Microsampling device and method of construction
First Claim
Patent Images
1. A microsampler comprising:
- a wafer of material defining therein a microsampler chamber;
a needle formed integrally with and extending from said microsampler chamber; and
a vent channel communicating with said microsampler chamber.
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Abstract
A minimally intrusive and less painful, self-use microsampling device and method for the measurement of glucose and other analytes in blood are provided. The device of the invention may have one or two optical windows for measuring the concentration of an absorbent reaction product or no windows if methods other than optical absorbance is used. The sampling chamber of the device can contain analytical reagents and other additives to facilitate the sampling and analytical steps. Also provided is a fabrication method for the microsampling device.
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Citations
18 Claims
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1. A microsampler comprising:
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a wafer of material defining therein a microsampler chamber; a needle formed integrally with and extending from said microsampler chamber; and a vent channel communicating with said microsampler chamber. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of making a microsampler with two optical windows comprising:
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a. providing a silicon wafer having a top surface and a bottom surface; b. etching out first and second depressions in the bottom surface of said wafer; c. forming an optical window in the first and second depressions; d. etching a patterned depression in the top surface aligned with the optical window in the bottom surface of said wafer and defining therein a microsampler chamber, a needle bore, and a vent channel; e. covering said patterned depression in said top surface with a cover glass; f. etching out the needle by removing silicon and cover glass; and g. forming a point on the needle.
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17. A method of making a microsampler with one window comprising:
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a. providing a silicon wafer having a top surface and a bottom surface; b. etching a patterned depression in the top surface of said wafer and defining therein a microsampler chamber, a needle bore, and a vent channel; c. covering said patterned depression in said top surface with a cover glass; d. etching out the needle by removing silicon and cover glass; and e. forming a point on the needle.
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18. A method of making a microsampler comprising:
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a. providing a silicon wafer having a top surface and a bottom surface; b. etching a patterned depression in the top surface of said wafer and defining therein a microsampler chamber, a needle bore, and a vent channel; c. covering said patterned depression in said top surface with a cover of silicon material; d. etching out the needle by removing silicon and silicon cover; and e. forming a point on the needle.
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Specification