Method of controlling epilepsy by brain stimulation

• US 5,800,474 A
• Filed: 11/01/1996
• Issued: 09/01/1998
• Est. Priority Date: 11/01/1996
• Status: Expired due to Term

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Marescaux, Christian, Benabid, Alim L.
• Primary Examiner(s): Kamm, William E.
• Assistant Examiner(s): LAYNO, CARL HERNANDZ
• Application Number:
  US08/742,841
• Time in Patent Office: 669 Days
• Field of Search: 607/45, 607/46, 607/48, 607/58, 607/72
• US Class Current: 607/45
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36064 Epilepsy

Abstract

A method of preventing seizures as experienced by persons with Epilepsy. High frequency electrical stimulation pulses are supplied to the subthalamic nucleus thereby blocking neural activity in the subthalamic nucleus and reducing excitatory input to the substantia nigra which leads to a reduction in the occurrence of seizures.

Claims

1. A method of therapeutically treating epilepsy resulting in a reduction in the occurrence of seizures comprising the steps of:

surgically implanting an implantable electrode in the brain, the implantable electrode having a proximal end and a stimulation portion, the electrode being implanted in the brain so that the stimulation portion of the electrode lies in the subthalamic nucleus of the brain;

providing an electrical signal generator;

coupling said proximal end of said electrode to said signal generator; and

operating said signal generator at a predetermined stimulus repetition rate high enough to block activity of the subthalamic nucleus to reduce the excitatory input from the subthalamic nucleus to the substantia nigra there by reducing the occurrence of seizures.

2. A method, as claimed in claim 1, wherein said stimulus repetition rate is about 10-2500 Hz.