Detection of cancerous lesions by their effect on the periodic modulation of perfusion in the surrounding tissues

• US 5,810,010 A
• Filed: 01/03/1995
• Issued: 09/22/1998
• Est. Priority Date: 01/03/1995
• Status: Expired due to Fees

• Current Assignee: Michael Anbar
• Original Assignee: Michael Anbar
• Inventors: Anbar, Michael
• Primary Examiner(s): Casler, Brian L.
• Application Number:
  US08/368,161
• Time in Patent Office: 1,358 Days
• Field of Search: 128/661.08, 128/691, 128/737, 128/736, 128/653.1, 128/664, 128/665, 128/742, 128/65.3, 128/637, 128/632, 128/633, 128/653.2
• US Class Current: 600/474
• CPC Class Codes: A61B 2010/008 Interstitial fluid
• CPC Class Codes: A61B 5/015 By temperature mapping of body part
• CPC Class Codes: A61B 5/7257 using Fourier transforms
• CPC Class Codes: G01N 33/574 for cancer
• CPC Class Codes: G01N 33/57415 of breast
• CPC Class Codes: G06T 7/0012 Biomedical image inspection

Abstract

The present invention comprises methods and apparatus for cancer detection involving the measurement of temporal periodic changes in blood perfusion associated with immune response, occurring in neoplastic lesions and their surrounding tissues. Particularly, the method for cancer detection involves the detection of non-neuronal thermoregulation of blood perfusion, aberrant modulation of blood perfusion, aberrant temperature oscillations associated with blood perfusion, aberrant thermoregulatory frequencies associated with blood perfusion, and periodic changes in the spatial homogeneity of skin temperature.

Claims

1. A method for detecting cancerous tissue in humans comprising the steps of:

a) providing a detecting means for detecting changes in a characteristic modulation of blood perfusion in a human organ;

b) detecting, with said detecting means, said changes in the characteristic modulation of blood perfusion in a human organ; and

c) identifying as cancerous a region of said human organ wherein said changes in the characteristic modulation of blood perfusion are detected.

2. A method according to claim 1 wherein said detecting means is DAT.

3. A method according to claim 1 wherein said detecting means is an infrared sensing system.

4. A method according to claim 1 wherein said detecting means is MRI.

5. A method according to claim 1 wherein said detecting means is an ultrasound imaging system.

6. A method according to claim 1 wherein said changes in modulation of blood perfusion are manifested by a loss of said modulation of blood perfusion.

7. A method according to claim 1 wherein said detecting means is a Laser Doppler System.

8. A method according to claim 1 wherein said detecting means is a paramagnetic resonance system.

9. A method according to claim 1 wherein said changes in modulation of blood perfusion are detected by the steps of:

a) providing a means for detecting aberrations in temperature oscillations associated with blood perfusion in a plurality of parts of a human organ;

b) detecting, with said detecting means, said aberrations in said temperature oscillations in said plurality of parts of a human organ.

10. A method according to claim 1 wherein said changes in modulation of blood perfusion are detected by the steps of:

a) providing a means for measuring NO concentration in a plurality of parts of a human organ;

b) providing a means for comparing relative concentrations of NO in said plurality of parts of a human organ;

c) measuring concentration of NO, with said measuring means, in said plurality of parts of a human organ;

d) comparing said concentrations of NO in each of said plurality of parts of a human organ;

e) providing a detecting means for detecting periodic oscillations in the concentration of NO in said plurality of parts of a human organ;

f) detecting, with said detecting means, said periodic oscillations in the concentration of NO in said plurality of parts of a human organ.

11. A method according to claim 1 wherein said organ is a breast.

12. A method according to claim 11 comprising the additional preliminary steps of:

a) providing a means for cooling said breast;

b) cooling said breast to accentuate a variance between a cancerous and noncancerous area of said breast.

13. A method according to claim 1 wherein said organ is skin.

14. A method according to claim 13 comprising the additional preliminary steps of:

a) providing a means for cooling said skin;

b) cooling said skin to accentuate a variance between a cancerous and noncancerous area of said skin.