Impedance spectroscopy system for ischemia monitoring and detection
First Claim
1. A method for detecting ischemia in tissue, comprising:
- applying electrical energy to the tissue;
detecting a spectral response of the tissue; and
applying a transformation to the spectral response to determine a measure of ischemia of the tissue.
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Abstract
An impedance spectroscopy tissue status monitoring and measurement system is disclosed. The system uses a synthesizer to generates electrical signals of selected frequencies. An electrical current source is responsive to the synthesizer and generates electrical currents for transmission through tissue. Electrodes or inductive coils of the system apply the electrical current to the tissue and sense voltages generated in the tissue in response to the electrical current. A controller determines the spectral response of the tissue by detecting magnitude and phase information of the electrical energy transmitted through the tissue. The information is then used to determine volumes of compartments within the tissue and ionic concentrations of compartmental fluids. Capacitive effects derived from the phase information are used to determine cell membrane functionality within the tissue. From this analysis, status, specifically, ischemia, may be determined on an absolute basis.
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Citations
31 Claims
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1. A method for detecting ischemia in tissue, comprising:
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applying electrical energy to the tissue; detecting a spectral response of the tissue; and applying a transformation to the spectral response to determine a measure of ischemia of the tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method for detecting a status of tissue, comprising:
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applying electrical energy to the tissue; detecting a spectral response of the tissue; and combining parameters derived from the detected spectral response of the tissue in a pattern matching algorithm that is trained to generate a measure of the status of the tissue from the parameters. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24)
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25. A system for detection of tissue ischemia, the system comprising:
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a synthesizer for generating electrical signals; an electrical current source, responsive to the synthesizer, for generating electrical energy for transmission through tissue in response to the electrical signals; means for applying the electrical energy from the current source to the tissue and for sensing voltages generated in the tissue in response to the electrical energy; and a controller for determining measures of the ischemia in the tissue in response to detected spectral responses of the tissue based on the sensed voltages. - View Dependent Claims (26, 27, 28, 29, 30)
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31. A system for monitoring status of tissue comprising:
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a synthesizer for generating electrical signals; an electrical current source, responsive to the synthesizer, for generating electrical energy for transmission through tissue in response to the electrical signals; means for applying the electrical energy from the current source to the tissue and for sensing voltages generated in the tissue in response to the electrical energy; and a controller that executes a pattern matching algorithm that is trained to generate a measure of the tissue'"'"'s status in response to parameters derived from a spectral response of the tissue from the sensed voltages.
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Specification