Polymer matrix drug delivery apparatus

• US 5,807,306 A
• Filed: 08/16/1994
• Issued: 09/15/1998
• Est. Priority Date: 11/09/1992
• Status: Expired due to Term

• Current Assignee: Vention Medical Advanced Components, Inc. (Nordson Corporation)
• Original Assignee: Cortrak Medical Incorporated
• Inventors: Shimada, Jin, Hildelbrand, Keith R., Knudson, Mark B., Shapland, J. Edward, Racchini, Joel R.
• Primary Examiner(s): MCDERMOTT, CORRINE MARIE
• Application Number:
  US08/291,394
• Time in Patent Office: 1,491 Days
• Field of Search: 604/20-22, 604/49, 604/52, 604/53, 604/96, 604/101, 604/265, 606/192, 606/194
• US Class Current: 604/21
• CPC Class Codes: A61M 2025/1013 with concentrically mounted balloons, e.g. being independently inflatable
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2210/167 Penis
• CPC Class Codes: A61M 25/104 used for angioplasty
• CPC Class Codes: A61M 37/0092 using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428

Abstract

A drug delivery apparatus and method for delivering a drug locally to internal body tissue using a catheter device including a polymer matrix containing a drug. The drug is actively transported from the polymer matrix to the internal body tissue using iontophoresis or phonophoresis. In addition, the polymer matrix can be expanded to promote intimate contact with the walls of a passageway or vessel.

Claims

1. An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising:

a catheter having an elongated body;

a polymer matrix operably connected to and coaxially aligned with the elongated body, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene oxide, polyacrylamide, polyurethane rubber, and natural rubber; and

transport means operably connected to the catheter, the transport means being configured to actively transport the drug from the polymer matrix to the internal body tissue.

2. The apparatus of claim 1 wherein the transport means comprises iontophoresis means.

3. The apparatus of claim 2 wherein the iontophoresis means comprises at least two electrodes configured to be placed in electrical communication with a power supply;

at least one of the electrodes being positioned for electrical communication with the polymer matrix.

4. The apparatus of claim 3 wherein the plurality of electrodes comprises first and second electrodes, the first and second electrodes being operably connected to the catheter.

5. The apparatus of claim 1 wherein the catheter is flexible.

6. The apparatus of claim 1 wherein the elongated body has a circumference and the polymer matrix circumscribes the circumference.

7. An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising:

a catheter having an elongated body;

a polymer matrix operably connected to the elongated body, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene polyetheline oxide, polyacrylamide, polyurethane rubber, and natural rubber;

expansion means operably connected to the elongated body, the expansion means being configured to expand the polymer matrix in a direction substantially radial to the catheter; and

transport means operably connected to the catheter, the transport means being configured to actively transport the drug from the polymer matrix to the internal body tissue.

8. The apparatus of claim 7 wherein the expansion means comprises a balloon.

9. An apparatus for delivering a drug to internal body tissue of a patient, the apparatus comprising:

a catheter having a balloon;

a polymer matrix operably connected to the balloon, the polymer matrix being substantially non-compressible and configured to embody the drug, the polymer matrix selected from the group consisting essentially of polyethylene oxide, polyacrylamide, polyurethane rubber, and natural rubber; and

first and second electrodes configured to be placed in electrical communication to a power supply, the first electrode being positioned for electrical communication with the polymer matrix.

10. The apparatus of claim 9 wherein the second electrode is operatively connected to the catheter.