Pumping and pressure detection using flexible tubes

• US 5,807,322 A
• Filed: 09/12/1996
• Issued: 09/15/1998
• Est. Priority Date: 03/21/1994
• Status: Expired due to Fees

• Current Assignee: Sims Graseby Limited (ICU Medical Incorporated)
• Original Assignee: Graseby Medical Limited (ICU Medical Incorporated)
• Inventors: Lindsey, Michael J., Coulson, David R.
• Primary Examiner(s): Buiz, Michael
• Assistant Examiner(s): MENDEZ, MANUEL A
• Application Number:
  US08/716,152
• Time in Patent Office: 733 Days
• Field of Search: 604/30, 604/31, 604/49, 604/50, 604/65-67, 604/118, 128/DIG. 12, 128/DIG. 13
• US Class Current: 604/65
• CPC Class Codes: A61M 5/16859 Evaluation of pressure response, e.g. to an applied pulse
• CPC Class Codes: A61M 5/365 Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: F04B 2205/03 Pressure in the compression chamber
• CPC Class Codes: F04B 2205/07 Pressure difference over the pump
• CPC Class Codes: F04B 43/082 the tubular flexible member being pressed against a wall by a number of elements, each having an alternating movement in a direction perpendicular to the axes of the tubular member and each having its own driving mechanism
• CPC Class Codes: G01N 7/00 Analysing materials by measuring the pressure or volume of a gas or vapour

Abstract

A peristaltic pump unit (18) has a flexible infusate line (28) which is repeatedly compressed by a flat plate like pusher (30). Transverse valve plates (32, 34), on either side of the pusher (30), operate sequentially to close the line in front of and behind the pusher. A resistive pressure sensor (50), between the two valves, provides signals to a microprocessor (46) which provides the system monitoring capabilities. Consistency in dose rate is provided by arranging for the flexible line (28) to be received in an elongate groove or channel (58) which acts to restrain sideways bulging of the line as it is being compressed by the pusher.

Claims

1. A peristaltic pump comprising a flexible line carrying fluid to be pumped, cyclical line compression means arranged repeatedly to compress the line, the pump having an input valve upstream of the line compression means and an output valve downstream of the line compression means, pressure sensing means arranged to provide a signal representative of the pressure in the line between the input and output valves, the said signal being supplied to pump monitoring means, and the monitoring means having indicator means arranged to provide a pump status indication;

characterised in that the pump monitoring means is arranged to monitor the compression pressure, when both the input and the output valves are closed and pressure is applied to the line by the line compression means.

2. A peristaltic pump as set out in claim 1 in which the monitoring means is arranged to monitor the input pressure, when the input valve is open and the output valve is closed.

3. A peristaltic pump as set out in claim 1 in which the monitoring means is arranged to monitor the output pressure, when the input valve is closed and the output valve is open.

4. A peristaltic pump as set out in claim 1 in which the pump monitoring means includes means for detecting whether a fluid supply is attached to the line.

5. A peristaltic pump as set out in claim 4 wherein the monitoring means is arranged to monitor the input pressure when the input valve is open and the output valve is closed, in which the means for detecting whether a fluid supply is attached to the line comprises means for determining whether the input pressure, or the mean input pressure, is higher than a reference value.

6. A peristaltic pump as set out in claim 1 in which the pump monitoring means includes means for detecting an occlusion downstream of the pump.

7. A peristaltic pump as set out in claim 6 wherein the monitoring means is arranged to monitor the output pressure when the input valve is closed and the output valve is open, in which the means for detecting an occlusion downstream of the pump comprises means for determining whether the output pressure, or the mean output pressure, is greater than a threshold value.

8. A peristaltic pump as set out in claim 1 in which the pump monitoring means includes means for detecting air in the line.

9. A peristaltic pump as set out in claim 8 in which the means for detecting air in the line comprises means for comparing the compression pressure with the input pressure, or for comparing the mean compression pressure with the mean input pressure.

10. A peristaltic pump as set out in claim 1 in which the pump monitoring means includes means for detecting an occlusion upstream of the pump.

11. A peristaltic pump as set out in claim 10 wherein the monitoring means is arranged to monitor the input pressure when the input valve is open and the output valve is closed, in which the means for detecting an occlusion upstream of the pump comprises means for detecting an input pressure decrease over several pump cycles.

12. A peristaltic pump as set out in claim 1 including a position sensor arranged to supply a synchronization signal to the pump monitoring means at each pump cycle.

13. A drug infusion unit incorporating a peristaltic pump comprising a flexible line carrying fluid to be pumped, cyclical line compression means arranged repeatedly to compress the line, the pump having an input valve upstream of the line compression means and an output valve downstream of the line compression means, pressure sensing means arranged to provide a signal representative of the pressure in the line between the input and output valves, the signal being supplied to pump monitoring means, and the monitoring means having indicator means arranged to provide a pump status indication;

characterized in that the pump monitor means is arranged to monitor the compression pressure, when both the input and the output valves are closed and pressure is applied to the line by the line compression means.

14. A drug infusion unit as set out in claim 13 in which the peristaltic pump is contained within a main body of the unit, the main body being arranged to cooperate with a disposable cassette containing a bag within which is the drug to be infused, the bag including a flexible supply line on which the pump is arranged to operate when the cassette is in place.

15. A drug infusion pump as set out in claim 14 in which the supply line is bent through a loop of substantially 180°

, with the input and output valves being adjacent to each other, one at each end of the loop, the compression means and the pressure sensing means being within the loop.

16. A drug infusion unit as set out in claim 15 in which there are two compression means within the loop, operating together to compress the line.

17. A drug infusion unit as set out in claim 16 in which the two compression means are adjacent to each other.

18. A drug infusion unit as set out in claim 13 in which the compression means, input valve, and output valve are all compression members, arranged to compress the line from the outside.

19. A drug infusion unit as set out in claim 18 in which the compression members compress the line against a fixed support which is part of the main body of the unit.

20. A drug infusion unit as set out in claim 18 in which the compression members operate by means of cams on a common camshaft.

21. A drug infusion unit as set out in claim 13 including a position sensor arranged to supply a synchronization signal to the pump monitoring means at each pump cycle.

24. A peristaltic pump as set out in claim 21 in which the support defines a groove in which the line is located, the sides of the groove acting to prevent or restrain the line from bulging.

25. A peristaltic pump as set out in claim 24 in which the width of the groove is substantially equal to the outer diameter of the line.

22. A peristaltic pump including a flexible line carrying fluid to be pumped, line compression means arranged repeatedly to compress the line, an input valve upstream of the line compression means and an output valve downstream of the line compression means;

the line compression means comprising a member which is arranged to compress the line against a support, the pump including restraining means preventing or restraining the line from bulging in a direction perpendicular to the compression direction.

23. A peristaltic pump as set out in claim 22 in which the member is an elongate plate, extending along the line, the thickness of the plate being less than the outer diameter of the line.

26. A contamination-in-line detector comprising a line through which in use a fluid flows, pressure means arranged to apply pressure to the fluid within the line between an input valve and an output valve, and pressure sensing means arranged to provide a signal representative of the pressure in the line between the input and output valves, characterised in that the line is flexible and the pressure means applies pressure to the fluid within the flexible line by compressing said line, the pressure sensing means providing the signal when both the valves are closed and pressure is being applied by the pressure means.

27. A detector as claimed in claim 26 in which the pressure sensing means is also arranged to provide a signal representative of the pressure in the line when either or both of the valves are open, or when both of the valves are closed but no pressure is being applied by the pressure means.

28. A detector as claimed in claim 26 in which comparison means is provided to compare the two pressures and thereby provide a determination of whether there is contamination in the line.

29. A detector as claimed in claim 26 in which calculation means is provided to produce an estimate of the amount of contamination.