided to the heart.

23. The system of claim 22, wherein the control means comprises:

means for obtaining a measurement of the instantaneous impedance during ventricular ejection based on the impedance measured between the tip and the case electrode whenever the second electrical pulse is produced between the ring and case electrode.

24. The system of claim 23, further comprising:

sensing means for sensing contractions of the heart and for providing a signal to the control means; and

wherein the control means includes means for inducing the delivery means to deliver the second type of electrical pulses to the heart after sensing a ventricular contraction so that the second electrical pulses are provided during a period of ventricular ejection.

25. The system of claim 24, wherein the control means comprises:

means for inducing the delivery means to deliver the second type of electrical pulses at a rate of about 64 Hz during a window that is approximately 50-150 milliseconds following the sensing of either a naturally occurring contraction or an evoke contraction.

26. The system of claim 25, wherein the control means comprises:

means for determining the difference between the instantaneous impedance measurements corresponding to the impedance slope.

27. The system of claim 26, wherein the control means comprises:

means for adjusting the delivery of the first type of electrical pulse to the heart to increase the impedance slope.

28. A method of providing electrical pulses to the heart of a patient comprising the steps of:

sensing the occurrence of either an evoke contraction or a naturally occurring contraction;

providing two impedance measurement pulses to a ventricle of the heart during either the evoked contraction or the naturally occurring contraction;

obtaining two instantaneous impedance measurements in response to the two impedance measurement pulses;

determining an impedance slope based on the two instantaneous impedance measurements; and

adjusting the delivery of one or more pacing electrical pulses to the heart based upon the determined impedance slope.

29. The method of claim 28, wherein the step of providing two impedance measurement pulses to a ventricle comprises the step of:

providing two impedance measurement pulses to the right ventricle via a pacing lead having a tip and a ring electrode that is positioned within the right ventricle.

30. The method of claim 29, wherein the step of obtaining two impedance measurements during the window of time comprises the step of:

measuring the instantaneous impedance between a selected return electrode and the tip electrode.

31. The method of claim 30, wherein the step of determining an impedance slope comprises the step of:

determining the difference between the instantaneous impedance measurements at at least two different times.

32. The method of claim 31, wherein the step of providing the two impedance measurement pulses comprises the step of:

providing the two impedance measurement pulses at a rate of about 64 Hertz during a window of time occurring approximately 50-150 milliseconds following the sensing of either the evoke contraction or the naturally occurring contraction.

33. The method of claim 32, wherein the step of adjusting the delivery of one or more pacing electrical pulses to the heart based upon the determined impedance slope comprises the step of:

adjusting at least one of the pacing rate, the AV delay or the PV delay to increase the impedance slope for subsequent measurements.

34. An implantable electrical system for delivering therapeutic stimulation to a patient'"'"'s heart, the system comprising:

a lead, which extends into a ventricle of the heart, adapted for delivering electrical pulses;

a pulse generator, coupled to the lead, that selectively generates one of tissue stimulation pulses or impedance excitation pulses to the ventricle, wherein the impedance excitation pulses are delivered at two different times during a period of ventricular ejection corresponding to contraction of the ventricle;

an impedance measuring circuit, coupled to the lead, that measures an instantaneous impedance at the two different times the excitation pulses are delivered during the ventricular contraction;

a processor system, coupled to the impedance sensing circuit and the pulse generator, that determines an impedance slope based on the two instantaneous impedance measurements, the impedance slope being indicative of contractility of the ventricle, and that regulates the generation of the tissue stimulation pulses based on the impedance slope.