PTFE vascular graft

• US 5,800,512 A
• Filed: 01/22/1996
• Issued: 09/01/1998
• Est. Priority Date: 01/22/1996
• Status: Expired due to Term

• Current Assignee: Lifeport Sciences LLC (Acacia Research Corporation)
• Original Assignee: Meadox Medicals, Inc. (Boston Scientific Corporation)
• Inventors: Henderson, Jamie, Lentz, David J., Zdrahala, Richard J., Dormier, Edward J.
• Primary Examiner(s): BRITTINGHAM, DEBRA
• Application Number:
  US08/588,052
• Time in Patent Office: 953 Days
• Field of Search: 623/1, 623/11, 623/12, 600/36
• US Class Current: 623/1.1
• CPC Class Codes: A61F 2/06 Blood vessels
• CPC Class Codes: A61F 2002/0086 for preferentially controlling or promoting the growth of specific types of cells or tissues of bone tissue onto implantable joints A61F2002/3093
• CPC Class Codes: A61F 2002/072 Encapsulated stents, e.g. wire or whole stent embedded in lining
• CPC Class Codes: A61L 27/16 obtained by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/507 for artificial blood vessels apparatus for applying cells on a blood vessel prosthesis A61F2/062
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: C08L 27/18 Homopolymers or copolymers or tetrafluoroethene
• CPC Class Codes: Y10S 623/901 Method of manufacturing prosthetic device

Abstract

An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube.

Claims

1. An implantable tubular prosthesis comprising:

an expanded polytetrafluoroethylene (ePTFE) composite tubular structure including a clearly defined tissue contacting expanded outer tube and concentrically adjacent separately expanded inner tube, an inner surface of which is a blood contacting surface;

said outer and inner tubes each having a given porosity defined by node and fibril spacing of said expanded structure, said given porosity of said inner tube being different from said given porosity of said outer tube and wherein a distinct difference in porosity between said inner tube and said outer tube is defined on either side of an interface therebetween.

2. An implantable tubular prosthesis of claim 1 wherein said outer tube exhibits a radial strength in excess of the radial strength of said inner portion.

3. An implantable tubular prosthesis of claim 1 wherein said given porosity of said inner tube is greater than said given porosity of said outer tube.

4. An implantable polytetrafluoroethylene (PTFE) tubular vascular prosthesis comprising:

a first PTFE tubular structure having been expanded to provide a given radial strength; and

a second PTFE tubular structure circumferentially disposed externally about said first expanded PTFE tubular structure;

said first expanded PTFE tubular structure exhibiting a porosity sufficient to promote cell endothelization therealong and said second PTFE tubular structure exhibiting radial strength in excess of the radial strength of said first expanded PTFE tubular structure.

5. A vascular prosthesis of claim 4 wherein said second PTFE tubular structure is adheringly supported over said first PTFE tubular structure.

6. A vascular prosthesis of claim 4 further including an additional structure formed over one of said first PTFE tubular structure and over said second PTFE tubular structure.

7. A vascular prosthesis of claim 6 wherein said additional structure is interposed between said first PTFE tubular structure and said second PTFE tubular structure.

8. A vascular prosthesis of claim 7 wherein said additional structure exhibits a porosity which is less than said porosity of said first PTFE tubular structure.

9. A vascular prosthesis of claim 7 wherein said additional structure is formed of a polymer composition.

10. A vascular prosthesis of claim 9 wherein said polymer composition is PTFE.

11. A vascular prosthesis of claim 4 wherein said second PTFE structure is formed of expanded PTFE.

12. A vascular prosthesis of claim 10 wherein said first PTFE structure has a porosity greater than that of said second PTFE structure.

13. A vascular prosthesis of claim 12 wherein said additional structure exhibits a strength which is greater than the radial strength of said first PTFE structure.

14. A vascular prosthesis of claim 13 wherein said additional structure exhibits strength less than said strength of said second PTFE structure.