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Excipient stabilization of polypeptides treated with organic solvents

  • US 5,804,557 A
  • Filed: 09/24/1996
  • Issued: 09/08/1998
  • Est. Priority Date: 02/23/1993
  • Status: Expired due to Term
First Claim
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1. A method of increasing solubility of a polypeptide in an aqueous formulation comprising a polyol excipient, said method comprising:

  • admixing the polypeptide with the polyol excipient, wherein the polyol excipient is trehalose,wherein said increasing is at least 2-fold relative to solubility of the polypeptide in the formulation lacking excipient.

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