Excipient stabilization of polypeptides treated with organic solvents
First Claim
Patent Images
1. A method of increasing solubility of a polypeptide in an aqueous formulation comprising a polyol excipient, said method comprising:
- admixing the polypeptide with the polyol excipient, wherein the polyol excipient is trehalose,wherein said increasing is at least 2-fold relative to solubility of the polypeptide in the formulation lacking excipient.
0 Assignments
0 Petitions
Accused Products
Abstract
Methods and compositions for excipient stabilization of dry or aqueous polypeptides treated with organic solvents are disclosed, wherein the polypeptide is admixed with a polyol having a molecular weight less than about 70,000 kD.
-
Citations
8 Claims
-
1. A method of increasing solubility of a polypeptide in an aqueous formulation comprising a polyol excipient, said method comprising:
-
admixing the polypeptide with the polyol excipient, wherein the polyol excipient is trehalose, wherein said increasing is at least 2-fold relative to solubility of the polypeptide in the formulation lacking excipient. - View Dependent Claims (2, 3, 4)
-
-
5. A composition comprising a polypeptide admixed in an aqueous formulation with a polyol excipient, wherein the polyol excipient is trehalose,
wherein the solubility of the polypeptide in the formulation is increased by at least 2-fold relative to solubility of the polypeptide in the formulation lacking excipient.
Specification